9NHC
Cryo-EM structure of SIWI-piRNA-target(49-nt)-GTSF1-Maelstrom complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004521 | molecular_function | RNA endonuclease activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0030237 | biological_process | female sex determination |
| A | 0034584 | molecular_function | piRNA binding |
| A | 0034587 | biological_process | piRNA processing |
| A | 0140965 | biological_process | secondary piRNA processing |
| A | 0140991 | biological_process | piRNA-mediated gene silencing by mRNA destabilization |
| A | 1990923 | cellular_component | PET complex |
| F | 0005634 | cellular_component | nucleus |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0007140 | biological_process | male meiotic nuclear division |
| F | 0007283 | biological_process | spermatogenesis |
| F | 0034587 | biological_process | piRNA processing |
| F | 0043186 | cellular_component | P granule |
| F | 0043565 | molecular_function | sequence-specific DNA binding |
| F | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| F | 0060964 | biological_process | regulation of miRNA-mediated gene silencing |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 110 |
| Details | Domain: {"description":"PAZ","evidences":[{"source":"PROSITE-ProRule","id":"PRU00142","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 291 |
| Details | Domain: {"description":"Piwi","evidences":[{"source":"PROSITE-ProRule","id":"PRU00150","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 76 |
| Details | Region: {"description":"L1 region","evidences":[{"source":"PubMed","id":"27693359","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 99 |
| Details | Region: {"description":"L2 region","evidences":[{"source":"PubMed","id":"27693359","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 130 |
| Details | Region: {"description":"MID region","evidences":[{"source":"PubMed","id":"27693359","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"27693359","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5GUH","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27693359","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5GUH","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
