9O3R

Crystal Structure of I64A Variant of D-Dopachrome Tautomerase (D-DT)

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0004167	molecular_function	dopachrome isomerase activity
AAA	0005126	molecular_function	cytokine receptor binding
AAA	0005576	cellular_component	extracellular region
AAA	0005737	cellular_component	cytoplasm
AAA	0010760	biological_process	negative regulation of macrophage chemotaxis
AAA	0032760	biological_process	positive regulation of tumor necrosis factor production
AAA	0033981	molecular_function	D-dopachrome decarboxylase activity
AAA	0050178	molecular_function	phenylpyruvate tautomerase activity
AAA	0050729	biological_process	positive regulation of inflammatory response
AAA	0070062	cellular_component	extracellular exosome
AAA	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
BBB	0004167	molecular_function	dopachrome isomerase activity
BBB	0005126	molecular_function	cytokine receptor binding
BBB	0005576	cellular_component	extracellular region
BBB	0005737	cellular_component	cytoplasm
BBB	0010760	biological_process	negative regulation of macrophage chemotaxis
BBB	0032760	biological_process	positive regulation of tumor necrosis factor production
BBB	0033981	molecular_function	D-dopachrome decarboxylase activity
BBB	0050178	molecular_function	phenylpyruvate tautomerase activity
BBB	0050729	biological_process	positive regulation of inflammatory response
BBB	0070062	cellular_component	extracellular exosome
BBB	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
CCC	0004167	molecular_function	dopachrome isomerase activity
CCC	0005126	molecular_function	cytokine receptor binding
CCC	0005576	cellular_component	extracellular region
CCC	0005737	cellular_component	cytoplasm
CCC	0010760	biological_process	negative regulation of macrophage chemotaxis
CCC	0032760	biological_process	positive regulation of tumor necrosis factor production
CCC	0033981	molecular_function	D-dopachrome decarboxylase activity
CCC	0050178	molecular_function	phenylpyruvate tautomerase activity
CCC	0050729	biological_process	positive regulation of inflammatory response
CCC	0070062	cellular_component	extracellular exosome
CCC	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
DDD	0004167	molecular_function	dopachrome isomerase activity
DDD	0005126	molecular_function	cytokine receptor binding
DDD	0005576	cellular_component	extracellular region
DDD	0005737	cellular_component	cytoplasm
DDD	0010760	biological_process	negative regulation of macrophage chemotaxis
DDD	0032760	biological_process	positive regulation of tumor necrosis factor production
DDD	0033981	molecular_function	D-dopachrome decarboxylase activity
DDD	0050178	molecular_function	phenylpyruvate tautomerase activity
DDD	0050729	biological_process	positive regulation of inflammatory response
DDD	0070062	cellular_component	extracellular exosome
DDD	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
EEE	0004167	molecular_function	dopachrome isomerase activity
EEE	0005126	molecular_function	cytokine receptor binding
EEE	0005576	cellular_component	extracellular region
EEE	0005737	cellular_component	cytoplasm
EEE	0010760	biological_process	negative regulation of macrophage chemotaxis
EEE	0032760	biological_process	positive regulation of tumor necrosis factor production
EEE	0033981	molecular_function	D-dopachrome decarboxylase activity
EEE	0050178	molecular_function	phenylpyruvate tautomerase activity
EEE	0050729	biological_process	positive regulation of inflammatory response
EEE	0070062	cellular_component	extracellular exosome
EEE	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
FFF	0004167	molecular_function	dopachrome isomerase activity
FFF	0005126	molecular_function	cytokine receptor binding
FFF	0005576	cellular_component	extracellular region
FFF	0005737	cellular_component	cytoplasm
FFF	0010760	biological_process	negative regulation of macrophage chemotaxis
FFF	0032760	biological_process	positive regulation of tumor necrosis factor production
FFF	0033981	molecular_function	D-dopachrome decarboxylase activity
FFF	0050178	molecular_function	phenylpyruvate tautomerase activity
FFF	0050729	biological_process	positive regulation of inflammatory response
FFF	0070062	cellular_component	extracellular exosome
FFF	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
GGG	0004167	molecular_function	dopachrome isomerase activity
GGG	0005126	molecular_function	cytokine receptor binding
GGG	0005576	cellular_component	extracellular region
GGG	0005737	cellular_component	cytoplasm
GGG	0010760	biological_process	negative regulation of macrophage chemotaxis
GGG	0032760	biological_process	positive regulation of tumor necrosis factor production
GGG	0033981	molecular_function	D-dopachrome decarboxylase activity
GGG	0050178	molecular_function	phenylpyruvate tautomerase activity
GGG	0050729	biological_process	positive regulation of inflammatory response
GGG	0070062	cellular_component	extracellular exosome
GGG	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
HHH	0004167	molecular_function	dopachrome isomerase activity
HHH	0005126	molecular_function	cytokine receptor binding
HHH	0005576	cellular_component	extracellular region
HHH	0005737	cellular_component	cytoplasm
HHH	0010760	biological_process	negative regulation of macrophage chemotaxis
HHH	0032760	biological_process	positive regulation of tumor necrosis factor production
HHH	0033981	molecular_function	D-dopachrome decarboxylase activity
HHH	0050178	molecular_function	phenylpyruvate tautomerase activity
HHH	0050729	biological_process	positive regulation of inflammatory response
HHH	0070062	cellular_component	extracellular exosome
HHH	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
III	0004167	molecular_function	dopachrome isomerase activity
III	0005126	molecular_function	cytokine receptor binding
III	0005576	cellular_component	extracellular region
III	0005737	cellular_component	cytoplasm
III	0010760	biological_process	negative regulation of macrophage chemotaxis
III	0032760	biological_process	positive regulation of tumor necrosis factor production
III	0033981	molecular_function	D-dopachrome decarboxylase activity
III	0050178	molecular_function	phenylpyruvate tautomerase activity
III	0050729	biological_process	positive regulation of inflammatory response
III	0070062	cellular_component	extracellular exosome
III	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
JJJ	0004167	molecular_function	dopachrome isomerase activity
JJJ	0005126	molecular_function	cytokine receptor binding
JJJ	0005576	cellular_component	extracellular region
JJJ	0005737	cellular_component	cytoplasm
JJJ	0010760	biological_process	negative regulation of macrophage chemotaxis
JJJ	0032760	biological_process	positive regulation of tumor necrosis factor production
JJJ	0033981	molecular_function	D-dopachrome decarboxylase activity
JJJ	0050178	molecular_function	phenylpyruvate tautomerase activity
JJJ	0050729	biological_process	positive regulation of inflammatory response
JJJ	0070062	cellular_component	extracellular exosome
JJJ	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
KKK	0004167	molecular_function	dopachrome isomerase activity
KKK	0005126	molecular_function	cytokine receptor binding
KKK	0005576	cellular_component	extracellular region
KKK	0005737	cellular_component	cytoplasm
KKK	0010760	biological_process	negative regulation of macrophage chemotaxis
KKK	0032760	biological_process	positive regulation of tumor necrosis factor production
KKK	0033981	molecular_function	D-dopachrome decarboxylase activity
KKK	0050178	molecular_function	phenylpyruvate tautomerase activity
KKK	0050729	biological_process	positive regulation of inflammatory response
KKK	0070062	cellular_component	extracellular exosome
KKK	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
LLL	0004167	molecular_function	dopachrome isomerase activity
LLL	0005126	molecular_function	cytokine receptor binding
LLL	0005576	cellular_component	extracellular region
LLL	0005737	cellular_component	cytoplasm
LLL	0010760	biological_process	negative regulation of macrophage chemotaxis
LLL	0032760	biological_process	positive regulation of tumor necrosis factor production
LLL	0033981	molecular_function	D-dopachrome decarboxylase activity
LLL	0050178	molecular_function	phenylpyruvate tautomerase activity
LLL	0050729	biological_process	positive regulation of inflammatory response
LLL	0070062	cellular_component	extracellular exosome
LLL	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
MMM	0004167	molecular_function	dopachrome isomerase activity
MMM	0005126	molecular_function	cytokine receptor binding
MMM	0005576	cellular_component	extracellular region
MMM	0005737	cellular_component	cytoplasm
MMM	0010760	biological_process	negative regulation of macrophage chemotaxis
MMM	0032760	biological_process	positive regulation of tumor necrosis factor production
MMM	0033981	molecular_function	D-dopachrome decarboxylase activity
MMM	0050178	molecular_function	phenylpyruvate tautomerase activity
MMM	0050729	biological_process	positive regulation of inflammatory response
MMM	0070062	cellular_component	extracellular exosome
MMM	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
NNN	0004167	molecular_function	dopachrome isomerase activity
NNN	0005126	molecular_function	cytokine receptor binding
NNN	0005576	cellular_component	extracellular region
NNN	0005737	cellular_component	cytoplasm
NNN	0010760	biological_process	negative regulation of macrophage chemotaxis
NNN	0032760	biological_process	positive regulation of tumor necrosis factor production
NNN	0033981	molecular_function	D-dopachrome decarboxylase activity
NNN	0050178	molecular_function	phenylpyruvate tautomerase activity
NNN	0050729	biological_process	positive regulation of inflammatory response
NNN	0070062	cellular_component	extracellular exosome
NNN	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
OOO	0004167	molecular_function	dopachrome isomerase activity
OOO	0005126	molecular_function	cytokine receptor binding
OOO	0005576	cellular_component	extracellular region
OOO	0005737	cellular_component	cytoplasm
OOO	0010760	biological_process	negative regulation of macrophage chemotaxis
OOO	0032760	biological_process	positive regulation of tumor necrosis factor production
OOO	0033981	molecular_function	D-dopachrome decarboxylase activity
OOO	0050178	molecular_function	phenylpyruvate tautomerase activity
OOO	0050729	biological_process	positive regulation of inflammatory response
OOO	0070062	cellular_component	extracellular exosome
OOO	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
PPP	0004167	molecular_function	dopachrome isomerase activity
PPP	0005126	molecular_function	cytokine receptor binding
PPP	0005576	cellular_component	extracellular region
PPP	0005737	cellular_component	cytoplasm
PPP	0010760	biological_process	negative regulation of macrophage chemotaxis
PPP	0032760	biological_process	positive regulation of tumor necrosis factor production
PPP	0033981	molecular_function	D-dopachrome decarboxylase activity
PPP	0050178	molecular_function	phenylpyruvate tautomerase activity
PPP	0050729	biological_process	positive regulation of inflammatory response
PPP	0070062	cellular_component	extracellular exosome
PPP	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
QQQ	0004167	molecular_function	dopachrome isomerase activity
QQQ	0005126	molecular_function	cytokine receptor binding
QQQ	0005576	cellular_component	extracellular region
QQQ	0005737	cellular_component	cytoplasm
QQQ	0010760	biological_process	negative regulation of macrophage chemotaxis
QQQ	0032760	biological_process	positive regulation of tumor necrosis factor production
QQQ	0033981	molecular_function	D-dopachrome decarboxylase activity
QQQ	0050178	molecular_function	phenylpyruvate tautomerase activity
QQQ	0050729	biological_process	positive regulation of inflammatory response
QQQ	0070062	cellular_component	extracellular exosome
QQQ	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
RRR	0004167	molecular_function	dopachrome isomerase activity
RRR	0005126	molecular_function	cytokine receptor binding
RRR	0005576	cellular_component	extracellular region
RRR	0005737	cellular_component	cytoplasm
RRR	0010760	biological_process	negative regulation of macrophage chemotaxis
RRR	0032760	biological_process	positive regulation of tumor necrosis factor production
RRR	0033981	molecular_function	D-dopachrome decarboxylase activity
RRR	0050178	molecular_function	phenylpyruvate tautomerase activity
RRR	0050729	biological_process	positive regulation of inflammatory response
RRR	0070062	cellular_component	extracellular exosome
RRR	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	Modified residue: {"description":"N-acetylproline","evidences":[{"source":"UniProtKB","id":"O35215","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	18
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"O35215","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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