9O11
Kv2.1 with voltage sensor in the up conformation under low potassium
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2572 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:P63142 |
| Chain | Residue | Details |
| A | MET1-VAL186 | |
| C | SER251-LYS259 | |
| C | LEU317-GLU330 | |
| C | LYS421-ILE858 | |
| D | MET1-VAL186 | |
| D | SER251-LYS259 | |
| D | LEU317-GLU330 | |
| D | LYS421-ILE858 | |
| A | SER251-LYS259 | |
| A | LEU317-GLU330 | |
| A | LYS421-ILE858 | |
| B | MET1-VAL186 | |
| B | SER251-LYS259 | |
| B | LEU317-GLU330 | |
| B | LYS421-ILE858 | |
| C | MET1-VAL186 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 84 |
| Details | TRANSMEM: Helical; Name=Segment S1 => ECO:0000250|UniProtKB:P63142 |
| Chain | Residue | Details |
| A | ALA187-LEU208 | |
| B | ALA187-LEU208 | |
| C | ALA187-LEU208 | |
| D | ALA187-LEU208 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 200 |
| Details | TOPO_DOM: Extracellular => ECO:0000250|UniProtKB:P63142 |
| Chain | Residue | Details |
| A | ASN209-GLN228 | |
| C | GLU281-ARG294 | |
| C | ALA352-ILE364 | |
| C | PRO385-LYS391 | |
| D | ASN209-GLN228 | |
| D | GLU281-ARG294 | |
| D | ALA352-ILE364 | |
| D | PRO385-LYS391 | |
| A | GLU281-ARG294 | |
| A | ALA352-ILE364 | |
| A | PRO385-LYS391 | |
| B | ASN209-GLN228 | |
| B | GLU281-ARG294 | |
| B | ALA352-ILE364 | |
| B | PRO385-LYS391 | |
| C | ASN209-GLN228 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 84 |
| Details | TRANSMEM: Helical; Name=Segment S2 => ECO:0000250|UniProtKB:P63142 |
| Chain | Residue | Details |
| A | LEU229-SER250 | |
| B | LEU229-SER250 | |
| C | LEU229-SER250 | |
| D | LEU229-SER250 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Name=Segment S3 => ECO:0000250|UniProtKB:P63142 |
| Chain | Residue | Details |
| A | GLY260-THR280 | |
| B | GLY260-THR280 | |
| C | GLY260-THR280 | |
| D | GLY260-THR280 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 84 |
| Details | TRANSMEM: Helical; Voltage-sensor; Name=Segment S4 => ECO:0000250|UniProtKB:P63142 |
| Chain | Residue | Details |
| A | VAL295-GLY316 | |
| B | VAL295-GLY316 | |
| C | VAL295-GLY316 | |
| D | VAL295-GLY316 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Name=Segment S5 => ECO:0000250|UniProtKB:P63142 |
| Chain | Residue | Details |
| A | LEU331-PHE351 | |
| B | LEU331-PHE351 | |
| C | LEU331-PHE351 | |
| D | LEU331-PHE351 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 44 |
| Details | INTRAMEM: Helical; Name=Pore helix => ECO:0000250|UniProtKB:P63142 |
| Chain | Residue | Details |
| A | PRO365-THR376 | |
| B | PRO365-THR376 | |
| C | PRO365-THR376 | |
| D | PRO365-THR376 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 28 |
| Details | INTRAMEM: INTRAMEM => ECO:0000250|UniProtKB:P63142 |
| Chain | Residue | Details |
| A | THR377-TYR384 | |
| B | THR377-TYR384 | |
| C | THR377-TYR384 | |
| D | THR377-TYR384 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 112 |
| Details | TRANSMEM: Helical; Name=Segment S6 => ECO:0000250|UniProtKB:P63142 |
| Chain | Residue | Details |
| A | ILE392-TYR420 | |
| B | ILE392-TYR420 | |
| C | ILE392-TYR420 | |
| D | ILE392-TYR420 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 44 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P15387 |
| Chain | Residue | Details |
| A | SER15 | |
| A | SER772 | |
| A | SER800 | |
| B | SER15 | |
| B | SER484 | |
| B | SER496 | |
| B | SER503 | |
| B | SER519 | |
| B | SER541 | |
| B | SER567 | |
| B | SER590 | |
| A | SER484 | |
| B | SER720 | |
| B | SER772 | |
| B | SER800 | |
| C | SER15 | |
| C | SER484 | |
| C | SER496 | |
| C | SER503 | |
| C | SER519 | |
| C | SER541 | |
| C | SER567 | |
| A | SER496 | |
| C | SER590 | |
| C | SER720 | |
| C | SER772 | |
| C | SER800 | |
| D | SER15 | |
| D | SER484 | |
| D | SER496 | |
| D | SER503 | |
| D | SER519 | |
| D | SER541 | |
| A | SER503 | |
| D | SER567 | |
| D | SER590 | |
| D | SER720 | |
| D | SER772 | |
| D | SER800 | |
| A | SER519 | |
| A | SER541 | |
| A | SER567 | |
| A | SER590 | |
| A | SER720 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphotyrosine; by Src => ECO:0000250|UniProtKB:P15387 |
| Chain | Residue | Details |
| A | TYR128 | |
| B | TYR128 | |
| C | TYR128 | |
| D | TYR128 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q03717 |
| Chain | Residue | Details |
| A | SER444 | |
| A | SER457 | |
| B | SER444 | |
| B | SER457 | |
| C | SER444 | |
| C | SER457 | |
| D | SER444 | |
| D | SER457 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine; by CDK5; in vitro => ECO:0000250|UniProtKB:P15387 |
| Chain | Residue | Details |
| A | SER520 | |
| A | SER656 | |
| B | SER520 | |
| B | SER656 | |
| C | SER520 | |
| C | SER656 | |
| D | SER520 | |
| D | SER656 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000305|PubMed:33124732 |
| Chain | Residue | Details |
| A | SER593 | |
| B | SER593 | |
| C | SER593 | |
| D | SER593 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by CDK5 => ECO:0000250|UniProtKB:P15387 |
| Chain | Residue | Details |
| A | SER607 | |
| B | SER607 | |
| C | SER607 | |
| D | SER607 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by CDK5, MAPK14; in vitro => ECO:0000250|UniProtKB:P15387 |
| Chain | Residue | Details |
| A | SER805 | |
| B | SER805 | |
| C | SER805 | |
| D | SER805 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000250|UniProtKB:P15387 |
| Chain | Residue | Details |
| A | LYS474 | |
| B | LYS474 | |
| C | LYS474 | |
| D | LYS474 |
