9N82

The ligation (AMP-Lys) complex in the NHEJ pathway

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000723	biological_process	telomere maintenance
A	0000725	biological_process	recombinational repair
A	0000781	cellular_component	chromosome, telomeric region
A	0000783	cellular_component	nuclear telomere cap complex
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0002218	biological_process	activation of innate immune response
A	0002376	biological_process	immune system process
A	0002684	biological_process	positive regulation of immune system process
A	0003677	molecular_function	DNA binding
A	0003678	molecular_function	DNA helicase activity
A	0003690	molecular_function	double-stranded DNA binding
A	0003691	molecular_function	double-stranded telomeric DNA binding
A	0003723	molecular_function	RNA binding
A	0003824	molecular_function	catalytic activity
A	0004386	molecular_function	helicase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005667	cellular_component	transcription regulator complex
A	0005694	cellular_component	chromosome
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
A	0006281	biological_process	DNA repair
A	0006303	biological_process	double-strand break repair via nonhomologous end joining
A	0006310	biological_process	DNA recombination
A	0006974	biological_process	DNA damage response
A	0008094	molecular_function	ATP-dependent activity, acting on DNA
A	0010212	biological_process	response to ionizing radiation
A	0010558	biological_process	negative regulation of macromolecule biosynthetic process
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0016829	molecular_function	lyase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0030332	molecular_function	cyclin binding
A	0032991	cellular_component	protein-containing complex
A	0032993	cellular_component	protein-DNA complex
A	0034774	cellular_component	secretory granule lumen
A	0042162	molecular_function	telomeric DNA binding
A	0043564	cellular_component	Ku70:Ku80 complex
A	0044877	molecular_function	protein-containing complex binding
A	0045027	molecular_function	DNA end binding
A	0045087	biological_process	innate immune response
A	0045621	biological_process	positive regulation of lymphocyte differentiation
A	0045860	biological_process	positive regulation of protein kinase activity
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0048660	biological_process	regulation of smooth muscle cell proliferation
A	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
A	0070418	cellular_component	DNA-dependent protein kinase complex
A	0070419	cellular_component	nonhomologous end joining complex
A	0071475	biological_process	cellular hyperosmotic salinity response
A	0071480	biological_process	cellular response to gamma radiation
A	0071481	biological_process	cellular response to X-ray
A	0097110	molecular_function	scaffold protein binding
A	0097680	biological_process	double-strand break repair via classical nonhomologous end joining
A	1904813	cellular_component	ficolin-1-rich granule lumen
B	0000166	molecular_function	nucleotide binding
B	0000723	biological_process	telomere maintenance
B	0000725	biological_process	recombinational repair
B	0000781	cellular_component	chromosome, telomeric region
B	0000783	cellular_component	nuclear telomere cap complex
B	0000976	molecular_function	transcription cis-regulatory region binding
B	0002218	biological_process	activation of innate immune response
B	0002376	biological_process	immune system process
B	0003677	molecular_function	DNA binding
B	0003678	molecular_function	DNA helicase activity
B	0003690	molecular_function	double-stranded DNA binding
B	0003691	molecular_function	double-stranded telomeric DNA binding
B	0003723	molecular_function	RNA binding
B	0004386	molecular_function	helicase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005694	cellular_component	chromosome
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
B	0006281	biological_process	DNA repair
B	0006302	biological_process	double-strand break repair
B	0006303	biological_process	double-strand break repair via nonhomologous end joining
B	0006310	biological_process	DNA recombination
B	0006974	biological_process	DNA damage response
B	0007004	biological_process	telomere maintenance via telomerase
B	0008047	molecular_function	enzyme activator activity
B	0008094	molecular_function	ATP-dependent activity, acting on DNA
B	0010558	biological_process	negative regulation of macromolecule biosynthetic process
B	0016020	cellular_component	membrane
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0022008	biological_process	neurogenesis
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0032040	cellular_component	small-subunit processome
B	0032204	biological_process	regulation of telomere maintenance
B	0032991	cellular_component	protein-containing complex
B	0032993	cellular_component	protein-DNA complex
B	0034462	biological_process	small-subunit processome assembly
B	0034511	molecular_function	U3 snoRNA binding
B	0034774	cellular_component	secretory granule lumen
B	0042162	molecular_function	telomeric DNA binding
B	0042254	biological_process	ribosome biogenesis
B	0043564	cellular_component	Ku70:Ku80 complex
B	0044877	molecular_function	protein-containing complex binding
B	0045027	molecular_function	DNA end binding
B	0045087	biological_process	innate immune response
B	0045860	biological_process	positive regulation of protein kinase activity
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0048660	biological_process	regulation of smooth muscle cell proliferation
B	0050769	biological_process	positive regulation of neurogenesis
B	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
B	0060218	biological_process	hematopoietic stem cell differentiation
B	0070198	biological_process	protein localization to chromosome, telomeric region
B	0070418	cellular_component	DNA-dependent protein kinase complex
B	0070419	cellular_component	nonhomologous end joining complex
B	0071425	biological_process	hematopoietic stem cell proliferation
B	0071480	biological_process	cellular response to gamma radiation
B	0090734	cellular_component	site of DNA damage
B	1904430	biological_process	negative regulation of t-circle formation
B	1990830	biological_process	cellular response to leukemia inhibitory factor
B	1990904	cellular_component	ribonucleoprotein complex
C	0000723	biological_process	telomere maintenance
C	0001650	cellular_component	fibrillar center
C	0003677	molecular_function	DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005694	cellular_component	chromosome
C	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
C	0006281	biological_process	DNA repair
C	0006303	biological_process	double-strand break repair via nonhomologous end joining
C	0006974	biological_process	DNA damage response
C	0007417	biological_process	central nervous system development
C	0010212	biological_process	response to ionizing radiation
C	0030183	biological_process	B cell differentiation
C	0030217	biological_process	T cell differentiation
C	0032807	cellular_component	DNA ligase IV complex
C	0033152	biological_process	immunoglobulin V(D)J recombination
C	0035861	cellular_component	site of double-strand break
C	0045027	molecular_function	DNA end binding
C	0051351	biological_process	positive regulation of ligase activity
C	0070182	molecular_function	DNA polymerase binding
C	0070419	cellular_component	nonhomologous end joining complex
D	0000793	cellular_component	condensed chromosome
D	0003677	molecular_function	DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005694	cellular_component	chromosome
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
D	0006281	biological_process	DNA repair
D	0006284	biological_process	base-excision repair
D	0006302	biological_process	double-strand break repair
D	0006303	biological_process	double-strand break repair via nonhomologous end joining
D	0006310	biological_process	DNA recombination
D	0006974	biological_process	DNA damage response
D	0010165	biological_process	response to X-ray
D	0016874	molecular_function	ligase activity
D	0019899	molecular_function	enzyme binding
D	0032807	cellular_component	DNA ligase IV complex
D	0033152	biological_process	immunoglobulin V(D)J recombination
D	0035861	cellular_component	site of double-strand break
D	0042802	molecular_function	identical protein binding
D	0051351	biological_process	positive regulation of ligase activity
D	0070419	cellular_component	nonhomologous end joining complex
D	0070975	molecular_function	FHA domain binding
D	0071285	biological_process	cellular response to lithium ion
D	1990166	biological_process	protein localization to site of double-strand break
E	0000793	cellular_component	condensed chromosome
E	0003677	molecular_function	DNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005694	cellular_component	chromosome
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
E	0006281	biological_process	DNA repair
E	0006284	biological_process	base-excision repair
E	0006302	biological_process	double-strand break repair
E	0006303	biological_process	double-strand break repair via nonhomologous end joining
E	0006310	biological_process	DNA recombination
E	0006974	biological_process	DNA damage response
E	0010165	biological_process	response to X-ray
E	0016874	molecular_function	ligase activity
E	0019899	molecular_function	enzyme binding
E	0032807	cellular_component	DNA ligase IV complex
E	0033152	biological_process	immunoglobulin V(D)J recombination
E	0035861	cellular_component	site of double-strand break
E	0042802	molecular_function	identical protein binding
E	0051351	biological_process	positive regulation of ligase activity
E	0070419	cellular_component	nonhomologous end joining complex
E	0070975	molecular_function	FHA domain binding
E	0071285	biological_process	cellular response to lithium ion
E	1990166	biological_process	protein localization to site of double-strand break
F	0000012	biological_process	single strand break repair
F	0000166	molecular_function	nucleotide binding
F	0000287	molecular_function	magnesium ion binding
F	0000781	cellular_component	chromosome, telomeric region
F	0000793	cellular_component	condensed chromosome
F	0001701	biological_process	in utero embryonic development
F	0002328	biological_process	pro-B cell differentiation
F	0003677	molecular_function	DNA binding
F	0003909	molecular_function	DNA ligase activity
F	0003910	molecular_function	DNA ligase (ATP) activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
F	0006281	biological_process	DNA repair
F	0006284	biological_process	base-excision repair
F	0006297	biological_process	nucleotide-excision repair, DNA gap filling
F	0006302	biological_process	double-strand break repair
F	0006303	biological_process	double-strand break repair via nonhomologous end joining
F	0006310	biological_process	DNA recombination
F	0006974	biological_process	DNA damage response
F	0007417	biological_process	central nervous system development
F	0008283	biological_process	cell population proliferation
F	0010165	biological_process	response to X-ray
F	0010212	biological_process	response to ionizing radiation
F	0010332	biological_process	response to gamma radiation
F	0016208	molecular_function	AMP binding
F	0016874	molecular_function	ligase activity
F	0022008	biological_process	neurogenesis
F	0032807	cellular_component	DNA ligase IV complex
F	0033077	biological_process	T cell differentiation in thymus
F	0033151	biological_process	V(D)J recombination
F	0033152	biological_process	immunoglobulin V(D)J recombination
F	0033153	biological_process	T cell receptor V(D)J recombination
F	0035019	biological_process	somatic stem cell population maintenance
F	0043524	biological_process	negative regulation of neuron apoptotic process
F	0045190	biological_process	isotype switching
F	0046872	molecular_function	metal ion binding
F	0048144	biological_process	fibroblast proliferation
F	0048146	biological_process	positive regulation of fibroblast proliferation
F	0050769	biological_process	positive regulation of neurogenesis
F	0051276	biological_process	chromosome organization
F	0051301	biological_process	cell division
F	0051402	biological_process	neuron apoptotic process
F	0070419	cellular_component	nonhomologous end joining complex
F	0071285	biological_process	cellular response to lithium ion
F	0071479	biological_process	cellular response to ionizing radiation
F	0072089	biological_process	stem cell proliferation
F	0075713	biological_process	establishment of integrated proviral latency
F	0097680	biological_process	double-strand break repair via classical nonhomologous end joining
F	1904155	biological_process	DN2 thymocyte differentiation
F	2001252	biological_process	positive regulation of chromosome organization
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005694	cellular_component	chromosome
G	0005737	cellular_component	cytoplasm
G	0006281	biological_process	DNA repair
G	0006303	biological_process	double-strand break repair via nonhomologous end joining
G	0006974	biological_process	DNA damage response
G	0035861	cellular_component	site of double-strand break
G	0042803	molecular_function	protein homodimerization activity
G	0043564	cellular_component	Ku70:Ku80 complex
G	0060090	molecular_function	molecular adaptor activity
G	0070182	molecular_function	DNA polymerase binding
G	0070419	cellular_component	nonhomologous end joining complex
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005694	cellular_component	chromosome
H	0005737	cellular_component	cytoplasm
H	0006281	biological_process	DNA repair
H	0006303	biological_process	double-strand break repair via nonhomologous end joining
H	0006974	biological_process	DNA damage response
H	0035861	cellular_component	site of double-strand break
H	0042803	molecular_function	protein homodimerization activity
H	0043564	cellular_component	Ku70:Ku80 complex
H	0060090	molecular_function	molecular adaptor activity
H	0070182	molecular_function	DNA polymerase binding
H	0070419	cellular_component	nonhomologous end joining complex
a	0000166	molecular_function	nucleotide binding
a	0000723	biological_process	telomere maintenance
a	0000725	biological_process	recombinational repair
a	0000781	cellular_component	chromosome, telomeric region
a	0000783	cellular_component	nuclear telomere cap complex
a	0000976	molecular_function	transcription cis-regulatory region binding
a	0002218	biological_process	activation of innate immune response
a	0002376	biological_process	immune system process
a	0002684	biological_process	positive regulation of immune system process
a	0003677	molecular_function	DNA binding
a	0003678	molecular_function	DNA helicase activity
a	0003690	molecular_function	double-stranded DNA binding
a	0003691	molecular_function	double-stranded telomeric DNA binding
a	0003723	molecular_function	RNA binding
a	0003824	molecular_function	catalytic activity
a	0004386	molecular_function	helicase activity
a	0005515	molecular_function	protein binding
a	0005524	molecular_function	ATP binding
a	0005576	cellular_component	extracellular region
a	0005634	cellular_component	nucleus
a	0005654	cellular_component	nucleoplasm
a	0005667	cellular_component	transcription regulator complex
a	0005694	cellular_component	chromosome
a	0005730	cellular_component	nucleolus
a	0005737	cellular_component	cytoplasm
a	0005829	cellular_component	cytosol
a	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
a	0006281	biological_process	DNA repair
a	0006303	biological_process	double-strand break repair via nonhomologous end joining
a	0006310	biological_process	DNA recombination
a	0006974	biological_process	DNA damage response
a	0008094	molecular_function	ATP-dependent activity, acting on DNA
a	0010212	biological_process	response to ionizing radiation
a	0010558	biological_process	negative regulation of macromolecule biosynthetic process
a	0016020	cellular_component	membrane
a	0016787	molecular_function	hydrolase activity
a	0016829	molecular_function	lyase activity
a	0016887	molecular_function	ATP hydrolysis activity
a	0030332	molecular_function	cyclin binding
a	0032991	cellular_component	protein-containing complex
a	0032993	cellular_component	protein-DNA complex
a	0034774	cellular_component	secretory granule lumen
a	0042162	molecular_function	telomeric DNA binding
a	0043564	cellular_component	Ku70:Ku80 complex
a	0044877	molecular_function	protein-containing complex binding
a	0045027	molecular_function	DNA end binding
a	0045087	biological_process	innate immune response
a	0045621	biological_process	positive regulation of lymphocyte differentiation
a	0045860	biological_process	positive regulation of protein kinase activity
a	0045892	biological_process	negative regulation of DNA-templated transcription
a	0045893	biological_process	positive regulation of DNA-templated transcription
a	0045944	biological_process	positive regulation of transcription by RNA polymerase II
a	0048660	biological_process	regulation of smooth muscle cell proliferation
a	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
a	0070418	cellular_component	DNA-dependent protein kinase complex
a	0070419	cellular_component	nonhomologous end joining complex
a	0071475	biological_process	cellular hyperosmotic salinity response
a	0071480	biological_process	cellular response to gamma radiation
a	0071481	biological_process	cellular response to X-ray
a	0097110	molecular_function	scaffold protein binding
a	0097680	biological_process	double-strand break repair via classical nonhomologous end joining
a	1904813	cellular_component	ficolin-1-rich granule lumen
b	0000166	molecular_function	nucleotide binding
b	0000723	biological_process	telomere maintenance
b	0000725	biological_process	recombinational repair
b	0000781	cellular_component	chromosome, telomeric region
b	0000783	cellular_component	nuclear telomere cap complex
b	0000976	molecular_function	transcription cis-regulatory region binding
b	0002218	biological_process	activation of innate immune response
b	0002376	biological_process	immune system process
b	0003677	molecular_function	DNA binding
b	0003678	molecular_function	DNA helicase activity
b	0003690	molecular_function	double-stranded DNA binding
b	0003691	molecular_function	double-stranded telomeric DNA binding
b	0003723	molecular_function	RNA binding
b	0004386	molecular_function	helicase activity
b	0005515	molecular_function	protein binding
b	0005524	molecular_function	ATP binding
b	0005576	cellular_component	extracellular region
b	0005634	cellular_component	nucleus
b	0005654	cellular_component	nucleoplasm
b	0005694	cellular_component	chromosome
b	0005730	cellular_component	nucleolus
b	0005737	cellular_component	cytoplasm
b	0005829	cellular_component	cytosol
b	0005886	cellular_component	plasma membrane
b	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
b	0006281	biological_process	DNA repair
b	0006302	biological_process	double-strand break repair
b	0006303	biological_process	double-strand break repair via nonhomologous end joining
b	0006310	biological_process	DNA recombination
b	0006974	biological_process	DNA damage response
b	0007004	biological_process	telomere maintenance via telomerase
b	0008047	molecular_function	enzyme activator activity
b	0008094	molecular_function	ATP-dependent activity, acting on DNA
b	0010558	biological_process	negative regulation of macromolecule biosynthetic process
b	0016020	cellular_component	membrane
b	0016787	molecular_function	hydrolase activity
b	0016887	molecular_function	ATP hydrolysis activity
b	0022008	biological_process	neurogenesis
b	0031625	molecular_function	ubiquitin protein ligase binding
b	0032040	cellular_component	small-subunit processome
b	0032204	biological_process	regulation of telomere maintenance
b	0032991	cellular_component	protein-containing complex
b	0032993	cellular_component	protein-DNA complex
b	0034462	biological_process	small-subunit processome assembly
b	0034511	molecular_function	U3 snoRNA binding
b	0034774	cellular_component	secretory granule lumen
b	0042162	molecular_function	telomeric DNA binding
b	0042254	biological_process	ribosome biogenesis
b	0043564	cellular_component	Ku70:Ku80 complex
b	0044877	molecular_function	protein-containing complex binding
b	0045027	molecular_function	DNA end binding
b	0045087	biological_process	innate immune response
b	0045860	biological_process	positive regulation of protein kinase activity
b	0045892	biological_process	negative regulation of DNA-templated transcription
b	0048660	biological_process	regulation of smooth muscle cell proliferation
b	0050769	biological_process	positive regulation of neurogenesis
b	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
b	0060218	biological_process	hematopoietic stem cell differentiation
b	0070198	biological_process	protein localization to chromosome, telomeric region
b	0070418	cellular_component	DNA-dependent protein kinase complex
b	0070419	cellular_component	nonhomologous end joining complex
b	0071425	biological_process	hematopoietic stem cell proliferation
b	0071480	biological_process	cellular response to gamma radiation
b	0090734	cellular_component	site of DNA damage
b	1904430	biological_process	negative regulation of t-circle formation
b	1990830	biological_process	cellular response to leukemia inhibitory factor
b	1990904	cellular_component	ribonucleoprotein complex
c	0000723	biological_process	telomere maintenance
c	0001650	cellular_component	fibrillar center
c	0003677	molecular_function	DNA binding
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0005654	cellular_component	nucleoplasm
c	0005694	cellular_component	chromosome
c	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
c	0006281	biological_process	DNA repair
c	0006303	biological_process	double-strand break repair via nonhomologous end joining
c	0006974	biological_process	DNA damage response
c	0007417	biological_process	central nervous system development
c	0010212	biological_process	response to ionizing radiation
c	0030183	biological_process	B cell differentiation
c	0030217	biological_process	T cell differentiation
c	0032807	cellular_component	DNA ligase IV complex
c	0033152	biological_process	immunoglobulin V(D)J recombination
c	0035861	cellular_component	site of double-strand break
c	0045027	molecular_function	DNA end binding
c	0051351	biological_process	positive regulation of ligase activity
c	0070182	molecular_function	DNA polymerase binding
c	0070419	cellular_component	nonhomologous end joining complex
d	0000793	cellular_component	condensed chromosome
d	0003677	molecular_function	DNA binding
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0005654	cellular_component	nucleoplasm
d	0005694	cellular_component	chromosome
d	0005737	cellular_component	cytoplasm
d	0005829	cellular_component	cytosol
d	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
d	0006281	biological_process	DNA repair
d	0006284	biological_process	base-excision repair
d	0006302	biological_process	double-strand break repair
d	0006303	biological_process	double-strand break repair via nonhomologous end joining
d	0006310	biological_process	DNA recombination
d	0006974	biological_process	DNA damage response
d	0010165	biological_process	response to X-ray
d	0016874	molecular_function	ligase activity
d	0019899	molecular_function	enzyme binding
d	0032807	cellular_component	DNA ligase IV complex
d	0033152	biological_process	immunoglobulin V(D)J recombination
d	0035861	cellular_component	site of double-strand break
d	0042802	molecular_function	identical protein binding
d	0051351	biological_process	positive regulation of ligase activity
d	0070419	cellular_component	nonhomologous end joining complex
d	0070975	molecular_function	FHA domain binding
d	0071285	biological_process	cellular response to lithium ion
d	1990166	biological_process	protein localization to site of double-strand break
e	0000793	cellular_component	condensed chromosome
e	0003677	molecular_function	DNA binding
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005654	cellular_component	nucleoplasm
e	0005694	cellular_component	chromosome
e	0005737	cellular_component	cytoplasm
e	0005829	cellular_component	cytosol
e	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
e	0006281	biological_process	DNA repair
e	0006284	biological_process	base-excision repair
e	0006302	biological_process	double-strand break repair
e	0006303	biological_process	double-strand break repair via nonhomologous end joining
e	0006310	biological_process	DNA recombination
e	0006974	biological_process	DNA damage response
e	0010165	biological_process	response to X-ray
e	0016874	molecular_function	ligase activity
e	0019899	molecular_function	enzyme binding
e	0032807	cellular_component	DNA ligase IV complex
e	0033152	biological_process	immunoglobulin V(D)J recombination
e	0035861	cellular_component	site of double-strand break
e	0042802	molecular_function	identical protein binding
e	0051351	biological_process	positive regulation of ligase activity
e	0070419	cellular_component	nonhomologous end joining complex
e	0070975	molecular_function	FHA domain binding
e	0071285	biological_process	cellular response to lithium ion
e	1990166	biological_process	protein localization to site of double-strand break
f	0000012	biological_process	single strand break repair
f	0000166	molecular_function	nucleotide binding
f	0000287	molecular_function	magnesium ion binding
f	0000781	cellular_component	chromosome, telomeric region
f	0000793	cellular_component	condensed chromosome
f	0001701	biological_process	in utero embryonic development
f	0002328	biological_process	pro-B cell differentiation
f	0003677	molecular_function	DNA binding
f	0003909	molecular_function	DNA ligase activity
f	0003910	molecular_function	DNA ligase (ATP) activity
f	0005515	molecular_function	protein binding
f	0005524	molecular_function	ATP binding
f	0005634	cellular_component	nucleus
f	0005654	cellular_component	nucleoplasm
f	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
f	0006281	biological_process	DNA repair
f	0006284	biological_process	base-excision repair
f	0006297	biological_process	nucleotide-excision repair, DNA gap filling
f	0006302	biological_process	double-strand break repair
f	0006303	biological_process	double-strand break repair via nonhomologous end joining
f	0006310	biological_process	DNA recombination
f	0006974	biological_process	DNA damage response
f	0007417	biological_process	central nervous system development
f	0008283	biological_process	cell population proliferation
f	0010165	biological_process	response to X-ray
f	0010212	biological_process	response to ionizing radiation
f	0010332	biological_process	response to gamma radiation
f	0016208	molecular_function	AMP binding
f	0016874	molecular_function	ligase activity
f	0022008	biological_process	neurogenesis
f	0032807	cellular_component	DNA ligase IV complex
f	0033077	biological_process	T cell differentiation in thymus
f	0033151	biological_process	V(D)J recombination
f	0033152	biological_process	immunoglobulin V(D)J recombination
f	0033153	biological_process	T cell receptor V(D)J recombination
f	0035019	biological_process	somatic stem cell population maintenance
f	0043524	biological_process	negative regulation of neuron apoptotic process
f	0045190	biological_process	isotype switching
f	0046872	molecular_function	metal ion binding
f	0048144	biological_process	fibroblast proliferation
f	0048146	biological_process	positive regulation of fibroblast proliferation
f	0050769	biological_process	positive regulation of neurogenesis
f	0051276	biological_process	chromosome organization
f	0051301	biological_process	cell division
f	0051402	biological_process	neuron apoptotic process
f	0070419	cellular_component	nonhomologous end joining complex
f	0071285	biological_process	cellular response to lithium ion
f	0071479	biological_process	cellular response to ionizing radiation
f	0072089	biological_process	stem cell proliferation
f	0075713	biological_process	establishment of integrated proviral latency
f	0097680	biological_process	double-strand break repair via classical nonhomologous end joining
f	1904155	biological_process	DN2 thymocyte differentiation
f	2001252	biological_process	positive regulation of chromosome organization

Functional Information from PROSITE/UniProt

site_id	PS00333
Number of Residues	25
Details	DNA_LIGASE_A2 ATP-dependent DNA ligase signature 2. EGIMVKqplsi...YKpdk...RgegwlKIK

Chain	Residue	Details
F	GLU427-LYS451

---

site_id	PS00697
Number of Residues	9
Details	DNA_LIGASE_A1 ATP-dependent DNA ligase AMP-binding site. ETKLDGERM

Chain	Residue	Details
F	GLU271-MET279

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000305|PubMed:27705800

Chain	Residue	Details
G	SER134
b	LYS665
H	SER134
d	ASP265
e	ASP265
B	LYS665
b	LYS144
b	LYS265
b	LYS332
b	LYS660

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000305|PubMed:27705800

Chain	Residue	Details
G	THR145
H	THR145
d	SER53
e	SER53
c	SER132
c	SER203
c	SER245
c	SER251

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000305|PubMed:27705800, ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
G	SER148
f	LYS451
H	SER148
F	LEU274
F	LYS449
F	LYS451
f	THR272
f	LYS273
f	LEU274
f	LYS449

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000305|PubMed:27705800, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
G	SER152
H	SER152
F	PHE367
F	LYS432
f	ARG278
f	LYS345
f	PHE367
f	LYS432

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255

Chain	Residue	Details
F	GLU331
F	GLU427
f	GLU331
f	GLU427

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by CK2 => ECO:0000269|PubMed:15385968, ECO:0000269|PubMed:20852255, ECO:0000269|PubMed:28453785, ECO:0007744|PubMed:24275569

Chain	Residue	Details
D	THR233
a	LYS544
a	LYS553
a	LYS556
E	THR233
d	THR233
e	THR233
A	LYS553
A	LYS556
a	LYS317
a	LYS539
a	LYS542

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
D	SER237
E	SER237
d	SER237
e	SER237

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
D	SER256
b	LYS532
b	LYS534
b	LYS566
b	LYS669
b	LYS688
E	SER256
d	SER256
e	SER256
B	LYS566
B	LYS669
B	LYS688
b	LYS195

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PRKDC => ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:28500754, ECO:0000269|PubMed:30247612, ECO:0007744|PubMed:23186163

Chain	Residue	Details
D	SER260
E	SER260
d	SER260
e	SER260

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PRKDC => ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:22228831

Chain	Residue	Details
D	SER303
E	SER303
d	SER303
e	SER303

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PRKDC => ECO:0000269|PubMed:28500754, ECO:0007744|PubMed:23186163

Chain	Residue	Details
D	SER304
E	SER304
d	SER304
e	SER304

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PRKDC => ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28500754, ECO:0007744|PubMed:23186163

Chain	Residue	Details
D	SER320
E	SER320
d	SER320
e	SER320

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by PRKDC => ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:28500754

Chain	Residue	Details
D	THR323
E	THR323
d	THR323
e	THR323

---

site_id	SWS_FT_FI14
Number of Residues	8
Details	MOD_RES: Phosphoserine; by PRKDC => ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:28500754, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332

Chain	Residue	Details
D	SER327
D	SER328
E	SER327
E	SER328
d	SER327
d	SER328
e	SER327
e	SER328

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:16478998

Chain	Residue	Details
D	LYS210
E	LYS210
d	LYS210
e	LYS210

---

site_id	SWS_FT_FI16
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:26774286

Chain	Residue	Details
D	LYS296
E	LYS296
d	LYS296
e	LYS296

---