9O3B

PKM2 bound to MCTI-566

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003723	molecular_function	RNA binding
A	0003729	molecular_function	mRNA binding
A	0003824	molecular_function	catalytic activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
A	0004743	molecular_function	pyruvate kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005791	cellular_component	rough endoplasmic reticulum
A	0005829	cellular_component	cytosol
A	0005929	cellular_component	cilium
A	0006096	biological_process	glycolytic process
A	0006417	biological_process	regulation of translation
A	0012501	biological_process	programmed cell death
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0023026	molecular_function	MHC class II protein complex binding
A	0031982	cellular_component	vesicle
A	0032869	biological_process	cellular response to insulin stimulus
A	0034774	cellular_component	secretory granule lumen
A	0045296	molecular_function	cadherin binding
A	0046872	molecular_function	metal ion binding
A	0061621	biological_process	canonical glycolysis
A	0070062	cellular_component	extracellular exosome
A	1903561	cellular_component	extracellular vesicle
A	1903672	biological_process	positive regulation of sprouting angiogenesis
A	1904813	cellular_component	ficolin-1-rich granule lumen
A	2000767	biological_process	positive regulation of cytoplasmic translation
B	0000166	molecular_function	nucleotide binding
B	0003723	molecular_function	RNA binding
B	0003729	molecular_function	mRNA binding
B	0003824	molecular_function	catalytic activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0004713	molecular_function	protein tyrosine kinase activity
B	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
B	0004743	molecular_function	pyruvate kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005791	cellular_component	rough endoplasmic reticulum
B	0005829	cellular_component	cytosol
B	0005929	cellular_component	cilium
B	0006096	biological_process	glycolytic process
B	0006417	biological_process	regulation of translation
B	0012501	biological_process	programmed cell death
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0023026	molecular_function	MHC class II protein complex binding
B	0031982	cellular_component	vesicle
B	0032869	biological_process	cellular response to insulin stimulus
B	0034774	cellular_component	secretory granule lumen
B	0045296	molecular_function	cadherin binding
B	0046872	molecular_function	metal ion binding
B	0061621	biological_process	canonical glycolysis
B	0070062	cellular_component	extracellular exosome
B	1903561	cellular_component	extracellular vesicle
B	1903672	biological_process	positive regulation of sprouting angiogenesis
B	1904813	cellular_component	ficolin-1-rich granule lumen
B	2000767	biological_process	positive regulation of cytoplasmic translation
C	0000166	molecular_function	nucleotide binding
C	0003723	molecular_function	RNA binding
C	0003729	molecular_function	mRNA binding
C	0003824	molecular_function	catalytic activity
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0004713	molecular_function	protein tyrosine kinase activity
C	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
C	0004743	molecular_function	pyruvate kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005791	cellular_component	rough endoplasmic reticulum
C	0005829	cellular_component	cytosol
C	0005929	cellular_component	cilium
C	0006096	biological_process	glycolytic process
C	0006417	biological_process	regulation of translation
C	0012501	biological_process	programmed cell death
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0023026	molecular_function	MHC class II protein complex binding
C	0031982	cellular_component	vesicle
C	0032869	biological_process	cellular response to insulin stimulus
C	0034774	cellular_component	secretory granule lumen
C	0045296	molecular_function	cadherin binding
C	0046872	molecular_function	metal ion binding
C	0061621	biological_process	canonical glycolysis
C	0070062	cellular_component	extracellular exosome
C	1903561	cellular_component	extracellular vesicle
C	1903672	biological_process	positive regulation of sprouting angiogenesis
C	1904813	cellular_component	ficolin-1-rich granule lumen
C	2000767	biological_process	positive regulation of cytoplasmic translation
D	0000166	molecular_function	nucleotide binding
D	0003723	molecular_function	RNA binding
D	0003729	molecular_function	mRNA binding
D	0003824	molecular_function	catalytic activity
D	0004674	molecular_function	protein serine/threonine kinase activity
D	0004713	molecular_function	protein tyrosine kinase activity
D	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
D	0004743	molecular_function	pyruvate kinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005791	cellular_component	rough endoplasmic reticulum
D	0005829	cellular_component	cytosol
D	0005929	cellular_component	cilium
D	0006096	biological_process	glycolytic process
D	0006417	biological_process	regulation of translation
D	0012501	biological_process	programmed cell death
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0023026	molecular_function	MHC class II protein complex binding
D	0031982	cellular_component	vesicle
D	0032869	biological_process	cellular response to insulin stimulus
D	0034774	cellular_component	secretory granule lumen
D	0045296	molecular_function	cadherin binding
D	0046872	molecular_function	metal ion binding
D	0061621	biological_process	canonical glycolysis
D	0070062	cellular_component	extracellular exosome
D	1903561	cellular_component	extracellular vesicle
D	1903672	biological_process	positive regulation of sprouting angiogenesis
D	1904813	cellular_component	ficolin-1-rich granule lumen
D	2000767	biological_process	positive regulation of cytoplasmic translation
E	0000166	molecular_function	nucleotide binding
E	0003723	molecular_function	RNA binding
E	0003729	molecular_function	mRNA binding
E	0003824	molecular_function	catalytic activity
E	0004674	molecular_function	protein serine/threonine kinase activity
E	0004713	molecular_function	protein tyrosine kinase activity
E	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
E	0004743	molecular_function	pyruvate kinase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005791	cellular_component	rough endoplasmic reticulum
E	0005829	cellular_component	cytosol
E	0005929	cellular_component	cilium
E	0006096	biological_process	glycolytic process
E	0006417	biological_process	regulation of translation
E	0012501	biological_process	programmed cell death
E	0016301	molecular_function	kinase activity
E	0016740	molecular_function	transferase activity
E	0023026	molecular_function	MHC class II protein complex binding
E	0031982	cellular_component	vesicle
E	0032869	biological_process	cellular response to insulin stimulus
E	0034774	cellular_component	secretory granule lumen
E	0045296	molecular_function	cadherin binding
E	0046872	molecular_function	metal ion binding
E	0061621	biological_process	canonical glycolysis
E	0070062	cellular_component	extracellular exosome
E	1903561	cellular_component	extracellular vesicle
E	1903672	biological_process	positive regulation of sprouting angiogenesis
E	1904813	cellular_component	ficolin-1-rich granule lumen
E	2000767	biological_process	positive regulation of cytoplasmic translation
F	0000166	molecular_function	nucleotide binding
F	0003723	molecular_function	RNA binding
F	0003729	molecular_function	mRNA binding
F	0003824	molecular_function	catalytic activity
F	0004674	molecular_function	protein serine/threonine kinase activity
F	0004713	molecular_function	protein tyrosine kinase activity
F	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
F	0004743	molecular_function	pyruvate kinase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005791	cellular_component	rough endoplasmic reticulum
F	0005829	cellular_component	cytosol
F	0005929	cellular_component	cilium
F	0006096	biological_process	glycolytic process
F	0006417	biological_process	regulation of translation
F	0012501	biological_process	programmed cell death
F	0016301	molecular_function	kinase activity
F	0016740	molecular_function	transferase activity
F	0023026	molecular_function	MHC class II protein complex binding
F	0031982	cellular_component	vesicle
F	0032869	biological_process	cellular response to insulin stimulus
F	0034774	cellular_component	secretory granule lumen
F	0045296	molecular_function	cadherin binding
F	0046872	molecular_function	metal ion binding
F	0061621	biological_process	canonical glycolysis
F	0070062	cellular_component	extracellular exosome
F	1903561	cellular_component	extracellular vesicle
F	1903672	biological_process	positive regulation of sprouting angiogenesis
F	1904813	cellular_component	ficolin-1-rich granule lumen
F	2000767	biological_process	positive regulation of cytoplasmic translation
G	0000166	molecular_function	nucleotide binding
G	0003723	molecular_function	RNA binding
G	0003729	molecular_function	mRNA binding
G	0003824	molecular_function	catalytic activity
G	0004674	molecular_function	protein serine/threonine kinase activity
G	0004713	molecular_function	protein tyrosine kinase activity
G	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
G	0004743	molecular_function	pyruvate kinase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005576	cellular_component	extracellular region
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005791	cellular_component	rough endoplasmic reticulum
G	0005829	cellular_component	cytosol
G	0005929	cellular_component	cilium
G	0006096	biological_process	glycolytic process
G	0006417	biological_process	regulation of translation
G	0012501	biological_process	programmed cell death
G	0016301	molecular_function	kinase activity
G	0016740	molecular_function	transferase activity
G	0023026	molecular_function	MHC class II protein complex binding
G	0031982	cellular_component	vesicle
G	0032869	biological_process	cellular response to insulin stimulus
G	0034774	cellular_component	secretory granule lumen
G	0045296	molecular_function	cadherin binding
G	0046872	molecular_function	metal ion binding
G	0061621	biological_process	canonical glycolysis
G	0070062	cellular_component	extracellular exosome
G	1903561	cellular_component	extracellular vesicle
G	1903672	biological_process	positive regulation of sprouting angiogenesis
G	1904813	cellular_component	ficolin-1-rich granule lumen
G	2000767	biological_process	positive regulation of cytoplasmic translation
H	0000166	molecular_function	nucleotide binding
H	0003723	molecular_function	RNA binding
H	0003729	molecular_function	mRNA binding
H	0003824	molecular_function	catalytic activity
H	0004674	molecular_function	protein serine/threonine kinase activity
H	0004713	molecular_function	protein tyrosine kinase activity
H	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
H	0004743	molecular_function	pyruvate kinase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005576	cellular_component	extracellular region
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005791	cellular_component	rough endoplasmic reticulum
H	0005829	cellular_component	cytosol
H	0005929	cellular_component	cilium
H	0006096	biological_process	glycolytic process
H	0006417	biological_process	regulation of translation
H	0012501	biological_process	programmed cell death
H	0016301	molecular_function	kinase activity
H	0016740	molecular_function	transferase activity
H	0023026	molecular_function	MHC class II protein complex binding
H	0031982	cellular_component	vesicle
H	0032869	biological_process	cellular response to insulin stimulus
H	0034774	cellular_component	secretory granule lumen
H	0045296	molecular_function	cadherin binding
H	0046872	molecular_function	metal ion binding
H	0061621	biological_process	canonical glycolysis
H	0070062	cellular_component	extracellular exosome
H	1903561	cellular_component	extracellular vesicle
H	1903672	biological_process	positive regulation of sprouting angiogenesis
H	1904813	cellular_component	ficolin-1-rich granule lumen
H	2000767	biological_process	positive regulation of cytoplasmic translation

Functional Information from PROSITE/UniProt

site_id	PS00110
Number of Residues	13
Details	PYRUVATE_KINASE Pyruvate kinase active site signature. IkIISKIENhEGV

Chain	Residue	Details
A	ILE265-VAL277

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1344
Details	Region: {"description":"Interaction with POU5F1","evidences":[{"source":"PubMed","id":"18191611","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	352
Details	Region: {"description":"Intersubunit contact"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23064226","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	40
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P30613","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	80
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23530218","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4FXF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	86
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15996096","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23530218","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FXF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"UniProtKB","id":"P00549","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	Site: {"description":"Crucial for phosphotyrosine binding","evidences":[{"source":"PubMed","id":"27199445","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"16964243","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18088087","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	8
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	16
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	16
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P52480","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	16
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P11980","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	8
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	8
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P52480","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	16
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P52480","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	8
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	8
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P52480","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"21700219","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	16
Details	Modified residue: {"description":"4-hydroxyproline","evidences":[{"source":"PubMed","id":"21620138","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	16
Details	Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"30487609","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"24120661","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26787900","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P52480","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	24
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---