9OH9

Human Stomatin Complex in Native Membrane Vesicles

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005783	cellular_component	endoplasmic reticulum
A	0005856	cellular_component	cytoskeleton
A	0005886	cellular_component	plasma membrane
A	0008200	molecular_function	ion channel inhibitor activity
A	0016020	cellular_component	membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0031982	cellular_component	vesicle
A	0034765	biological_process	regulation of monoatomic ion transmembrane transport
A	0035577	cellular_component	azurophil granule membrane
A	0035579	cellular_component	specific granule membrane
A	0042470	cellular_component	melanosome
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0044829	biological_process	host-mediated activation of viral genome replication
A	0045121	cellular_component	membrane raft
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0048524	biological_process	positive regulation of viral process
A	0070062	cellular_component	extracellular exosome
A	0070063	molecular_function	RNA polymerase binding
A	0070821	cellular_component	tertiary granule membrane
A	0072562	cellular_component	blood microparticle
A	0090314	biological_process	positive regulation of protein targeting to membrane
B	0005515	molecular_function	protein binding
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005783	cellular_component	endoplasmic reticulum
B	0005856	cellular_component	cytoskeleton
B	0005886	cellular_component	plasma membrane
B	0008200	molecular_function	ion channel inhibitor activity
B	0016020	cellular_component	membrane
B	0031410	cellular_component	cytoplasmic vesicle
B	0031982	cellular_component	vesicle
B	0034765	biological_process	regulation of monoatomic ion transmembrane transport
B	0035577	cellular_component	azurophil granule membrane
B	0035579	cellular_component	specific granule membrane
B	0042470	cellular_component	melanosome
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0044829	biological_process	host-mediated activation of viral genome replication
B	0045121	cellular_component	membrane raft
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0048524	biological_process	positive regulation of viral process
B	0070062	cellular_component	extracellular exosome
B	0070063	molecular_function	RNA polymerase binding
B	0070821	cellular_component	tertiary granule membrane
B	0072562	cellular_component	blood microparticle
B	0090314	biological_process	positive regulation of protein targeting to membrane
C	0005515	molecular_function	protein binding
C	0005615	cellular_component	extracellular space
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005783	cellular_component	endoplasmic reticulum
C	0005856	cellular_component	cytoskeleton
C	0005886	cellular_component	plasma membrane
C	0008200	molecular_function	ion channel inhibitor activity
C	0016020	cellular_component	membrane
C	0031410	cellular_component	cytoplasmic vesicle
C	0031982	cellular_component	vesicle
C	0034765	biological_process	regulation of monoatomic ion transmembrane transport
C	0035577	cellular_component	azurophil granule membrane
C	0035579	cellular_component	specific granule membrane
C	0042470	cellular_component	melanosome
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0044829	biological_process	host-mediated activation of viral genome replication
C	0045121	cellular_component	membrane raft
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0048524	biological_process	positive regulation of viral process
C	0070062	cellular_component	extracellular exosome
C	0070063	molecular_function	RNA polymerase binding
C	0070821	cellular_component	tertiary granule membrane
C	0072562	cellular_component	blood microparticle
C	0090314	biological_process	positive regulation of protein targeting to membrane
D	0005515	molecular_function	protein binding
D	0005615	cellular_component	extracellular space
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005783	cellular_component	endoplasmic reticulum
D	0005856	cellular_component	cytoskeleton
D	0005886	cellular_component	plasma membrane
D	0008200	molecular_function	ion channel inhibitor activity
D	0016020	cellular_component	membrane
D	0031410	cellular_component	cytoplasmic vesicle
D	0031982	cellular_component	vesicle
D	0034765	biological_process	regulation of monoatomic ion transmembrane transport
D	0035577	cellular_component	azurophil granule membrane
D	0035579	cellular_component	specific granule membrane
D	0042470	cellular_component	melanosome
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0044829	biological_process	host-mediated activation of viral genome replication
D	0045121	cellular_component	membrane raft
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0048524	biological_process	positive regulation of viral process
D	0070062	cellular_component	extracellular exosome
D	0070063	molecular_function	RNA polymerase binding
D	0070821	cellular_component	tertiary granule membrane
D	0072562	cellular_component	blood microparticle
D	0090314	biological_process	positive regulation of protein targeting to membrane
E	0005515	molecular_function	protein binding
E	0005615	cellular_component	extracellular space
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005783	cellular_component	endoplasmic reticulum
E	0005856	cellular_component	cytoskeleton
E	0005886	cellular_component	plasma membrane
E	0008200	molecular_function	ion channel inhibitor activity
E	0016020	cellular_component	membrane
E	0031410	cellular_component	cytoplasmic vesicle
E	0031982	cellular_component	vesicle
E	0034765	biological_process	regulation of monoatomic ion transmembrane transport
E	0035577	cellular_component	azurophil granule membrane
E	0035579	cellular_component	specific granule membrane
E	0042470	cellular_component	melanosome
E	0042802	molecular_function	identical protein binding
E	0042803	molecular_function	protein homodimerization activity
E	0044829	biological_process	host-mediated activation of viral genome replication
E	0045121	cellular_component	membrane raft
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0048524	biological_process	positive regulation of viral process
E	0070062	cellular_component	extracellular exosome
E	0070063	molecular_function	RNA polymerase binding
E	0070821	cellular_component	tertiary granule membrane
E	0072562	cellular_component	blood microparticle
E	0090314	biological_process	positive regulation of protein targeting to membrane
F	0005515	molecular_function	protein binding
F	0005615	cellular_component	extracellular space
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005783	cellular_component	endoplasmic reticulum
F	0005856	cellular_component	cytoskeleton
F	0005886	cellular_component	plasma membrane
F	0008200	molecular_function	ion channel inhibitor activity
F	0016020	cellular_component	membrane
F	0031410	cellular_component	cytoplasmic vesicle
F	0031982	cellular_component	vesicle
F	0034765	biological_process	regulation of monoatomic ion transmembrane transport
F	0035577	cellular_component	azurophil granule membrane
F	0035579	cellular_component	specific granule membrane
F	0042470	cellular_component	melanosome
F	0042802	molecular_function	identical protein binding
F	0042803	molecular_function	protein homodimerization activity
F	0044829	biological_process	host-mediated activation of viral genome replication
F	0045121	cellular_component	membrane raft
F	0048471	cellular_component	perinuclear region of cytoplasm
F	0048524	biological_process	positive regulation of viral process
F	0070062	cellular_component	extracellular exosome
F	0070063	molecular_function	RNA polymerase binding
F	0070821	cellular_component	tertiary granule membrane
F	0072562	cellular_component	blood microparticle
F	0090314	biological_process	positive regulation of protein targeting to membrane
G	0005515	molecular_function	protein binding
G	0005615	cellular_component	extracellular space
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005783	cellular_component	endoplasmic reticulum
G	0005856	cellular_component	cytoskeleton
G	0005886	cellular_component	plasma membrane
G	0008200	molecular_function	ion channel inhibitor activity
G	0016020	cellular_component	membrane
G	0031410	cellular_component	cytoplasmic vesicle
G	0031982	cellular_component	vesicle
G	0034765	biological_process	regulation of monoatomic ion transmembrane transport
G	0035577	cellular_component	azurophil granule membrane
G	0035579	cellular_component	specific granule membrane
G	0042470	cellular_component	melanosome
G	0042802	molecular_function	identical protein binding
G	0042803	molecular_function	protein homodimerization activity
G	0044829	biological_process	host-mediated activation of viral genome replication
G	0045121	cellular_component	membrane raft
G	0048471	cellular_component	perinuclear region of cytoplasm
G	0048524	biological_process	positive regulation of viral process
G	0070062	cellular_component	extracellular exosome
G	0070063	molecular_function	RNA polymerase binding
G	0070821	cellular_component	tertiary granule membrane
G	0072562	cellular_component	blood microparticle
G	0090314	biological_process	positive regulation of protein targeting to membrane
H	0005515	molecular_function	protein binding
H	0005615	cellular_component	extracellular space
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005783	cellular_component	endoplasmic reticulum
H	0005856	cellular_component	cytoskeleton
H	0005886	cellular_component	plasma membrane
H	0008200	molecular_function	ion channel inhibitor activity
H	0016020	cellular_component	membrane
H	0031410	cellular_component	cytoplasmic vesicle
H	0031982	cellular_component	vesicle
H	0034765	biological_process	regulation of monoatomic ion transmembrane transport
H	0035577	cellular_component	azurophil granule membrane
H	0035579	cellular_component	specific granule membrane
H	0042470	cellular_component	melanosome
H	0042802	molecular_function	identical protein binding
H	0042803	molecular_function	protein homodimerization activity
H	0044829	biological_process	host-mediated activation of viral genome replication
H	0045121	cellular_component	membrane raft
H	0048471	cellular_component	perinuclear region of cytoplasm
H	0048524	biological_process	positive regulation of viral process
H	0070062	cellular_component	extracellular exosome
H	0070063	molecular_function	RNA polymerase binding
H	0070821	cellular_component	tertiary granule membrane
H	0072562	cellular_component	blood microparticle
H	0090314	biological_process	positive regulation of protein targeting to membrane
I	0005515	molecular_function	protein binding
I	0005615	cellular_component	extracellular space
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005783	cellular_component	endoplasmic reticulum
I	0005856	cellular_component	cytoskeleton
I	0005886	cellular_component	plasma membrane
I	0008200	molecular_function	ion channel inhibitor activity
I	0016020	cellular_component	membrane
I	0031410	cellular_component	cytoplasmic vesicle
I	0031982	cellular_component	vesicle
I	0034765	biological_process	regulation of monoatomic ion transmembrane transport
I	0035577	cellular_component	azurophil granule membrane
I	0035579	cellular_component	specific granule membrane
I	0042470	cellular_component	melanosome
I	0042802	molecular_function	identical protein binding
I	0042803	molecular_function	protein homodimerization activity
I	0044829	biological_process	host-mediated activation of viral genome replication
I	0045121	cellular_component	membrane raft
I	0048471	cellular_component	perinuclear region of cytoplasm
I	0048524	biological_process	positive regulation of viral process
I	0070062	cellular_component	extracellular exosome
I	0070063	molecular_function	RNA polymerase binding
I	0070821	cellular_component	tertiary granule membrane
I	0072562	cellular_component	blood microparticle
I	0090314	biological_process	positive regulation of protein targeting to membrane
J	0005515	molecular_function	protein binding
J	0005615	cellular_component	extracellular space
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0005783	cellular_component	endoplasmic reticulum
J	0005856	cellular_component	cytoskeleton
J	0005886	cellular_component	plasma membrane
J	0008200	molecular_function	ion channel inhibitor activity
J	0016020	cellular_component	membrane
J	0031410	cellular_component	cytoplasmic vesicle
J	0031982	cellular_component	vesicle
J	0034765	biological_process	regulation of monoatomic ion transmembrane transport
J	0035577	cellular_component	azurophil granule membrane
J	0035579	cellular_component	specific granule membrane
J	0042470	cellular_component	melanosome
J	0042802	molecular_function	identical protein binding
J	0042803	molecular_function	protein homodimerization activity
J	0044829	biological_process	host-mediated activation of viral genome replication
J	0045121	cellular_component	membrane raft
J	0048471	cellular_component	perinuclear region of cytoplasm
J	0048524	biological_process	positive regulation of viral process
J	0070062	cellular_component	extracellular exosome
J	0070063	molecular_function	RNA polymerase binding
J	0070821	cellular_component	tertiary granule membrane
J	0072562	cellular_component	blood microparticle
J	0090314	biological_process	positive regulation of protein targeting to membrane
K	0005515	molecular_function	protein binding
K	0005615	cellular_component	extracellular space
K	0005737	cellular_component	cytoplasm
K	0005739	cellular_component	mitochondrion
K	0005783	cellular_component	endoplasmic reticulum
K	0005856	cellular_component	cytoskeleton
K	0005886	cellular_component	plasma membrane
K	0008200	molecular_function	ion channel inhibitor activity
K	0016020	cellular_component	membrane
K	0031410	cellular_component	cytoplasmic vesicle
K	0031982	cellular_component	vesicle
K	0034765	biological_process	regulation of monoatomic ion transmembrane transport
K	0035577	cellular_component	azurophil granule membrane
K	0035579	cellular_component	specific granule membrane
K	0042470	cellular_component	melanosome
K	0042802	molecular_function	identical protein binding
K	0042803	molecular_function	protein homodimerization activity
K	0044829	biological_process	host-mediated activation of viral genome replication
K	0045121	cellular_component	membrane raft
K	0048471	cellular_component	perinuclear region of cytoplasm
K	0048524	biological_process	positive regulation of viral process
K	0070062	cellular_component	extracellular exosome
K	0070063	molecular_function	RNA polymerase binding
K	0070821	cellular_component	tertiary granule membrane
K	0072562	cellular_component	blood microparticle
K	0090314	biological_process	positive regulation of protein targeting to membrane
L	0005515	molecular_function	protein binding
L	0005615	cellular_component	extracellular space
L	0005737	cellular_component	cytoplasm
L	0005739	cellular_component	mitochondrion
L	0005783	cellular_component	endoplasmic reticulum
L	0005856	cellular_component	cytoskeleton
L	0005886	cellular_component	plasma membrane
L	0008200	molecular_function	ion channel inhibitor activity
L	0016020	cellular_component	membrane
L	0031410	cellular_component	cytoplasmic vesicle
L	0031982	cellular_component	vesicle
L	0034765	biological_process	regulation of monoatomic ion transmembrane transport
L	0035577	cellular_component	azurophil granule membrane
L	0035579	cellular_component	specific granule membrane
L	0042470	cellular_component	melanosome
L	0042802	molecular_function	identical protein binding
L	0042803	molecular_function	protein homodimerization activity
L	0044829	biological_process	host-mediated activation of viral genome replication
L	0045121	cellular_component	membrane raft
L	0048471	cellular_component	perinuclear region of cytoplasm
L	0048524	biological_process	positive regulation of viral process
L	0070062	cellular_component	extracellular exosome
L	0070063	molecular_function	RNA polymerase binding
L	0070821	cellular_component	tertiary granule membrane
L	0072562	cellular_component	blood microparticle
L	0090314	biological_process	positive regulation of protein targeting to membrane
M	0005515	molecular_function	protein binding
M	0005615	cellular_component	extracellular space
M	0005737	cellular_component	cytoplasm
M	0005739	cellular_component	mitochondrion
M	0005783	cellular_component	endoplasmic reticulum
M	0005856	cellular_component	cytoskeleton
M	0005886	cellular_component	plasma membrane
M	0008200	molecular_function	ion channel inhibitor activity
M	0016020	cellular_component	membrane
M	0031410	cellular_component	cytoplasmic vesicle
M	0031982	cellular_component	vesicle
M	0034765	biological_process	regulation of monoatomic ion transmembrane transport
M	0035577	cellular_component	azurophil granule membrane
M	0035579	cellular_component	specific granule membrane
M	0042470	cellular_component	melanosome
M	0042802	molecular_function	identical protein binding
M	0042803	molecular_function	protein homodimerization activity
M	0044829	biological_process	host-mediated activation of viral genome replication
M	0045121	cellular_component	membrane raft
M	0048471	cellular_component	perinuclear region of cytoplasm
M	0048524	biological_process	positive regulation of viral process
M	0070062	cellular_component	extracellular exosome
M	0070063	molecular_function	RNA polymerase binding
M	0070821	cellular_component	tertiary granule membrane
M	0072562	cellular_component	blood microparticle
M	0090314	biological_process	positive regulation of protein targeting to membrane
N	0005515	molecular_function	protein binding
N	0005615	cellular_component	extracellular space
N	0005737	cellular_component	cytoplasm
N	0005739	cellular_component	mitochondrion
N	0005783	cellular_component	endoplasmic reticulum
N	0005856	cellular_component	cytoskeleton
N	0005886	cellular_component	plasma membrane
N	0008200	molecular_function	ion channel inhibitor activity
N	0016020	cellular_component	membrane
N	0031410	cellular_component	cytoplasmic vesicle
N	0031982	cellular_component	vesicle
N	0034765	biological_process	regulation of monoatomic ion transmembrane transport
N	0035577	cellular_component	azurophil granule membrane
N	0035579	cellular_component	specific granule membrane
N	0042470	cellular_component	melanosome
N	0042802	molecular_function	identical protein binding
N	0042803	molecular_function	protein homodimerization activity
N	0044829	biological_process	host-mediated activation of viral genome replication
N	0045121	cellular_component	membrane raft
N	0048471	cellular_component	perinuclear region of cytoplasm
N	0048524	biological_process	positive regulation of viral process
N	0070062	cellular_component	extracellular exosome
N	0070063	molecular_function	RNA polymerase binding
N	0070821	cellular_component	tertiary granule membrane
N	0072562	cellular_component	blood microparticle
N	0090314	biological_process	positive regulation of protein targeting to membrane
O	0005515	molecular_function	protein binding
O	0005615	cellular_component	extracellular space
O	0005737	cellular_component	cytoplasm
O	0005739	cellular_component	mitochondrion
O	0005783	cellular_component	endoplasmic reticulum
O	0005856	cellular_component	cytoskeleton
O	0005886	cellular_component	plasma membrane
O	0008200	molecular_function	ion channel inhibitor activity
O	0016020	cellular_component	membrane
O	0031410	cellular_component	cytoplasmic vesicle
O	0031982	cellular_component	vesicle
O	0034765	biological_process	regulation of monoatomic ion transmembrane transport
O	0035577	cellular_component	azurophil granule membrane
O	0035579	cellular_component	specific granule membrane
O	0042470	cellular_component	melanosome
O	0042802	molecular_function	identical protein binding
O	0042803	molecular_function	protein homodimerization activity
O	0044829	biological_process	host-mediated activation of viral genome replication
O	0045121	cellular_component	membrane raft
O	0048471	cellular_component	perinuclear region of cytoplasm
O	0048524	biological_process	positive regulation of viral process
O	0070062	cellular_component	extracellular exosome
O	0070063	molecular_function	RNA polymerase binding
O	0070821	cellular_component	tertiary granule membrane
O	0072562	cellular_component	blood microparticle
O	0090314	biological_process	positive regulation of protein targeting to membrane
P	0005515	molecular_function	protein binding
P	0005615	cellular_component	extracellular space
P	0005737	cellular_component	cytoplasm
P	0005739	cellular_component	mitochondrion
P	0005783	cellular_component	endoplasmic reticulum
P	0005856	cellular_component	cytoskeleton
P	0005886	cellular_component	plasma membrane
P	0008200	molecular_function	ion channel inhibitor activity
P	0016020	cellular_component	membrane
P	0031410	cellular_component	cytoplasmic vesicle
P	0031982	cellular_component	vesicle
P	0034765	biological_process	regulation of monoatomic ion transmembrane transport
P	0035577	cellular_component	azurophil granule membrane
P	0035579	cellular_component	specific granule membrane
P	0042470	cellular_component	melanosome
P	0042802	molecular_function	identical protein binding
P	0042803	molecular_function	protein homodimerization activity
P	0044829	biological_process	host-mediated activation of viral genome replication
P	0045121	cellular_component	membrane raft
P	0048471	cellular_component	perinuclear region of cytoplasm
P	0048524	biological_process	positive regulation of viral process
P	0070062	cellular_component	extracellular exosome
P	0070063	molecular_function	RNA polymerase binding
P	0070821	cellular_component	tertiary granule membrane
P	0072562	cellular_component	blood microparticle
P	0090314	biological_process	positive regulation of protein targeting to membrane

Functional Information from PROSITE/UniProt

site_id	PS01270
Number of Residues	29
Details	BAND_7 Band 7 protein family signature. ReeIAhnmqstLDdaTdaWGIKVeRVEIK

Chain	Residue	Details
A	ARG167-LYS195

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	128
Details	Region: {"description":"Required for homooligomerization"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	32
Details	Region: {"description":"Required for lipid raft association"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P54116","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	16
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	16
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"10338112","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	16
Details	Lipidation: {"description":"S-palmitoyl cysteine; partial","evidences":[{"source":"PubMed","id":"10338112","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---