9NIR
Human Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3) inhibitor complex
This is a non-PDB format compatible entry.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002276 | biological_process | basophil activation involved in immune response |
| A | 0004081 | molecular_function | bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity |
| A | 0004528 | molecular_function | phosphodiesterase I activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006220 | biological_process | pyrimidine nucleotide metabolic process |
| A | 0006796 | biological_process | phosphate-containing compound metabolic process |
| A | 0008253 | molecular_function | 5'-nucleotidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0009143 | biological_process | nucleoside triphosphate catabolic process |
| A | 0009897 | cellular_component | external side of plasma membrane |
| A | 0009986 | cellular_component | cell surface |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0016462 | molecular_function | pyrophosphatase activity |
| A | 0030505 | biological_process | inorganic diphosphate transport |
| A | 0033007 | biological_process | negative regulation of mast cell activation involved in immune response |
| A | 0034432 | molecular_function | bis(5'-adenosyl)-pentaphosphatase activity |
| A | 0036219 | molecular_function | GTP diphosphatase activity |
| A | 0036221 | molecular_function | UTP diphosphatase activity |
| A | 0046034 | biological_process | ATP metabolic process |
| A | 0047429 | molecular_function | nucleoside triphosphate diphosphatase activity |
| A | 0047693 | molecular_function | ATP diphosphatase activity |
| A | 0047710 | molecular_function | bis(5'-adenosyl)-triphosphatase activity |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0050728 | biological_process | negative regulation of inflammatory response |
| A | 0055062 | biological_process | phosphate ion homeostasis |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070667 | biological_process | negative regulation of mast cell proliferation |
| A | 0106177 | molecular_function | cyclic-GMP-AMP hydrolase activity |
| A | 0160049 | biological_process | negative regulation of cGAS/STING signaling pathway |
Functional Information from PROSITE/UniProt
| site_id | PS00524 |
| Number of Residues | 21 |
| Details | SMB_1 Somatomedin B domain (SMB) signature. CrCdvaCkdrgd.CCwDFedtC |
| Chain | Residue | Details |
| A | CYS69-CYS89 | |
| A | CYS113-CYS133 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 44 |
| Details | Domain: {"description":"SMB 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00350","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 385 |
| Details | Region: {"description":"Phosphodiesterase","evidences":[{"source":"PubMed","id":"29717535","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Motif: {"description":"Cell attachment site","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"29717535","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 11 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29717535","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C01","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6C02","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29717535","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6C02","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29717535","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C01","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 7 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"29717535","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C02","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"29717535","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C01","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"29717535","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
