9O9U

The Erlin1/2 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0005515	molecular_function	protein binding
a	0005783	cellular_component	endoplasmic reticulum
a	0005789	cellular_component	endoplasmic reticulum membrane
a	0005886	cellular_component	plasma membrane
a	0006629	biological_process	lipid metabolic process
a	0008202	biological_process	steroid metabolic process
a	0008203	biological_process	cholesterol metabolic process
a	0015485	molecular_function	cholesterol binding
a	0031625	molecular_function	ubiquitin protein ligase binding
a	0032933	biological_process	SREBP signaling pathway
a	0032991	cellular_component	protein-containing complex
a	0036503	biological_process	ERAD pathway
a	0045121	cellular_component	membrane raft
a	0045540	biological_process	regulation of cholesterol biosynthetic process
a	0045541	biological_process	negative regulation of cholesterol biosynthetic process
a	0045717	biological_process	negative regulation of fatty acid biosynthetic process
A	0005515	molecular_function	protein binding
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006629	biological_process	lipid metabolic process
A	0008202	biological_process	steroid metabolic process
A	0008203	biological_process	cholesterol metabolic process
A	0008289	molecular_function	lipid binding
A	0015485	molecular_function	cholesterol binding
A	0032933	biological_process	SREBP signaling pathway
A	0032991	cellular_component	protein-containing complex
A	0036503	biological_process	ERAD pathway
A	0045121	cellular_component	membrane raft
A	0045540	biological_process	regulation of cholesterol biosynthetic process
A	0045541	biological_process	negative regulation of cholesterol biosynthetic process
A	0045717	biological_process	negative regulation of fatty acid biosynthetic process
b	0005515	molecular_function	protein binding
b	0005783	cellular_component	endoplasmic reticulum
b	0005789	cellular_component	endoplasmic reticulum membrane
b	0005886	cellular_component	plasma membrane
b	0006629	biological_process	lipid metabolic process
b	0008202	biological_process	steroid metabolic process
b	0008203	biological_process	cholesterol metabolic process
b	0015485	molecular_function	cholesterol binding
b	0031625	molecular_function	ubiquitin protein ligase binding
b	0032933	biological_process	SREBP signaling pathway
b	0032991	cellular_component	protein-containing complex
b	0036503	biological_process	ERAD pathway
b	0045121	cellular_component	membrane raft
b	0045540	biological_process	regulation of cholesterol biosynthetic process
b	0045541	biological_process	negative regulation of cholesterol biosynthetic process
b	0045717	biological_process	negative regulation of fatty acid biosynthetic process
B	0005515	molecular_function	protein binding
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0006629	biological_process	lipid metabolic process
B	0008202	biological_process	steroid metabolic process
B	0008203	biological_process	cholesterol metabolic process
B	0008289	molecular_function	lipid binding
B	0015485	molecular_function	cholesterol binding
B	0032933	biological_process	SREBP signaling pathway
B	0032991	cellular_component	protein-containing complex
B	0036503	biological_process	ERAD pathway
B	0045121	cellular_component	membrane raft
B	0045540	biological_process	regulation of cholesterol biosynthetic process
B	0045541	biological_process	negative regulation of cholesterol biosynthetic process
B	0045717	biological_process	negative regulation of fatty acid biosynthetic process
c	0005515	molecular_function	protein binding
c	0005783	cellular_component	endoplasmic reticulum
c	0005789	cellular_component	endoplasmic reticulum membrane
c	0005886	cellular_component	plasma membrane
c	0006629	biological_process	lipid metabolic process
c	0008202	biological_process	steroid metabolic process
c	0008203	biological_process	cholesterol metabolic process
c	0015485	molecular_function	cholesterol binding
c	0031625	molecular_function	ubiquitin protein ligase binding
c	0032933	biological_process	SREBP signaling pathway
c	0032991	cellular_component	protein-containing complex
c	0036503	biological_process	ERAD pathway
c	0045121	cellular_component	membrane raft
c	0045540	biological_process	regulation of cholesterol biosynthetic process
c	0045541	biological_process	negative regulation of cholesterol biosynthetic process
c	0045717	biological_process	negative regulation of fatty acid biosynthetic process
C	0005515	molecular_function	protein binding
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0006629	biological_process	lipid metabolic process
C	0008202	biological_process	steroid metabolic process
C	0008203	biological_process	cholesterol metabolic process
C	0008289	molecular_function	lipid binding
C	0015485	molecular_function	cholesterol binding
C	0032933	biological_process	SREBP signaling pathway
C	0032991	cellular_component	protein-containing complex
C	0036503	biological_process	ERAD pathway
C	0045121	cellular_component	membrane raft
C	0045540	biological_process	regulation of cholesterol biosynthetic process
C	0045541	biological_process	negative regulation of cholesterol biosynthetic process
C	0045717	biological_process	negative regulation of fatty acid biosynthetic process
d	0005515	molecular_function	protein binding
d	0005783	cellular_component	endoplasmic reticulum
d	0005789	cellular_component	endoplasmic reticulum membrane
d	0005886	cellular_component	plasma membrane
d	0006629	biological_process	lipid metabolic process
d	0008202	biological_process	steroid metabolic process
d	0008203	biological_process	cholesterol metabolic process
d	0015485	molecular_function	cholesterol binding
d	0031625	molecular_function	ubiquitin protein ligase binding
d	0032933	biological_process	SREBP signaling pathway
d	0032991	cellular_component	protein-containing complex
d	0036503	biological_process	ERAD pathway
d	0045121	cellular_component	membrane raft
d	0045540	biological_process	regulation of cholesterol biosynthetic process
d	0045541	biological_process	negative regulation of cholesterol biosynthetic process
d	0045717	biological_process	negative regulation of fatty acid biosynthetic process
D	0005515	molecular_function	protein binding
D	0005783	cellular_component	endoplasmic reticulum
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0006629	biological_process	lipid metabolic process
D	0008202	biological_process	steroid metabolic process
D	0008203	biological_process	cholesterol metabolic process
D	0008289	molecular_function	lipid binding
D	0015485	molecular_function	cholesterol binding
D	0032933	biological_process	SREBP signaling pathway
D	0032991	cellular_component	protein-containing complex
D	0036503	biological_process	ERAD pathway
D	0045121	cellular_component	membrane raft
D	0045540	biological_process	regulation of cholesterol biosynthetic process
D	0045541	biological_process	negative regulation of cholesterol biosynthetic process
D	0045717	biological_process	negative regulation of fatty acid biosynthetic process
e	0005515	molecular_function	protein binding
e	0005783	cellular_component	endoplasmic reticulum
e	0005789	cellular_component	endoplasmic reticulum membrane
e	0005886	cellular_component	plasma membrane
e	0006629	biological_process	lipid metabolic process
e	0008202	biological_process	steroid metabolic process
e	0008203	biological_process	cholesterol metabolic process
e	0015485	molecular_function	cholesterol binding
e	0031625	molecular_function	ubiquitin protein ligase binding
e	0032933	biological_process	SREBP signaling pathway
e	0032991	cellular_component	protein-containing complex
e	0036503	biological_process	ERAD pathway
e	0045121	cellular_component	membrane raft
e	0045540	biological_process	regulation of cholesterol biosynthetic process
e	0045541	biological_process	negative regulation of cholesterol biosynthetic process
e	0045717	biological_process	negative regulation of fatty acid biosynthetic process
E	0005515	molecular_function	protein binding
E	0005783	cellular_component	endoplasmic reticulum
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0006629	biological_process	lipid metabolic process
E	0008202	biological_process	steroid metabolic process
E	0008203	biological_process	cholesterol metabolic process
E	0008289	molecular_function	lipid binding
E	0015485	molecular_function	cholesterol binding
E	0032933	biological_process	SREBP signaling pathway
E	0032991	cellular_component	protein-containing complex
E	0036503	biological_process	ERAD pathway
E	0045121	cellular_component	membrane raft
E	0045540	biological_process	regulation of cholesterol biosynthetic process
E	0045541	biological_process	negative regulation of cholesterol biosynthetic process
E	0045717	biological_process	negative regulation of fatty acid biosynthetic process
f	0005515	molecular_function	protein binding
f	0005783	cellular_component	endoplasmic reticulum
f	0005789	cellular_component	endoplasmic reticulum membrane
f	0005886	cellular_component	plasma membrane
f	0006629	biological_process	lipid metabolic process
f	0008202	biological_process	steroid metabolic process
f	0008203	biological_process	cholesterol metabolic process
f	0015485	molecular_function	cholesterol binding
f	0031625	molecular_function	ubiquitin protein ligase binding
f	0032933	biological_process	SREBP signaling pathway
f	0032991	cellular_component	protein-containing complex
f	0036503	biological_process	ERAD pathway
f	0045121	cellular_component	membrane raft
f	0045540	biological_process	regulation of cholesterol biosynthetic process
f	0045541	biological_process	negative regulation of cholesterol biosynthetic process
f	0045717	biological_process	negative regulation of fatty acid biosynthetic process
F	0005515	molecular_function	protein binding
F	0005783	cellular_component	endoplasmic reticulum
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0006629	biological_process	lipid metabolic process
F	0008202	biological_process	steroid metabolic process
F	0008203	biological_process	cholesterol metabolic process
F	0008289	molecular_function	lipid binding
F	0015485	molecular_function	cholesterol binding
F	0032933	biological_process	SREBP signaling pathway
F	0032991	cellular_component	protein-containing complex
F	0036503	biological_process	ERAD pathway
F	0045121	cellular_component	membrane raft
F	0045540	biological_process	regulation of cholesterol biosynthetic process
F	0045541	biological_process	negative regulation of cholesterol biosynthetic process
F	0045717	biological_process	negative regulation of fatty acid biosynthetic process
g	0005515	molecular_function	protein binding
g	0005783	cellular_component	endoplasmic reticulum
g	0005789	cellular_component	endoplasmic reticulum membrane
g	0005886	cellular_component	plasma membrane
g	0006629	biological_process	lipid metabolic process
g	0008202	biological_process	steroid metabolic process
g	0008203	biological_process	cholesterol metabolic process
g	0015485	molecular_function	cholesterol binding
g	0031625	molecular_function	ubiquitin protein ligase binding
g	0032933	biological_process	SREBP signaling pathway
g	0032991	cellular_component	protein-containing complex
g	0036503	biological_process	ERAD pathway
g	0045121	cellular_component	membrane raft
g	0045540	biological_process	regulation of cholesterol biosynthetic process
g	0045541	biological_process	negative regulation of cholesterol biosynthetic process
g	0045717	biological_process	negative regulation of fatty acid biosynthetic process
G	0005515	molecular_function	protein binding
G	0005783	cellular_component	endoplasmic reticulum
G	0005789	cellular_component	endoplasmic reticulum membrane
G	0006629	biological_process	lipid metabolic process
G	0008202	biological_process	steroid metabolic process
G	0008203	biological_process	cholesterol metabolic process
G	0008289	molecular_function	lipid binding
G	0015485	molecular_function	cholesterol binding
G	0032933	biological_process	SREBP signaling pathway
G	0032991	cellular_component	protein-containing complex
G	0036503	biological_process	ERAD pathway
G	0045121	cellular_component	membrane raft
G	0045540	biological_process	regulation of cholesterol biosynthetic process
G	0045541	biological_process	negative regulation of cholesterol biosynthetic process
G	0045717	biological_process	negative regulation of fatty acid biosynthetic process
h	0005515	molecular_function	protein binding
h	0005783	cellular_component	endoplasmic reticulum
h	0005789	cellular_component	endoplasmic reticulum membrane
h	0005886	cellular_component	plasma membrane
h	0006629	biological_process	lipid metabolic process
h	0008202	biological_process	steroid metabolic process
h	0008203	biological_process	cholesterol metabolic process
h	0015485	molecular_function	cholesterol binding
h	0031625	molecular_function	ubiquitin protein ligase binding
h	0032933	biological_process	SREBP signaling pathway
h	0032991	cellular_component	protein-containing complex
h	0036503	biological_process	ERAD pathway
h	0045121	cellular_component	membrane raft
h	0045540	biological_process	regulation of cholesterol biosynthetic process
h	0045541	biological_process	negative regulation of cholesterol biosynthetic process
h	0045717	biological_process	negative regulation of fatty acid biosynthetic process
H	0005515	molecular_function	protein binding
H	0005783	cellular_component	endoplasmic reticulum
H	0005789	cellular_component	endoplasmic reticulum membrane
H	0006629	biological_process	lipid metabolic process
H	0008202	biological_process	steroid metabolic process
H	0008203	biological_process	cholesterol metabolic process
H	0008289	molecular_function	lipid binding
H	0015485	molecular_function	cholesterol binding
H	0032933	biological_process	SREBP signaling pathway
H	0032991	cellular_component	protein-containing complex
H	0036503	biological_process	ERAD pathway
H	0045121	cellular_component	membrane raft
H	0045540	biological_process	regulation of cholesterol biosynthetic process
H	0045541	biological_process	negative regulation of cholesterol biosynthetic process
H	0045717	biological_process	negative regulation of fatty acid biosynthetic process
i	0005515	molecular_function	protein binding
i	0005783	cellular_component	endoplasmic reticulum
i	0005789	cellular_component	endoplasmic reticulum membrane
i	0005886	cellular_component	plasma membrane
i	0006629	biological_process	lipid metabolic process
i	0008202	biological_process	steroid metabolic process
i	0008203	biological_process	cholesterol metabolic process
i	0015485	molecular_function	cholesterol binding
i	0031625	molecular_function	ubiquitin protein ligase binding
i	0032933	biological_process	SREBP signaling pathway
i	0032991	cellular_component	protein-containing complex
i	0036503	biological_process	ERAD pathway
i	0045121	cellular_component	membrane raft
i	0045540	biological_process	regulation of cholesterol biosynthetic process
i	0045541	biological_process	negative regulation of cholesterol biosynthetic process
i	0045717	biological_process	negative regulation of fatty acid biosynthetic process
I	0005515	molecular_function	protein binding
I	0005783	cellular_component	endoplasmic reticulum
I	0005789	cellular_component	endoplasmic reticulum membrane
I	0006629	biological_process	lipid metabolic process
I	0008202	biological_process	steroid metabolic process
I	0008203	biological_process	cholesterol metabolic process
I	0008289	molecular_function	lipid binding
I	0015485	molecular_function	cholesterol binding
I	0032933	biological_process	SREBP signaling pathway
I	0032991	cellular_component	protein-containing complex
I	0036503	biological_process	ERAD pathway
I	0045121	cellular_component	membrane raft
I	0045540	biological_process	regulation of cholesterol biosynthetic process
I	0045541	biological_process	negative regulation of cholesterol biosynthetic process
I	0045717	biological_process	negative regulation of fatty acid biosynthetic process
j	0005515	molecular_function	protein binding
j	0005783	cellular_component	endoplasmic reticulum
j	0005789	cellular_component	endoplasmic reticulum membrane
j	0005886	cellular_component	plasma membrane
j	0006629	biological_process	lipid metabolic process
j	0008202	biological_process	steroid metabolic process
j	0008203	biological_process	cholesterol metabolic process
j	0015485	molecular_function	cholesterol binding
j	0031625	molecular_function	ubiquitin protein ligase binding
j	0032933	biological_process	SREBP signaling pathway
j	0032991	cellular_component	protein-containing complex
j	0036503	biological_process	ERAD pathway
j	0045121	cellular_component	membrane raft
j	0045540	biological_process	regulation of cholesterol biosynthetic process
j	0045541	biological_process	negative regulation of cholesterol biosynthetic process
j	0045717	biological_process	negative regulation of fatty acid biosynthetic process
J	0005515	molecular_function	protein binding
J	0005783	cellular_component	endoplasmic reticulum
J	0005789	cellular_component	endoplasmic reticulum membrane
J	0006629	biological_process	lipid metabolic process
J	0008202	biological_process	steroid metabolic process
J	0008203	biological_process	cholesterol metabolic process
J	0008289	molecular_function	lipid binding
J	0015485	molecular_function	cholesterol binding
J	0032933	biological_process	SREBP signaling pathway
J	0032991	cellular_component	protein-containing complex
J	0036503	biological_process	ERAD pathway
J	0045121	cellular_component	membrane raft
J	0045540	biological_process	regulation of cholesterol biosynthetic process
J	0045541	biological_process	negative regulation of cholesterol biosynthetic process
J	0045717	biological_process	negative regulation of fatty acid biosynthetic process
k	0005515	molecular_function	protein binding
k	0005783	cellular_component	endoplasmic reticulum
k	0005789	cellular_component	endoplasmic reticulum membrane
k	0005886	cellular_component	plasma membrane
k	0006629	biological_process	lipid metabolic process
k	0008202	biological_process	steroid metabolic process
k	0008203	biological_process	cholesterol metabolic process
k	0015485	molecular_function	cholesterol binding
k	0031625	molecular_function	ubiquitin protein ligase binding
k	0032933	biological_process	SREBP signaling pathway
k	0032991	cellular_component	protein-containing complex
k	0036503	biological_process	ERAD pathway
k	0045121	cellular_component	membrane raft
k	0045540	biological_process	regulation of cholesterol biosynthetic process
k	0045541	biological_process	negative regulation of cholesterol biosynthetic process
k	0045717	biological_process	negative regulation of fatty acid biosynthetic process
K	0005515	molecular_function	protein binding
K	0005783	cellular_component	endoplasmic reticulum
K	0005789	cellular_component	endoplasmic reticulum membrane
K	0006629	biological_process	lipid metabolic process
K	0008202	biological_process	steroid metabolic process
K	0008203	biological_process	cholesterol metabolic process
K	0008289	molecular_function	lipid binding
K	0015485	molecular_function	cholesterol binding
K	0032933	biological_process	SREBP signaling pathway
K	0032991	cellular_component	protein-containing complex
K	0036503	biological_process	ERAD pathway
K	0045121	cellular_component	membrane raft
K	0045540	biological_process	regulation of cholesterol biosynthetic process
K	0045541	biological_process	negative regulation of cholesterol biosynthetic process
K	0045717	biological_process	negative regulation of fatty acid biosynthetic process
l	0005515	molecular_function	protein binding
l	0005783	cellular_component	endoplasmic reticulum
l	0005789	cellular_component	endoplasmic reticulum membrane
l	0005886	cellular_component	plasma membrane
l	0006629	biological_process	lipid metabolic process
l	0008202	biological_process	steroid metabolic process
l	0008203	biological_process	cholesterol metabolic process
l	0015485	molecular_function	cholesterol binding
l	0031625	molecular_function	ubiquitin protein ligase binding
l	0032933	biological_process	SREBP signaling pathway
l	0032991	cellular_component	protein-containing complex
l	0036503	biological_process	ERAD pathway
l	0045121	cellular_component	membrane raft
l	0045540	biological_process	regulation of cholesterol biosynthetic process
l	0045541	biological_process	negative regulation of cholesterol biosynthetic process
l	0045717	biological_process	negative regulation of fatty acid biosynthetic process
L	0005515	molecular_function	protein binding
L	0005783	cellular_component	endoplasmic reticulum
L	0005789	cellular_component	endoplasmic reticulum membrane
L	0006629	biological_process	lipid metabolic process
L	0008202	biological_process	steroid metabolic process
L	0008203	biological_process	cholesterol metabolic process
L	0008289	molecular_function	lipid binding
L	0015485	molecular_function	cholesterol binding
L	0032933	biological_process	SREBP signaling pathway
L	0032991	cellular_component	protein-containing complex
L	0036503	biological_process	ERAD pathway
L	0045121	cellular_component	membrane raft
L	0045540	biological_process	regulation of cholesterol biosynthetic process
L	0045541	biological_process	negative regulation of cholesterol biosynthetic process
L	0045717	biological_process	negative regulation of fatty acid biosynthetic process
m	0005515	molecular_function	protein binding
m	0005783	cellular_component	endoplasmic reticulum
m	0005789	cellular_component	endoplasmic reticulum membrane
m	0005886	cellular_component	plasma membrane
m	0006629	biological_process	lipid metabolic process
m	0008202	biological_process	steroid metabolic process
m	0008203	biological_process	cholesterol metabolic process
m	0015485	molecular_function	cholesterol binding
m	0031625	molecular_function	ubiquitin protein ligase binding
m	0032933	biological_process	SREBP signaling pathway
m	0032991	cellular_component	protein-containing complex
m	0036503	biological_process	ERAD pathway
m	0045121	cellular_component	membrane raft
m	0045540	biological_process	regulation of cholesterol biosynthetic process
m	0045541	biological_process	negative regulation of cholesterol biosynthetic process
m	0045717	biological_process	negative regulation of fatty acid biosynthetic process
M	0005515	molecular_function	protein binding
M	0005783	cellular_component	endoplasmic reticulum
M	0005789	cellular_component	endoplasmic reticulum membrane
M	0006629	biological_process	lipid metabolic process
M	0008202	biological_process	steroid metabolic process
M	0008203	biological_process	cholesterol metabolic process
M	0008289	molecular_function	lipid binding
M	0015485	molecular_function	cholesterol binding
M	0032933	biological_process	SREBP signaling pathway
M	0032991	cellular_component	protein-containing complex
M	0036503	biological_process	ERAD pathway
M	0045121	cellular_component	membrane raft
M	0045540	biological_process	regulation of cholesterol biosynthetic process
M	0045541	biological_process	negative regulation of cholesterol biosynthetic process
M	0045717	biological_process	negative regulation of fatty acid biosynthetic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	13
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	13
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	13
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"O75477","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	13
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"17502376","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---