9NDJ

Cryo-EM structure of the endogenous ClpP1/ClpP2 heterocomplex from Pseudomonas aeruginosa bound to the AAA+ ClpX unfoldase.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0006457	biological_process	protein folding
A	0008270	molecular_function	zinc ion binding
A	0009376	cellular_component	HslUV protease complex
A	0016887	molecular_function	ATP hydrolysis activity
A	0046983	molecular_function	protein dimerization activity
A	0051082	molecular_function	unfolded protein binding
A	0051301	biological_process	cell division
A	0140662	molecular_function	ATP-dependent protein folding chaperone
B	0005524	molecular_function	ATP binding
B	0006457	biological_process	protein folding
B	0008270	molecular_function	zinc ion binding
B	0009376	cellular_component	HslUV protease complex
B	0016887	molecular_function	ATP hydrolysis activity
B	0046983	molecular_function	protein dimerization activity
B	0051082	molecular_function	unfolded protein binding
B	0051301	biological_process	cell division
B	0140662	molecular_function	ATP-dependent protein folding chaperone
C	0005524	molecular_function	ATP binding
C	0006457	biological_process	protein folding
C	0008270	molecular_function	zinc ion binding
C	0009376	cellular_component	HslUV protease complex
C	0016887	molecular_function	ATP hydrolysis activity
C	0046983	molecular_function	protein dimerization activity
C	0051082	molecular_function	unfolded protein binding
C	0051301	biological_process	cell division
C	0140662	molecular_function	ATP-dependent protein folding chaperone
D	0005524	molecular_function	ATP binding
D	0006457	biological_process	protein folding
D	0008270	molecular_function	zinc ion binding
D	0009376	cellular_component	HslUV protease complex
D	0016887	molecular_function	ATP hydrolysis activity
D	0046983	molecular_function	protein dimerization activity
D	0051082	molecular_function	unfolded protein binding
D	0051301	biological_process	cell division
D	0140662	molecular_function	ATP-dependent protein folding chaperone
E	0005524	molecular_function	ATP binding
E	0006457	biological_process	protein folding
E	0008270	molecular_function	zinc ion binding
E	0009376	cellular_component	HslUV protease complex
E	0016887	molecular_function	ATP hydrolysis activity
E	0046983	molecular_function	protein dimerization activity
E	0051082	molecular_function	unfolded protein binding
E	0051301	biological_process	cell division
E	0140662	molecular_function	ATP-dependent protein folding chaperone
F	0005524	molecular_function	ATP binding
F	0006457	biological_process	protein folding
F	0008270	molecular_function	zinc ion binding
F	0009376	cellular_component	HslUV protease complex
F	0016887	molecular_function	ATP hydrolysis activity
F	0046983	molecular_function	protein dimerization activity
F	0051082	molecular_function	unfolded protein binding
F	0051301	biological_process	cell division
F	0140662	molecular_function	ATP-dependent protein folding chaperone
H	0004176	molecular_function	ATP-dependent peptidase activity
H	0004252	molecular_function	serine-type endopeptidase activity
H	0005737	cellular_component	cytoplasm
H	0006508	biological_process	proteolysis
H	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
H	0044010	biological_process	single-species biofilm formation
H	0044011	biological_process	single-species biofilm formation on inanimate substrate
H	0051117	molecular_function	ATPase binding
H	0071236	biological_process	cellular response to antibiotic
H	0071978	biological_process	bacterial-type flagellum-dependent swarming motility
I	0004176	molecular_function	ATP-dependent peptidase activity
I	0004252	molecular_function	serine-type endopeptidase activity
I	0005737	cellular_component	cytoplasm
I	0006508	biological_process	proteolysis
I	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
I	0044010	biological_process	single-species biofilm formation
I	0044011	biological_process	single-species biofilm formation on inanimate substrate
I	0051117	molecular_function	ATPase binding
I	0071236	biological_process	cellular response to antibiotic
I	0071978	biological_process	bacterial-type flagellum-dependent swarming motility
J	0004176	molecular_function	ATP-dependent peptidase activity
J	0004252	molecular_function	serine-type endopeptidase activity
J	0005737	cellular_component	cytoplasm
J	0006508	biological_process	proteolysis
J	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
J	0044010	biological_process	single-species biofilm formation
J	0044011	biological_process	single-species biofilm formation on inanimate substrate
J	0051117	molecular_function	ATPase binding
J	0071236	biological_process	cellular response to antibiotic
J	0071978	biological_process	bacterial-type flagellum-dependent swarming motility
K	0004176	molecular_function	ATP-dependent peptidase activity
K	0004252	molecular_function	serine-type endopeptidase activity
K	0005737	cellular_component	cytoplasm
K	0006508	biological_process	proteolysis
K	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
K	0044010	biological_process	single-species biofilm formation
K	0044011	biological_process	single-species biofilm formation on inanimate substrate
K	0051117	molecular_function	ATPase binding
K	0071236	biological_process	cellular response to antibiotic
K	0071978	biological_process	bacterial-type flagellum-dependent swarming motility
L	0004176	molecular_function	ATP-dependent peptidase activity
L	0004252	molecular_function	serine-type endopeptidase activity
L	0005737	cellular_component	cytoplasm
L	0006508	biological_process	proteolysis
L	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
L	0044010	biological_process	single-species biofilm formation
L	0044011	biological_process	single-species biofilm formation on inanimate substrate
L	0051117	molecular_function	ATPase binding
L	0071236	biological_process	cellular response to antibiotic
L	0071978	biological_process	bacterial-type flagellum-dependent swarming motility
M	0004176	molecular_function	ATP-dependent peptidase activity
M	0004252	molecular_function	serine-type endopeptidase activity
M	0005737	cellular_component	cytoplasm
M	0006508	biological_process	proteolysis
M	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
M	0044010	biological_process	single-species biofilm formation
M	0044011	biological_process	single-species biofilm formation on inanimate substrate
M	0051117	molecular_function	ATPase binding
M	0071236	biological_process	cellular response to antibiotic
M	0071978	biological_process	bacterial-type flagellum-dependent swarming motility
N	0004176	molecular_function	ATP-dependent peptidase activity
N	0004252	molecular_function	serine-type endopeptidase activity
N	0005737	cellular_component	cytoplasm
N	0006508	biological_process	proteolysis
N	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
N	0044010	biological_process	single-species biofilm formation
N	0044011	biological_process	single-species biofilm formation on inanimate substrate
N	0051117	molecular_function	ATPase binding
N	0071236	biological_process	cellular response to antibiotic
N	0071978	biological_process	bacterial-type flagellum-dependent swarming motility
P	0004176	molecular_function	ATP-dependent peptidase activity
P	0004252	molecular_function	serine-type endopeptidase activity
P	0005737	cellular_component	cytoplasm
P	0006508	biological_process	proteolysis
P	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
P	0051117	molecular_function	ATPase binding
Q	0004176	molecular_function	ATP-dependent peptidase activity
Q	0004252	molecular_function	serine-type endopeptidase activity
Q	0005737	cellular_component	cytoplasm
Q	0006508	biological_process	proteolysis
Q	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
Q	0051117	molecular_function	ATPase binding
R	0004176	molecular_function	ATP-dependent peptidase activity
R	0004252	molecular_function	serine-type endopeptidase activity
R	0005737	cellular_component	cytoplasm
R	0006508	biological_process	proteolysis
R	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
R	0051117	molecular_function	ATPase binding
S	0004176	molecular_function	ATP-dependent peptidase activity
S	0004252	molecular_function	serine-type endopeptidase activity
S	0005737	cellular_component	cytoplasm
S	0006508	biological_process	proteolysis
S	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
S	0051117	molecular_function	ATPase binding
T	0004176	molecular_function	ATP-dependent peptidase activity
T	0004252	molecular_function	serine-type endopeptidase activity
T	0005737	cellular_component	cytoplasm
T	0006508	biological_process	proteolysis
T	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
T	0051117	molecular_function	ATPase binding
U	0004176	molecular_function	ATP-dependent peptidase activity
U	0004252	molecular_function	serine-type endopeptidase activity
U	0005737	cellular_component	cytoplasm
U	0006508	biological_process	proteolysis
U	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
U	0051117	molecular_function	ATPase binding
V	0004176	molecular_function	ATP-dependent peptidase activity
V	0004252	molecular_function	serine-type endopeptidase activity
V	0005737	cellular_component	cytoplasm
V	0006508	biological_process	proteolysis
V	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
V	0051117	molecular_function	ATPase binding

Functional Information from PROSITE/UniProt

site_id	PS00381
Number of Residues	12
Details	CLP_PROTEASE_SER Endopeptidase Clp serine active site. TtcIGqACSMGA

Chain	Residue	Details
H	THR91-ALA102

---

site_id	PS00382
Number of Residues	14
Details	CLP_PROTEASE_HIS Endopeptidase Clp histidine active site. RyslPntrFLLHQP

Chain	Residue	Details
P	ARG112-PRO125
H	ARG113-PRO126

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	42
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00175","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	14
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_00444","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	14
Details	Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00444","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---