9N1Y
BSEP E297G Apo Structure in GDN
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005768 | cellular_component | endosome |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0006699 | biological_process | bile acid biosynthetic process |
| A | 0006805 | biological_process | xenobiotic metabolic process |
| A | 0006855 | biological_process | xenobiotic transmembrane transport |
| A | 0006869 | biological_process | lipid transport |
| A | 0008206 | biological_process | bile acid metabolic process |
| A | 0008559 | molecular_function | ABC-type xenobiotic transporter activity |
| A | 0009986 | cellular_component | cell surface |
| A | 0015125 | molecular_function | bile acid transmembrane transporter activity |
| A | 0015126 | molecular_function | canalicular bile acid transmembrane transporter activity |
| A | 0015432 | molecular_function | ABC-type bile acid transporter activity |
| A | 0015721 | biological_process | bile acid and bile salt transport |
| A | 0015722 | biological_process | canalicular bile acid transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0016567 | biological_process | protein ubiquitination |
| A | 0031998 | biological_process | regulation of fatty acid beta-oxidation |
| A | 0042632 | biological_process | cholesterol homeostasis |
| A | 0045177 | cellular_component | apical part of cell |
| A | 0046581 | cellular_component | intercellular canaliculus |
| A | 0046618 | biological_process | xenobiotic export from cell |
| A | 0046691 | cellular_component | intracellular canaliculus |
| A | 0055037 | cellular_component | recycling endosome |
| A | 0055038 | cellular_component | recycling endosome membrane |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0055088 | biological_process | lipid homeostasis |
| A | 0055091 | biological_process | phospholipid homeostasis |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0120189 | biological_process | positive regulation of bile acid secretion |
| A | 1904251 | biological_process | regulation of bile acid metabolic process |
Functional Information from PROSITE/UniProt
| site_id | PS00211 |
| Number of Residues | 15 |
| Details | ABC_TRANSPORTER_1 ABC transporters family signature. MSGGQKQRVAIARAL |
| Chain | Residue | Details |
| A | MET559-LEU573 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 240 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 105 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 223 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 323 |
| Details | Domain: {"description":"ABC transmembrane type-1 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 236 |
| Details | Domain: {"description":"ABC transporter 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 288 |
| Details | Domain: {"description":"ABC transmembrane type-1 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | Region: {"description":"Mediates internalization from the plasma membrane","evidences":[{"source":"PubMed","id":"22262466","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9QY30","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"O70127","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"17082223","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
