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9O12

Kv2.1 in an intermediate conformation with 2 voltage sensors down and an open pore

Functional Information from GO Data
ChainGOidnamespacecontents
A0000149molecular_functionSNARE binding
A0001508biological_processaction potential
A0005249molecular_functionvoltage-gated potassium channel activity
A0005251molecular_functiondelayed rectifier potassium channel activity
A0005267molecular_functionpotassium channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006813biological_processpotassium ion transport
A0006887biological_processexocytosis
A0006904biological_processvesicle docking involved in exocytosis
A0007215biological_processglutamate receptor signaling pathway
A0008076cellular_componentvoltage-gated potassium channel complex
A0009986cellular_componentcell surface
A0010701biological_processpositive regulation of norepinephrine secretion
A0015271molecular_functionoutward rectifier potassium channel activity
A0015459molecular_functionpotassium channel regulator activity
A0016020cellular_componentmembrane
A0016324cellular_componentapical plasma membrane
A0016328cellular_componentlateral plasma membrane
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0031669biological_processcellular response to nutrient levels
A0032590cellular_componentdendrite membrane
A0032809cellular_componentneuronal cell body membrane
A0033605biological_processpositive regulation of catecholamine secretion
A0034220biological_processmonoatomic ion transmembrane transport
A0034702cellular_componentmonoatomic ion channel complex
A0042383cellular_componentsarcolemma
A0042593biological_processglucose homeostasis
A0043005cellular_componentneuron projection
A0043025cellular_componentneuronal cell body
A0043204cellular_componentperikaryon
A0044325molecular_functiontransmembrane transporter binding
A0045163biological_processclustering of voltage-gated potassium channels
A0045202cellular_componentsynapse
A0045211cellular_componentpostsynaptic membrane
A0045956biological_processpositive regulation of calcium ion-dependent exocytosis
A0046676biological_processnegative regulation of insulin secretion
A0046982molecular_functionprotein heterodimerization activity
A0048471cellular_componentperinuclear region of cytoplasm
A0048678biological_processresponse to axon injury
A0071277biological_processcellular response to calcium ion
A0071333biological_processcellular response to glucose stimulus
A0071805biological_processpotassium ion transmembrane transport
A0072659biological_processprotein localization to plasma membrane
A0090314biological_processpositive regulation of protein targeting to membrane
A0097623biological_processpotassium ion export across plasma membrane
A0098900biological_processregulation of action potential
A0098981cellular_componentcholinergic synapse
A0099634cellular_componentpostsynaptic specialization membrane
A1900454biological_processpositive regulation of long-term synaptic depression
A1902065biological_processresponse to L-glutamate
A1990635cellular_componentproximal dendrite
A2000671biological_processregulation of motor neuron apoptotic process
B0000149molecular_functionSNARE binding
B0001508biological_processaction potential
B0005249molecular_functionvoltage-gated potassium channel activity
B0005251molecular_functiondelayed rectifier potassium channel activity
B0005267molecular_functionpotassium channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006813biological_processpotassium ion transport
B0006887biological_processexocytosis
B0006904biological_processvesicle docking involved in exocytosis
B0007215biological_processglutamate receptor signaling pathway
B0008076cellular_componentvoltage-gated potassium channel complex
B0009986cellular_componentcell surface
B0010701biological_processpositive regulation of norepinephrine secretion
B0015271molecular_functionoutward rectifier potassium channel activity
B0015459molecular_functionpotassium channel regulator activity
B0016020cellular_componentmembrane
B0016324cellular_componentapical plasma membrane
B0016328cellular_componentlateral plasma membrane
B0030424cellular_componentaxon
B0030425cellular_componentdendrite
B0031669biological_processcellular response to nutrient levels
B0032590cellular_componentdendrite membrane
B0032809cellular_componentneuronal cell body membrane
B0033605biological_processpositive regulation of catecholamine secretion
B0034220biological_processmonoatomic ion transmembrane transport
B0034702cellular_componentmonoatomic ion channel complex
B0042383cellular_componentsarcolemma
B0042593biological_processglucose homeostasis
B0043005cellular_componentneuron projection
B0043025cellular_componentneuronal cell body
B0043204cellular_componentperikaryon
B0044325molecular_functiontransmembrane transporter binding
B0045163biological_processclustering of voltage-gated potassium channels
B0045202cellular_componentsynapse
B0045211cellular_componentpostsynaptic membrane
B0045956biological_processpositive regulation of calcium ion-dependent exocytosis
B0046676biological_processnegative regulation of insulin secretion
B0046982molecular_functionprotein heterodimerization activity
B0048471cellular_componentperinuclear region of cytoplasm
B0048678biological_processresponse to axon injury
B0071277biological_processcellular response to calcium ion
B0071333biological_processcellular response to glucose stimulus
B0071805biological_processpotassium ion transmembrane transport
B0072659biological_processprotein localization to plasma membrane
B0090314biological_processpositive regulation of protein targeting to membrane
B0097623biological_processpotassium ion export across plasma membrane
B0098900biological_processregulation of action potential
B0098981cellular_componentcholinergic synapse
B0099634cellular_componentpostsynaptic specialization membrane
B1900454biological_processpositive regulation of long-term synaptic depression
B1902065biological_processresponse to L-glutamate
B1990635cellular_componentproximal dendrite
B2000671biological_processregulation of motor neuron apoptotic process
C0000149molecular_functionSNARE binding
C0001508biological_processaction potential
C0005249molecular_functionvoltage-gated potassium channel activity
C0005251molecular_functiondelayed rectifier potassium channel activity
C0005267molecular_functionpotassium channel activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006813biological_processpotassium ion transport
C0006887biological_processexocytosis
C0006904biological_processvesicle docking involved in exocytosis
C0007215biological_processglutamate receptor signaling pathway
C0008076cellular_componentvoltage-gated potassium channel complex
C0009986cellular_componentcell surface
C0010701biological_processpositive regulation of norepinephrine secretion
C0015271molecular_functionoutward rectifier potassium channel activity
C0015459molecular_functionpotassium channel regulator activity
C0016020cellular_componentmembrane
C0016324cellular_componentapical plasma membrane
C0016328cellular_componentlateral plasma membrane
C0030424cellular_componentaxon
C0030425cellular_componentdendrite
C0031669biological_processcellular response to nutrient levels
C0032590cellular_componentdendrite membrane
C0032809cellular_componentneuronal cell body membrane
C0033605biological_processpositive regulation of catecholamine secretion
C0034220biological_processmonoatomic ion transmembrane transport
C0034702cellular_componentmonoatomic ion channel complex
C0042383cellular_componentsarcolemma
C0042593biological_processglucose homeostasis
C0043005cellular_componentneuron projection
C0043025cellular_componentneuronal cell body
C0043204cellular_componentperikaryon
C0044325molecular_functiontransmembrane transporter binding
C0045163biological_processclustering of voltage-gated potassium channels
C0045202cellular_componentsynapse
C0045211cellular_componentpostsynaptic membrane
C0045956biological_processpositive regulation of calcium ion-dependent exocytosis
C0046676biological_processnegative regulation of insulin secretion
C0046982molecular_functionprotein heterodimerization activity
C0048471cellular_componentperinuclear region of cytoplasm
C0048678biological_processresponse to axon injury
C0071277biological_processcellular response to calcium ion
C0071333biological_processcellular response to glucose stimulus
C0071805biological_processpotassium ion transmembrane transport
C0072659biological_processprotein localization to plasma membrane
C0090314biological_processpositive regulation of protein targeting to membrane
C0097623biological_processpotassium ion export across plasma membrane
C0098900biological_processregulation of action potential
C0098981cellular_componentcholinergic synapse
C0099634cellular_componentpostsynaptic specialization membrane
C1900454biological_processpositive regulation of long-term synaptic depression
C1902065biological_processresponse to L-glutamate
C1990635cellular_componentproximal dendrite
C2000671biological_processregulation of motor neuron apoptotic process
D0000149molecular_functionSNARE binding
D0001508biological_processaction potential
D0005249molecular_functionvoltage-gated potassium channel activity
D0005251molecular_functiondelayed rectifier potassium channel activity
D0005267molecular_functionpotassium channel activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006813biological_processpotassium ion transport
D0006887biological_processexocytosis
D0006904biological_processvesicle docking involved in exocytosis
D0007215biological_processglutamate receptor signaling pathway
D0008076cellular_componentvoltage-gated potassium channel complex
D0009986cellular_componentcell surface
D0010701biological_processpositive regulation of norepinephrine secretion
D0015271molecular_functionoutward rectifier potassium channel activity
D0015459molecular_functionpotassium channel regulator activity
D0016020cellular_componentmembrane
D0016324cellular_componentapical plasma membrane
D0016328cellular_componentlateral plasma membrane
D0030424cellular_componentaxon
D0030425cellular_componentdendrite
D0031669biological_processcellular response to nutrient levels
D0032590cellular_componentdendrite membrane
D0032809cellular_componentneuronal cell body membrane
D0033605biological_processpositive regulation of catecholamine secretion
D0034220biological_processmonoatomic ion transmembrane transport
D0034702cellular_componentmonoatomic ion channel complex
D0042383cellular_componentsarcolemma
D0042593biological_processglucose homeostasis
D0043005cellular_componentneuron projection
D0043025cellular_componentneuronal cell body
D0043204cellular_componentperikaryon
D0044325molecular_functiontransmembrane transporter binding
D0045163biological_processclustering of voltage-gated potassium channels
D0045202cellular_componentsynapse
D0045211cellular_componentpostsynaptic membrane
D0045956biological_processpositive regulation of calcium ion-dependent exocytosis
D0046676biological_processnegative regulation of insulin secretion
D0046982molecular_functionprotein heterodimerization activity
D0048471cellular_componentperinuclear region of cytoplasm
D0048678biological_processresponse to axon injury
D0071277biological_processcellular response to calcium ion
D0071333biological_processcellular response to glucose stimulus
D0071805biological_processpotassium ion transmembrane transport
D0072659biological_processprotein localization to plasma membrane
D0090314biological_processpositive regulation of protein targeting to membrane
D0097623biological_processpotassium ion export across plasma membrane
D0098900biological_processregulation of action potential
D0098981cellular_componentcholinergic synapse
D0099634cellular_componentpostsynaptic specialization membrane
D1900454biological_processpositive regulation of long-term synaptic depression
D1902065biological_processresponse to L-glutamate
D1990635cellular_componentproximal dendrite
D2000671biological_processregulation of motor neuron apoptotic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues84
DetailsTransmembrane: {"description":"Helical; Name=Segment S1","evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues200
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues84
DetailsTransmembrane: {"description":"Helical; Name=Segment S2","evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues84
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=Segment S3","evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues84
DetailsTransmembrane: {"description":"Helical; Voltage-sensor; Name=Segment S4","evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=Segment S5","evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues44
DetailsIntramembrane: {"description":"Helical; Name=Pore helix","evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues28
DetailsIntramembrane: {"evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues112
DetailsTransmembrane: {"description":"Helical; Name=Segment S6","evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues20
DetailsMotif: {"description":"Selectivity filter","evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

243911

PDB entries from 2025-10-29

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