9NU3

Uromodulin filament lattice in the kinked arrangement from human urine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
B	0005509	molecular_function	calcium ion binding
C	0005509	molecular_function	calcium ion binding
D	0005509	molecular_function	calcium ion binding
E	0005509	molecular_function	calcium ion binding
F	0005509	molecular_function	calcium ion binding
G	0005509	molecular_function	calcium ion binding
H	0005509	molecular_function	calcium ion binding
I	0005509	molecular_function	calcium ion binding
J	0005509	molecular_function	calcium ion binding
K	0005509	molecular_function	calcium ion binding
L	0005509	molecular_function	calcium ion binding
M	0005509	molecular_function	calcium ion binding
N	0005509	molecular_function	calcium ion binding
O	0005509	molecular_function	calcium ion binding
P	0005509	molecular_function	calcium ion binding
Q	0005509	molecular_function	calcium ion binding
R	0005509	molecular_function	calcium ion binding

Functional Information from PROSITE/UniProt

site_id	PS00010
Number of Residues	12
Details	ASX_HYDROXYL Aspartic acid and asparagine hydroxylation site. CvNtpgsFsCvC

Chain	Residue	Details
C	CYS83-CYS94
C	CYS126-CYS137

---

site_id	PS00682
Number of Residues	41
Details	ZP_1 ZP domain signature. VgtmldggDlsrFaLlMtnCYaTPss..NaTdplkyfIIqdr.C

Chain	Residue	Details
C	VAL487-CYS527

---

site_id	PS01186
Number of Residues	14
Details	EGF_2 EGF-like domain signature 2. CtCqeGFtgdglt..C

Chain	Residue	Details
C	CYS50-CYS63
C	CYS92-CYS106
C	CYS135-CYS150

---

site_id	PS01187
Number of Residues	28
Details	EGF_CA Calcium-binding EGF-like domain signature. DlDECaipgahn.......Csanss..CvNtpgsFsC

Chain	Residue	Details
C	ASP65-CYS92
C	ASP108-CYS135

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	403
Details	Domain: {"description":"EGF-like 4","evidences":[{"source":"PubMed","id":"26811476","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"33196145","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35273390","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1140
Details	Region: {"description":"ZP-N","evidences":[{"source":"PubMed","id":"26811476","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"32815518","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"33196145","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35273390","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	276
Details	Region: {"description":"Flexible ZP-N/ZP-C linker; important for secretion and polymerization into filaments","evidences":[{"source":"PubMed","id":"26811476","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	132
Details	Region: {"description":"Internal hydrophobic patch (IHP)","evidences":[{"source":"PubMed","id":"26811476","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"32815518","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"33196145","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	13
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"22171320","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26811476","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32616672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35273390","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7PFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q3N","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	13
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (high mannose) asparagine","evidences":[{"source":"PubMed","id":"32616672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35273390","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7PFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q3N","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	14
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"22171320","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32616672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33196145","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35273390","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6TQK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6TQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PFP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	14
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"22171320","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32616672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32815518","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33196145","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35273390","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6TQK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6TQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZS5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZYA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PFP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	13
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (high mannose) asparagine; alternate","evidences":[{"source":"PubMed","id":"32616672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32815518","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33196145","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6TQK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6TQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZS5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZYA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PFP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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