9NDJ

Cryo-EM structure of the endogenous ClpP1/ClpP2 heterocomplex from Pseudomonas aeruginosa bound to the AAA+ ClpX unfoldase.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005524	molecular_function	ATP binding
A	0006457	biological_process	protein folding
A	0009376	cellular_component	HslUV protease complex
A	0016887	molecular_function	ATP hydrolysis activity
A	0046872	molecular_function	metal ion binding
A	0051082	molecular_function	unfolded protein binding
A	0051301	biological_process	cell division
A	0051603	biological_process	proteolysis involved in protein catabolic process
B	0000166	molecular_function	nucleotide binding
B	0005524	molecular_function	ATP binding
B	0006457	biological_process	protein folding
B	0009376	cellular_component	HslUV protease complex
B	0016887	molecular_function	ATP hydrolysis activity
B	0046872	molecular_function	metal ion binding
B	0051082	molecular_function	unfolded protein binding
B	0051301	biological_process	cell division
B	0051603	biological_process	proteolysis involved in protein catabolic process
C	0000166	molecular_function	nucleotide binding
C	0005524	molecular_function	ATP binding
C	0006457	biological_process	protein folding
C	0009376	cellular_component	HslUV protease complex
C	0016887	molecular_function	ATP hydrolysis activity
C	0046872	molecular_function	metal ion binding
C	0051082	molecular_function	unfolded protein binding
C	0051301	biological_process	cell division
C	0051603	biological_process	proteolysis involved in protein catabolic process
D	0000166	molecular_function	nucleotide binding
D	0005524	molecular_function	ATP binding
D	0006457	biological_process	protein folding
D	0009376	cellular_component	HslUV protease complex
D	0016887	molecular_function	ATP hydrolysis activity
D	0046872	molecular_function	metal ion binding
D	0051082	molecular_function	unfolded protein binding
D	0051301	biological_process	cell division
D	0051603	biological_process	proteolysis involved in protein catabolic process
E	0000166	molecular_function	nucleotide binding
E	0005524	molecular_function	ATP binding
E	0006457	biological_process	protein folding
E	0009376	cellular_component	HslUV protease complex
E	0016887	molecular_function	ATP hydrolysis activity
E	0046872	molecular_function	metal ion binding
E	0051082	molecular_function	unfolded protein binding
E	0051301	biological_process	cell division
E	0051603	biological_process	proteolysis involved in protein catabolic process
F	0000166	molecular_function	nucleotide binding
F	0005524	molecular_function	ATP binding
F	0006457	biological_process	protein folding
F	0009376	cellular_component	HslUV protease complex
F	0016887	molecular_function	ATP hydrolysis activity
F	0046872	molecular_function	metal ion binding
F	0051082	molecular_function	unfolded protein binding
F	0051301	biological_process	cell division
F	0051603	biological_process	proteolysis involved in protein catabolic process
H	0004176	molecular_function	ATP-dependent peptidase activity
H	0004252	molecular_function	serine-type endopeptidase activity
H	0005737	cellular_component	cytoplasm
H	0006508	biological_process	proteolysis
H	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
H	0008233	molecular_function	peptidase activity
H	0008236	molecular_function	serine-type peptidase activity
H	0009368	cellular_component	endopeptidase Clp complex
H	0016787	molecular_function	hydrolase activity
H	0044010	biological_process	single-species biofilm formation
H	0044011	biological_process	single-species biofilm formation on inanimate substrate
H	0051117	molecular_function	ATPase binding
H	0071236	biological_process	cellular response to antibiotic
H	0071978	biological_process	bacterial-type flagellum-dependent swarming motility
I	0004176	molecular_function	ATP-dependent peptidase activity
I	0004252	molecular_function	serine-type endopeptidase activity
I	0005737	cellular_component	cytoplasm
I	0006508	biological_process	proteolysis
I	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
I	0008233	molecular_function	peptidase activity
I	0008236	molecular_function	serine-type peptidase activity
I	0009368	cellular_component	endopeptidase Clp complex
I	0016787	molecular_function	hydrolase activity
I	0044010	biological_process	single-species biofilm formation
I	0044011	biological_process	single-species biofilm formation on inanimate substrate
I	0051117	molecular_function	ATPase binding
I	0071236	biological_process	cellular response to antibiotic
I	0071978	biological_process	bacterial-type flagellum-dependent swarming motility
J	0004176	molecular_function	ATP-dependent peptidase activity
J	0004252	molecular_function	serine-type endopeptidase activity
J	0005737	cellular_component	cytoplasm
J	0006508	biological_process	proteolysis
J	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
J	0008233	molecular_function	peptidase activity
J	0008236	molecular_function	serine-type peptidase activity
J	0009368	cellular_component	endopeptidase Clp complex
J	0016787	molecular_function	hydrolase activity
J	0044010	biological_process	single-species biofilm formation
J	0044011	biological_process	single-species biofilm formation on inanimate substrate
J	0051117	molecular_function	ATPase binding
J	0071236	biological_process	cellular response to antibiotic
J	0071978	biological_process	bacterial-type flagellum-dependent swarming motility
K	0004176	molecular_function	ATP-dependent peptidase activity
K	0004252	molecular_function	serine-type endopeptidase activity
K	0005737	cellular_component	cytoplasm
K	0006508	biological_process	proteolysis
K	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
K	0008233	molecular_function	peptidase activity
K	0008236	molecular_function	serine-type peptidase activity
K	0009368	cellular_component	endopeptidase Clp complex
K	0016787	molecular_function	hydrolase activity
K	0044010	biological_process	single-species biofilm formation
K	0044011	biological_process	single-species biofilm formation on inanimate substrate
K	0051117	molecular_function	ATPase binding
K	0071236	biological_process	cellular response to antibiotic
K	0071978	biological_process	bacterial-type flagellum-dependent swarming motility
L	0004176	molecular_function	ATP-dependent peptidase activity
L	0004252	molecular_function	serine-type endopeptidase activity
L	0005737	cellular_component	cytoplasm
L	0006508	biological_process	proteolysis
L	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
L	0008233	molecular_function	peptidase activity
L	0008236	molecular_function	serine-type peptidase activity
L	0009368	cellular_component	endopeptidase Clp complex
L	0016787	molecular_function	hydrolase activity
L	0044010	biological_process	single-species biofilm formation
L	0044011	biological_process	single-species biofilm formation on inanimate substrate
L	0051117	molecular_function	ATPase binding
L	0071236	biological_process	cellular response to antibiotic
L	0071978	biological_process	bacterial-type flagellum-dependent swarming motility
M	0004176	molecular_function	ATP-dependent peptidase activity
M	0004252	molecular_function	serine-type endopeptidase activity
M	0005737	cellular_component	cytoplasm
M	0006508	biological_process	proteolysis
M	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
M	0008233	molecular_function	peptidase activity
M	0008236	molecular_function	serine-type peptidase activity
M	0009368	cellular_component	endopeptidase Clp complex
M	0016787	molecular_function	hydrolase activity
M	0044010	biological_process	single-species biofilm formation
M	0044011	biological_process	single-species biofilm formation on inanimate substrate
M	0051117	molecular_function	ATPase binding
M	0071236	biological_process	cellular response to antibiotic
M	0071978	biological_process	bacterial-type flagellum-dependent swarming motility
N	0004176	molecular_function	ATP-dependent peptidase activity
N	0004252	molecular_function	serine-type endopeptidase activity
N	0005737	cellular_component	cytoplasm
N	0006508	biological_process	proteolysis
N	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
N	0008233	molecular_function	peptidase activity
N	0008236	molecular_function	serine-type peptidase activity
N	0009368	cellular_component	endopeptidase Clp complex
N	0016787	molecular_function	hydrolase activity
N	0044010	biological_process	single-species biofilm formation
N	0044011	biological_process	single-species biofilm formation on inanimate substrate
N	0051117	molecular_function	ATPase binding
N	0071236	biological_process	cellular response to antibiotic
N	0071978	biological_process	bacterial-type flagellum-dependent swarming motility
P	0004176	molecular_function	ATP-dependent peptidase activity
P	0004252	molecular_function	serine-type endopeptidase activity
P	0005737	cellular_component	cytoplasm
P	0006508	biological_process	proteolysis
P	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
P	0008233	molecular_function	peptidase activity
P	0008236	molecular_function	serine-type peptidase activity
P	0009368	cellular_component	endopeptidase Clp complex
P	0016787	molecular_function	hydrolase activity
P	0051117	molecular_function	ATPase binding
Q	0004176	molecular_function	ATP-dependent peptidase activity
Q	0004252	molecular_function	serine-type endopeptidase activity
Q	0005737	cellular_component	cytoplasm
Q	0006508	biological_process	proteolysis
Q	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
Q	0008233	molecular_function	peptidase activity
Q	0008236	molecular_function	serine-type peptidase activity
Q	0009368	cellular_component	endopeptidase Clp complex
Q	0016787	molecular_function	hydrolase activity
Q	0051117	molecular_function	ATPase binding
R	0004176	molecular_function	ATP-dependent peptidase activity
R	0004252	molecular_function	serine-type endopeptidase activity
R	0005737	cellular_component	cytoplasm
R	0006508	biological_process	proteolysis
R	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
R	0008233	molecular_function	peptidase activity
R	0008236	molecular_function	serine-type peptidase activity
R	0009368	cellular_component	endopeptidase Clp complex
R	0016787	molecular_function	hydrolase activity
R	0051117	molecular_function	ATPase binding
S	0004176	molecular_function	ATP-dependent peptidase activity
S	0004252	molecular_function	serine-type endopeptidase activity
S	0005737	cellular_component	cytoplasm
S	0006508	biological_process	proteolysis
S	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
S	0008233	molecular_function	peptidase activity
S	0008236	molecular_function	serine-type peptidase activity
S	0009368	cellular_component	endopeptidase Clp complex
S	0016787	molecular_function	hydrolase activity
S	0051117	molecular_function	ATPase binding
T	0004176	molecular_function	ATP-dependent peptidase activity
T	0004252	molecular_function	serine-type endopeptidase activity
T	0005737	cellular_component	cytoplasm
T	0006508	biological_process	proteolysis
T	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
T	0008233	molecular_function	peptidase activity
T	0008236	molecular_function	serine-type peptidase activity
T	0009368	cellular_component	endopeptidase Clp complex
T	0016787	molecular_function	hydrolase activity
T	0051117	molecular_function	ATPase binding
U	0004176	molecular_function	ATP-dependent peptidase activity
U	0004252	molecular_function	serine-type endopeptidase activity
U	0005737	cellular_component	cytoplasm
U	0006508	biological_process	proteolysis
U	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
U	0008233	molecular_function	peptidase activity
U	0008236	molecular_function	serine-type peptidase activity
U	0009368	cellular_component	endopeptidase Clp complex
U	0016787	molecular_function	hydrolase activity
U	0051117	molecular_function	ATPase binding
V	0004176	molecular_function	ATP-dependent peptidase activity
V	0004252	molecular_function	serine-type endopeptidase activity
V	0005737	cellular_component	cytoplasm
V	0006508	biological_process	proteolysis
V	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
V	0008233	molecular_function	peptidase activity
V	0008236	molecular_function	serine-type peptidase activity
V	0009368	cellular_component	endopeptidase Clp complex
V	0016787	molecular_function	hydrolase activity
V	0051117	molecular_function	ATPase binding

Functional Information from PROSITE/UniProt

site_id	PS00381
Number of Residues	12
Details	CLP_PROTEASE_SER Endopeptidase Clp serine active site. TtcIGqACSMGA

Chain	Residue	Details
H	THR91-ALA102

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site_id	PS00382
Number of Residues	14
Details	CLP_PROTEASE_HIS Endopeptidase Clp histidine active site. RyslPntrFLLHQP

Chain	Residue	Details
P	ARG112-PRO125
H	ARG113-PRO126

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