9O94
Transporter associated with antigen processing (TAP) EQ mutant bound to the viral protein bUL49.5 in the outward-facing kinked state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0002250 | biological_process | adaptive immune response |
| A | 0002376 | biological_process | immune system process |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0006952 | biological_process | defense response |
| A | 0015031 | biological_process | protein transport |
| A | 0015433 | molecular_function | ABC-type peptide antigen transporter activity |
| A | 0015440 | molecular_function | ABC-type peptide transporter activity |
| A | 0015833 | biological_process | peptide transport |
| A | 0016020 | cellular_component | membrane |
| A | 0019885 | biological_process | antigen processing and presentation of endogenous peptide antigen via MHC class I |
| A | 0023029 | molecular_function | MHC class Ib protein binding |
| A | 0030670 | cellular_component | phagocytic vesicle membrane |
| A | 0031090 | cellular_component | organelle membrane |
| A | 0033116 | cellular_component | endoplasmic reticulum-Golgi intermediate compartment membrane |
| A | 0042287 | molecular_function | MHC protein binding |
| A | 0042288 | molecular_function | MHC class I protein binding |
| A | 0042605 | molecular_function | peptide antigen binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0042824 | cellular_component | MHC class I peptide loading complex |
| A | 0042825 | cellular_component | TAP complex |
| A | 0043531 | molecular_function | ADP binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0046967 | biological_process | cytosol to endoplasmic reticulum transport |
| A | 0046978 | molecular_function | TAP1 binding |
| A | 0046979 | molecular_function | TAP2 binding |
| A | 0055085 | biological_process | transmembrane transport |
| A | 1904680 | molecular_function | peptide transmembrane transporter activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0002250 | biological_process | adaptive immune response |
| B | 0002376 | biological_process | immune system process |
| B | 0002489 | biological_process | antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0006952 | biological_process | defense response |
| B | 0015031 | biological_process | protein transport |
| B | 0015433 | molecular_function | ABC-type peptide antigen transporter activity |
| B | 0015440 | molecular_function | ABC-type peptide transporter activity |
| B | 0015833 | biological_process | peptide transport |
| B | 0016020 | cellular_component | membrane |
| B | 0019885 | biological_process | antigen processing and presentation of endogenous peptide antigen via MHC class I |
| B | 0023029 | molecular_function | MHC class Ib protein binding |
| B | 0030670 | cellular_component | phagocytic vesicle membrane |
| B | 0033116 | cellular_component | endoplasmic reticulum-Golgi intermediate compartment membrane |
| B | 0042605 | molecular_function | peptide antigen binding |
| B | 0042824 | cellular_component | MHC class I peptide loading complex |
| B | 0042825 | cellular_component | TAP complex |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0046967 | biological_process | cytosol to endoplasmic reticulum transport |
| B | 0046968 | biological_process | peptide antigen transport |
| B | 0046978 | molecular_function | TAP1 binding |
| B | 0046980 | molecular_function | tapasin binding |
| B | 0055085 | biological_process | transmembrane transport |
| B | 1904680 | molecular_function | peptide transmembrane transporter activity |
Functional Information from PROSITE/UniProt
| site_id | PS00211 |
| Number of Residues | 15 |
| Details | ABC_TRANSPORTER_1 ABC transporters family signature. LAAGQKQRLAIARAL |
| Chain | Residue | Details |
| B | LEU607-LEU621 | |
| A | LEU643-LEU657 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 233 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 33 |
| Details | Topological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 239 |
| Details | Domain: {"description":"ABC transporter","evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 186 |
| Details | Region: {"description":"Part of the peptide-binding site","evidences":[{"source":"PubMed","id":"8955196","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P36370","evidenceCode":"ECO:0000250"},{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11532960","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1JJ7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P36370","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
