9O97
Cryo-EM structure of CLC-ec1 at pH 3.0
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 432 |
| Details | Transmembrane: {"description":"Helical"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 106 |
| Details | Topological domain: {"description":"Periplasmic"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 104 |
| Details | Intramembrane: {"description":"Helical"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 64 |
| Details | Topological domain: {"description":"Cytoplasmic"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | Intramembrane: {"description":"Note=Loop between two helices"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Selectivity filter part_1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Selectivity filter part_2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Selectivity filter part_3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12649487","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16341087","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"18678918","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1OTT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OTU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12649487","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1OTS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ENE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6LSC","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12649487","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1OTT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12649487","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1OTS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OTT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OTU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ENE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6LSC","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | Site: {"description":"Mediates proton transfer from the outer aqueous phase to the interior of the protein; involved in linking H(+) and Cl(-) transport"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | Site: {"description":"Mediates proton transfer from the protein to the inner aqueous phase"} |
| Chain | Residue | Details |
