9NN2

Composite structure of HSV-1 helicase-primase in complex with a forked DNA and amenamevir

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004386	molecular_function	helicase activity
A	0005524	molecular_function	ATP binding
A	0006260	biological_process	DNA replication
A	0016787	molecular_function	hydrolase activity
A	0039686	biological_process	bidirectional double-stranded viral DNA replication
A	0042025	cellular_component	host cell nucleus
B	0006260	biological_process	DNA replication
B	0008270	molecular_function	zinc ion binding
B	0016740	molecular_function	transferase activity
B	0039686	biological_process	bidirectional double-stranded viral DNA replication
B	0042025	cellular_component	host cell nucleus
B	0046872	molecular_function	metal ion binding
C	0005515	molecular_function	protein binding
C	0006260	biological_process	DNA replication
C	0039686	biological_process	bidirectional double-stranded viral DNA replication
C	0042025	cellular_component	host cell nucleus

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04030","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	40
Details	Zinc finger: {"description":"CHC2-type","evidences":[{"source":"HAMAP-Rule","id":"MF_04011","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"8189507","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Site: {"description":"Essential for primase activity","evidences":[{"source":"HAMAP-Rule","id":"MF_04011","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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