9O7R
Crystal structure of human adenosine kinase (ADK) in complex with inhibitor BKI-1553
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004001 | molecular_function | adenosine kinase activity |
| A | 0004136 | molecular_function | deoxyadenosine kinase activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006144 | biological_process | purine nucleobase metabolic process |
| A | 0006170 | biological_process | dAMP biosynthetic process |
| A | 0009156 | biological_process | ribonucleoside monophosphate biosynthetic process |
| A | 0032261 | biological_process | purine nucleotide salvage |
| A | 0032263 | biological_process | GMP salvage |
| A | 0044209 | biological_process | AMP salvage |
| A | 0110052 | biological_process | toxic metabolite repair |
Functional Information from PROSITE/UniProt
| site_id | PS00584 |
| Number of Residues | 14 |
| Details | PFKB_KINASES_2 pfkB family of carbohydrate kinases signature 2. DTnGAGDafvGGFL |
| Chain | Residue | Details |
| A | ASP294-LEU307 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"9843365","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BX4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"9843365","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BX4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"12112843","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
