9OMY

Cryo-EM structure of an octameric RAD51-XRCC3-RAD51C (RAD51-X3C) complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000150	molecular_function	DNA strand exchange activity
A	0000152	cellular_component	nuclear ubiquitin ligase complex
A	0000228	cellular_component	nuclear chromosome
A	0000722	biological_process	telomere maintenance via recombination
A	0000724	biological_process	double-strand break repair via homologous recombination
A	0000730	biological_process	DNA recombinase assembly
A	0000781	cellular_component	chromosome, telomeric region
A	0000785	cellular_component	chromatin
A	0000793	cellular_component	condensed chromosome
A	0000794	cellular_component	condensed nuclear chromosome
A	0000800	cellular_component	lateral element
A	0003682	molecular_function	chromatin binding
A	0003690	molecular_function	double-stranded DNA binding
A	0003697	molecular_function	single-stranded DNA binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005813	cellular_component	centrosome
A	0005829	cellular_component	cytosol
A	0006281	biological_process	DNA repair
A	0006310	biological_process	DNA recombination
A	0006312	biological_process	mitotic recombination
A	0006974	biological_process	DNA damage response
A	0007127	biological_process	meiosis I
A	0007131	biological_process	reciprocal meiotic recombination
A	0008094	molecular_function	ATP-dependent activity, acting on DNA
A	0009410	biological_process	response to xenobiotic stimulus
A	0009636	biological_process	response to toxic substance
A	0010165	biological_process	response to X-ray
A	0010569	biological_process	regulation of double-strand break repair via homologous recombination
A	0010833	biological_process	telomere maintenance via telomere lengthening
A	0016605	cellular_component	PML body
A	0016887	molecular_function	ATP hydrolysis activity
A	0019899	molecular_function	enzyme binding
A	0031297	biological_process	replication fork processing
A	0031491	molecular_function	nucleosome binding
A	0032991	cellular_component	protein-containing complex
A	0032993	cellular_component	protein-DNA complex
A	0035861	cellular_component	site of double-strand break
A	0036297	biological_process	interstrand cross-link repair
A	0042148	biological_process	DNA strand invasion
A	0042802	molecular_function	identical protein binding
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0051321	biological_process	meiotic cell cycle
A	0070182	molecular_function	DNA polymerase binding
A	0070192	biological_process	chromosome organization involved in meiotic cell cycle
A	0071479	biological_process	cellular response to ionizing radiation
A	0071480	biological_process	cellular response to gamma radiation
A	0072719	biological_process	cellular response to cisplatin
A	0072757	biological_process	cellular response to camptothecin
A	0099182	cellular_component	presynaptic intermediate filament cytoskeleton
A	1904631	biological_process	response to glucoside
A	1990918	biological_process	double-strand break repair involved in meiotic recombination
A	2000001	biological_process	regulation of DNA damage checkpoint
B	0000150	molecular_function	DNA strand exchange activity
B	0000152	cellular_component	nuclear ubiquitin ligase complex
B	0000228	cellular_component	nuclear chromosome
B	0000722	biological_process	telomere maintenance via recombination
B	0000724	biological_process	double-strand break repair via homologous recombination
B	0000730	biological_process	DNA recombinase assembly
B	0000781	cellular_component	chromosome, telomeric region
B	0000785	cellular_component	chromatin
B	0000793	cellular_component	condensed chromosome
B	0000794	cellular_component	condensed nuclear chromosome
B	0000800	cellular_component	lateral element
B	0003682	molecular_function	chromatin binding
B	0003690	molecular_function	double-stranded DNA binding
B	0003697	molecular_function	single-stranded DNA binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005694	cellular_component	chromosome
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0005813	cellular_component	centrosome
B	0005829	cellular_component	cytosol
B	0006281	biological_process	DNA repair
B	0006310	biological_process	DNA recombination
B	0006312	biological_process	mitotic recombination
B	0006974	biological_process	DNA damage response
B	0007127	biological_process	meiosis I
B	0007131	biological_process	reciprocal meiotic recombination
B	0008094	molecular_function	ATP-dependent activity, acting on DNA
B	0009410	biological_process	response to xenobiotic stimulus
B	0009636	biological_process	response to toxic substance
B	0010165	biological_process	response to X-ray
B	0010569	biological_process	regulation of double-strand break repair via homologous recombination
B	0010833	biological_process	telomere maintenance via telomere lengthening
B	0016605	cellular_component	PML body
B	0016887	molecular_function	ATP hydrolysis activity
B	0019899	molecular_function	enzyme binding
B	0031297	biological_process	replication fork processing
B	0031491	molecular_function	nucleosome binding
B	0032991	cellular_component	protein-containing complex
B	0032993	cellular_component	protein-DNA complex
B	0035861	cellular_component	site of double-strand break
B	0036297	biological_process	interstrand cross-link repair
B	0042148	biological_process	DNA strand invasion
B	0042802	molecular_function	identical protein binding
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0051321	biological_process	meiotic cell cycle
B	0070182	molecular_function	DNA polymerase binding
B	0070192	biological_process	chromosome organization involved in meiotic cell cycle
B	0071479	biological_process	cellular response to ionizing radiation
B	0071480	biological_process	cellular response to gamma radiation
B	0072719	biological_process	cellular response to cisplatin
B	0072757	biological_process	cellular response to camptothecin
B	0099182	cellular_component	presynaptic intermediate filament cytoskeleton
B	1904631	biological_process	response to glucoside
B	1990918	biological_process	double-strand break repair involved in meiotic recombination
B	2000001	biological_process	regulation of DNA damage checkpoint
C	0000400	molecular_function	four-way junction DNA binding
C	0000707	biological_process	meiotic DNA recombinase assembly
C	0000722	biological_process	telomere maintenance via recombination
C	0000724	biological_process	double-strand break repair via homologous recombination
C	0003677	molecular_function	DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005657	cellular_component	replication fork
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0006281	biological_process	DNA repair
C	0006310	biological_process	DNA recombination
C	0007062	biological_process	sister chromatid cohesion
C	0008821	molecular_function	crossover junction DNA endonuclease activity
C	0010971	biological_process	positive regulation of G2/M transition of mitotic cell cycle
C	0031297	biological_process	replication fork processing
C	0033063	cellular_component	Rad51B-Rad51C-Rad51D-XRCC2 complex
C	0033065	cellular_component	Rad51C-XRCC3 complex
C	0043596	cellular_component	nuclear replication fork
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0097435	biological_process	supramolecular fiber organization
D	0000150	molecular_function	DNA strand exchange activity
D	0000152	cellular_component	nuclear ubiquitin ligase complex
D	0000228	cellular_component	nuclear chromosome
D	0000722	biological_process	telomere maintenance via recombination
D	0000724	biological_process	double-strand break repair via homologous recombination
D	0000730	biological_process	DNA recombinase assembly
D	0000781	cellular_component	chromosome, telomeric region
D	0000785	cellular_component	chromatin
D	0000793	cellular_component	condensed chromosome
D	0000794	cellular_component	condensed nuclear chromosome
D	0000800	cellular_component	lateral element
D	0003682	molecular_function	chromatin binding
D	0003690	molecular_function	double-stranded DNA binding
D	0003697	molecular_function	single-stranded DNA binding
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005694	cellular_component	chromosome
D	0005730	cellular_component	nucleolus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0005813	cellular_component	centrosome
D	0005829	cellular_component	cytosol
D	0006281	biological_process	DNA repair
D	0006310	biological_process	DNA recombination
D	0006312	biological_process	mitotic recombination
D	0006974	biological_process	DNA damage response
D	0007127	biological_process	meiosis I
D	0007131	biological_process	reciprocal meiotic recombination
D	0008094	molecular_function	ATP-dependent activity, acting on DNA
D	0009410	biological_process	response to xenobiotic stimulus
D	0009636	biological_process	response to toxic substance
D	0010165	biological_process	response to X-ray
D	0010569	biological_process	regulation of double-strand break repair via homologous recombination
D	0010833	biological_process	telomere maintenance via telomere lengthening
D	0016605	cellular_component	PML body
D	0016887	molecular_function	ATP hydrolysis activity
D	0019899	molecular_function	enzyme binding
D	0031297	biological_process	replication fork processing
D	0031491	molecular_function	nucleosome binding
D	0032991	cellular_component	protein-containing complex
D	0032993	cellular_component	protein-DNA complex
D	0035861	cellular_component	site of double-strand break
D	0036297	biological_process	interstrand cross-link repair
D	0042148	biological_process	DNA strand invasion
D	0042802	molecular_function	identical protein binding
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0051321	biological_process	meiotic cell cycle
D	0070182	molecular_function	DNA polymerase binding
D	0070192	biological_process	chromosome organization involved in meiotic cell cycle
D	0071479	biological_process	cellular response to ionizing radiation
D	0071480	biological_process	cellular response to gamma radiation
D	0072719	biological_process	cellular response to cisplatin
D	0072757	biological_process	cellular response to camptothecin
D	0099182	cellular_component	presynaptic intermediate filament cytoskeleton
D	1904631	biological_process	response to glucoside
D	1990918	biological_process	double-strand break repair involved in meiotic recombination
D	2000001	biological_process	regulation of DNA damage checkpoint
E	0000150	molecular_function	DNA strand exchange activity
E	0000152	cellular_component	nuclear ubiquitin ligase complex
E	0000228	cellular_component	nuclear chromosome
E	0000722	biological_process	telomere maintenance via recombination
E	0000724	biological_process	double-strand break repair via homologous recombination
E	0000730	biological_process	DNA recombinase assembly
E	0000781	cellular_component	chromosome, telomeric region
E	0000785	cellular_component	chromatin
E	0000793	cellular_component	condensed chromosome
E	0000794	cellular_component	condensed nuclear chromosome
E	0000800	cellular_component	lateral element
E	0003682	molecular_function	chromatin binding
E	0003690	molecular_function	double-stranded DNA binding
E	0003697	molecular_function	single-stranded DNA binding
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005694	cellular_component	chromosome
E	0005730	cellular_component	nucleolus
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005759	cellular_component	mitochondrial matrix
E	0005813	cellular_component	centrosome
E	0005829	cellular_component	cytosol
E	0006281	biological_process	DNA repair
E	0006310	biological_process	DNA recombination
E	0006312	biological_process	mitotic recombination
E	0006974	biological_process	DNA damage response
E	0007127	biological_process	meiosis I
E	0007131	biological_process	reciprocal meiotic recombination
E	0008094	molecular_function	ATP-dependent activity, acting on DNA
E	0009410	biological_process	response to xenobiotic stimulus
E	0009636	biological_process	response to toxic substance
E	0010165	biological_process	response to X-ray
E	0010569	biological_process	regulation of double-strand break repair via homologous recombination
E	0010833	biological_process	telomere maintenance via telomere lengthening
E	0016605	cellular_component	PML body
E	0016887	molecular_function	ATP hydrolysis activity
E	0019899	molecular_function	enzyme binding
E	0031297	biological_process	replication fork processing
E	0031491	molecular_function	nucleosome binding
E	0032991	cellular_component	protein-containing complex
E	0032993	cellular_component	protein-DNA complex
E	0035861	cellular_component	site of double-strand break
E	0036297	biological_process	interstrand cross-link repair
E	0042148	biological_process	DNA strand invasion
E	0042802	molecular_function	identical protein binding
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0051321	biological_process	meiotic cell cycle
E	0070182	molecular_function	DNA polymerase binding
E	0070192	biological_process	chromosome organization involved in meiotic cell cycle
E	0071479	biological_process	cellular response to ionizing radiation
E	0071480	biological_process	cellular response to gamma radiation
E	0072719	biological_process	cellular response to cisplatin
E	0072757	biological_process	cellular response to camptothecin
E	0099182	cellular_component	presynaptic intermediate filament cytoskeleton
E	1904631	biological_process	response to glucoside
E	1990918	biological_process	double-strand break repair involved in meiotic recombination
E	2000001	biological_process	regulation of DNA damage checkpoint
F	0000400	molecular_function	four-way junction DNA binding
F	0000707	biological_process	meiotic DNA recombinase assembly
F	0000722	biological_process	telomere maintenance via recombination
F	0000724	biological_process	double-strand break repair via homologous recombination
F	0003677	molecular_function	DNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005657	cellular_component	replication fork
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005829	cellular_component	cytosol
F	0006281	biological_process	DNA repair
F	0006310	biological_process	DNA recombination
F	0007062	biological_process	sister chromatid cohesion
F	0008821	molecular_function	crossover junction DNA endonuclease activity
F	0010971	biological_process	positive regulation of G2/M transition of mitotic cell cycle
F	0031297	biological_process	replication fork processing
F	0033063	cellular_component	Rad51B-Rad51C-Rad51D-XRCC2 complex
F	0033065	cellular_component	Rad51C-XRCC3 complex
F	0043596	cellular_component	nuclear replication fork
F	0048471	cellular_component	perinuclear region of cytoplasm
F	0097435	biological_process	supramolecular fiber organization
G	0000400	molecular_function	four-way junction DNA binding
G	0000722	biological_process	telomere maintenance via recombination
G	0000724	biological_process	double-strand break repair via homologous recombination
G	0000781	cellular_component	chromosome, telomeric region
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005657	cellular_component	replication fork
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0006281	biological_process	DNA repair
G	0006310	biological_process	DNA recombination
G	0006974	biological_process	DNA damage response
G	0008821	molecular_function	crossover junction DNA endonuclease activity
G	0010824	biological_process	regulation of centrosome duplication
G	0031297	biological_process	replication fork processing
G	0033065	cellular_component	Rad51C-XRCC3 complex
G	0036297	biological_process	interstrand cross-link repair
G	0043596	cellular_component	nuclear replication fork
G	0048471	cellular_component	perinuclear region of cytoplasm
G	0071140	biological_process	resolution of mitotic recombination intermediates
G	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
G	0090656	biological_process	t-circle formation
G	0090657	biological_process	telomeric loop disassembly
G	0090737	biological_process	telomere maintenance via telomere trimming
X	0000400	molecular_function	four-way junction DNA binding
X	0000722	biological_process	telomere maintenance via recombination
X	0000724	biological_process	double-strand break repair via homologous recombination
X	0000781	cellular_component	chromosome, telomeric region
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005657	cellular_component	replication fork
X	0005737	cellular_component	cytoplasm
X	0005739	cellular_component	mitochondrion
X	0006281	biological_process	DNA repair
X	0006310	biological_process	DNA recombination
X	0006974	biological_process	DNA damage response
X	0008821	molecular_function	crossover junction DNA endonuclease activity
X	0010824	biological_process	regulation of centrosome duplication
X	0031297	biological_process	replication fork processing
X	0033065	cellular_component	Rad51C-XRCC3 complex
X	0036297	biological_process	interstrand cross-link repair
X	0043596	cellular_component	nuclear replication fork
X	0048471	cellular_component	perinuclear region of cytoplasm
X	0071140	biological_process	resolution of mitotic recombination intermediates
X	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
X	0090656	biological_process	t-circle formation
X	0090657	biological_process	telomeric loop disassembly
X	0090737	biological_process	telomere maintenance via telomere trimming

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	116
Details	Domain: {"description":"HhH"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	292
Details	Region: {"description":"Interaction with PALB2"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	60
Details	Motif: {"description":"Nuclear export signal; masked by the interaction with BRCA2","evidences":[{"source":"PubMed","id":"24013206","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	40
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29507080","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5NWL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine; by ABL1","evidences":[{"source":"PubMed","id":"9461559","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine; by CHEK1","evidences":[{"source":"PubMed","id":"15665856","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	12
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23393192","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI8
Number of Residues	28
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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