9NWD

Human E3 ligase UBR4-KCMF1-calmodulin complex (N-terminal)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005516	molecular_function	calmodulin binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005768	cellular_component	endosome
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005886	cellular_component	plasma membrane
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
A	0006979	biological_process	response to oxidative stress
A	0007032	biological_process	endosome organization
A	0008270	molecular_function	zinc ion binding
A	0010498	biological_process	proteasomal protein catabolic process
A	0010508	biological_process	positive regulation of autophagy
A	0016020	cellular_component	membrane
A	0016567	biological_process	protein ubiquitination
A	0016740	molecular_function	transferase activity
A	0035579	cellular_component	specific granule membrane
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0044314	biological_process	protein K27-linked ubiquitination
A	0045717	biological_process	negative regulation of fatty acid biosynthetic process
A	0046872	molecular_function	metal ion binding
A	0061630	molecular_function	ubiquitin protein ligase activity
A	0070821	cellular_component	tertiary granule membrane
A	0070936	biological_process	protein K48-linked ubiquitination
A	0070979	biological_process	protein K11-linked ubiquitination
A	0071596	biological_process	ubiquitin-dependent protein catabolic process via the N-end rule pathway
A	0071629	biological_process	cytoplasm protein quality control by the ubiquitin-proteasome system
A	0101003	cellular_component	ficolin-1-rich granule membrane
A	0140455	biological_process	cytoplasm protein quality control
A	0140468	biological_process	HRI-mediated signaling
A	0141191	biological_process	negative regulation of HRI-mediated signaling
A	0141198	biological_process	protein branched polyubiquitination
A	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
B	0005515	molecular_function	protein binding
B	0005516	molecular_function	calmodulin binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005768	cellular_component	endosome
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005886	cellular_component	plasma membrane
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
B	0006979	biological_process	response to oxidative stress
B	0007032	biological_process	endosome organization
B	0008270	molecular_function	zinc ion binding
B	0010498	biological_process	proteasomal protein catabolic process
B	0010508	biological_process	positive regulation of autophagy
B	0016020	cellular_component	membrane
B	0016567	biological_process	protein ubiquitination
B	0016740	molecular_function	transferase activity
B	0035579	cellular_component	specific granule membrane
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0044314	biological_process	protein K27-linked ubiquitination
B	0045717	biological_process	negative regulation of fatty acid biosynthetic process
B	0046872	molecular_function	metal ion binding
B	0061630	molecular_function	ubiquitin protein ligase activity
B	0070821	cellular_component	tertiary granule membrane
B	0070936	biological_process	protein K48-linked ubiquitination
B	0070979	biological_process	protein K11-linked ubiquitination
B	0071596	biological_process	ubiquitin-dependent protein catabolic process via the N-end rule pathway
B	0071629	biological_process	cytoplasm protein quality control by the ubiquitin-proteasome system
B	0101003	cellular_component	ficolin-1-rich granule membrane
B	0140455	biological_process	cytoplasm protein quality control
B	0140468	biological_process	HRI-mediated signaling
B	0141191	biological_process	negative regulation of HRI-mediated signaling
B	0141198	biological_process	protein branched polyubiquitination
B	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity

Functional Information from PROSITE/UniProt

site_id	PS00028
Number of Residues	23
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cnkl.CtftItqkefmnqHwyhc.H

Chain	Residue	Details
A	CYS1658-HIS1680

---

site_id	PS00923
Number of Residues	10
Details	ASP_GLU_RACEMASE_1 Aspartate and glutamate racemases signature 1. AVqClNTSSK

Chain	Residue	Details
A	ALA2551-LYS2560

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"A2AN08","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q2TL32","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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