9NNJ

Crystal structure of CYP46A1 with 3-chloro-N-[(3M)-3-(1,3-oxazol-5-yl)phenyl]-N-(propan-2-yl)benzene-1-sulfonamide (compound 2)

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004497	molecular_function	monooxygenase activity
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006629	biological_process	lipid metabolic process
A	0006699	biological_process	bile acid biosynthetic process
A	0006707	biological_process	cholesterol catabolic process
A	0006805	biological_process	xenobiotic metabolic process
A	0007399	biological_process	nervous system development
A	0008202	biological_process	steroid metabolic process
A	0008203	biological_process	cholesterol metabolic process
A	0008207	biological_process	C21-steroid hormone metabolic process
A	0008395	molecular_function	steroid hydroxylase activity
A	0016020	cellular_component	membrane
A	0016125	biological_process	sterol metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0020037	molecular_function	heme binding
A	0030425	cellular_component	dendrite
A	0033781	molecular_function	cholesterol 24-hydroxylase activity
A	0042448	biological_process	progesterone metabolic process
A	0042995	cellular_component	cell projection
A	0045202	cellular_component	synapse
A	0046872	molecular_function	metal ion binding
A	0050649	molecular_function	testosterone 6-beta-hydroxylase activity
A	0062184	molecular_function	testosterone 16-beta-hydroxylase activity
A	0065008	biological_process	regulation of biological quality
A	0098793	cellular_component	presynapse
A	0098794	cellular_component	postsynapse
A	1900271	biological_process	regulation of long-term synaptic potentiation
A	1903044	biological_process	protein localization to membrane raft

Functional Information from PROSITE/UniProt

site_id	PS00086
Number of Residues	10
Details	CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FSlGHRSCIG

Chain	Residue	Details
A	PHE430-GLY439

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"18621681","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20667828","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23288837","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Q9F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Q9G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MDR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MDT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MDV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ENH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FIA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4J14","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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