9MXZ

Lecithin:Cholesterol Acyltransferase Bound to Apolipoprotein A-I dimer in HDL

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001540	molecular_function	amyloid-beta binding
A	0001935	biological_process	endothelial cell proliferation
A	0002719	biological_process	negative regulation of cytokine production involved in immune response
A	0005102	molecular_function	signaling receptor binding
A	0005319	molecular_function	lipid transporter activity
A	0005515	molecular_function	protein binding
A	0005543	molecular_function	phospholipid binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005769	cellular_component	early endosome
A	0005788	cellular_component	endoplasmic reticulum lumen
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006629	biological_process	lipid metabolic process
A	0006644	biological_process	phospholipid metabolic process
A	0006656	biological_process	phosphatidylcholine biosynthetic process
A	0006695	biological_process	cholesterol biosynthetic process
A	0006869	biological_process	lipid transport
A	0007179	biological_process	transforming growth factor beta receptor signaling pathway
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0007229	biological_process	integrin-mediated signaling pathway
A	0008035	molecular_function	high-density lipoprotein particle binding
A	0008202	biological_process	steroid metabolic process
A	0008203	biological_process	cholesterol metabolic process
A	0008211	biological_process	glucocorticoid metabolic process
A	0008289	molecular_function	lipid binding
A	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
A	0010875	biological_process	positive regulation of cholesterol efflux
A	0010903	biological_process	negative regulation of very-low-density lipoprotein particle remodeling
A	0015485	molecular_function	cholesterol binding
A	0018158	biological_process	protein oxidation
A	0018206	biological_process	peptidyl-methionine modification
A	0019899	molecular_function	enzyme binding
A	0019915	biological_process	lipid storage
A	0030139	cellular_component	endocytic vesicle
A	0030300	biological_process	regulation of intestinal cholesterol absorption
A	0030301	biological_process	cholesterol transport
A	0030325	biological_process	adrenal gland development
A	0031072	molecular_function	heat shock protein binding
A	0031410	cellular_component	cytoplasmic vesicle
A	0032489	biological_process	regulation of Cdc42 protein signal transduction
A	0032691	biological_process	negative regulation of interleukin-1 beta production
A	0033344	biological_process	cholesterol efflux
A	0033700	biological_process	phospholipid efflux
A	0034115	biological_process	negative regulation of heterotypic cell-cell adhesion
A	0034190	molecular_function	apolipoprotein receptor binding
A	0034191	molecular_function	apolipoprotein A-I receptor binding
A	0034205	biological_process	amyloid-beta formation
A	0034361	cellular_component	very-low-density lipoprotein particle
A	0034362	cellular_component	low-density lipoprotein particle
A	0034364	cellular_component	high-density lipoprotein particle
A	0034366	cellular_component	spherical high-density lipoprotein particle
A	0034375	biological_process	high-density lipoprotein particle remodeling
A	0034380	biological_process	high-density lipoprotein particle assembly
A	0034384	biological_process	high-density lipoprotein particle clearance
A	0034774	cellular_component	secretory granule lumen
A	0035025	biological_process	positive regulation of Rho protein signal transduction
A	0042158	biological_process	lipoprotein biosynthetic process
A	0042627	cellular_component	chylomicron
A	0042632	biological_process	cholesterol homeostasis
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0043534	biological_process	blood vessel endothelial cell migration
A	0043691	biological_process	reverse cholesterol transport
A	0045499	molecular_function	chemorepellent activity
A	0048018	molecular_function	receptor ligand activity
A	0050728	biological_process	negative regulation of inflammatory response
A	0050766	biological_process	positive regulation of phagocytosis
A	0050821	biological_process	protein stabilization
A	0050919	biological_process	negative chemotaxis
A	0051180	biological_process	vitamin transport
A	0051496	biological_process	positive regulation of stress fiber assembly
A	0055090	biological_process	acylglycerol homeostasis
A	0055091	biological_process	phospholipid homeostasis
A	0060228	molecular_function	phosphatidylcholine-sterol O-acyltransferase activator activity
A	0060354	biological_process	negative regulation of cell adhesion molecule production
A	0060761	biological_process	negative regulation of response to cytokine stimulus
A	0070062	cellular_component	extracellular exosome
A	0070328	biological_process	triglyceride homeostasis
A	0070371	biological_process	ERK1 and ERK2 cascade
A	0070508	biological_process	cholesterol import
A	0070653	molecular_function	high-density lipoprotein particle receptor binding
A	0071402	biological_process	cellular response to lipoprotein particle stimulus
A	0071682	cellular_component	endocytic vesicle lumen
A	0071813	molecular_function	lipoprotein particle binding
A	0072562	cellular_component	blood microparticle
A	0090205	biological_process	positive regulation of cholesterol metabolic process
A	0120020	molecular_function	cholesterol transfer activity
A	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
A	1902995	biological_process	positive regulation of phospholipid efflux
A	1903561	cellular_component	extracellular vesicle
A	1904646	biological_process	cellular response to amyloid-beta
B	0003847	molecular_function	1-alkyl-2-acetylglycerophosphocholine esterase activity
B	0004607	molecular_function	phosphatidylcholine-sterol O-acyltransferase activity
B	0004623	molecular_function	phospholipase A2 activity
B	0004771	molecular_function	sterol ester esterase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0006629	biological_process	lipid metabolic process
B	0006644	biological_process	phospholipid metabolic process
B	0006656	biological_process	phosphatidylcholine biosynthetic process
B	0008202	biological_process	steroid metabolic process
B	0008203	biological_process	cholesterol metabolic process
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0016787	molecular_function	hydrolase activity
B	0030301	biological_process	cholesterol transport
B	0034186	molecular_function	apolipoprotein A-I binding
B	0034364	cellular_component	high-density lipoprotein particle
B	0034372	biological_process	very-low-density lipoprotein particle remodeling
B	0034375	biological_process	high-density lipoprotein particle remodeling
B	0034435	biological_process	obsolete cholesterol esterification
B	0042157	biological_process	lipoprotein metabolic process
B	0042158	biological_process	lipoprotein biosynthetic process
B	0042632	biological_process	cholesterol homeostasis
B	0043691	biological_process	reverse cholesterol transport
B	0046222	biological_process	aflatoxin metabolic process
B	0046470	biological_process	phosphatidylcholine metabolic process
B	0046688	biological_process	response to copper ion
B	0047179	molecular_function	platelet-activating factor acetyltransferase activity
B	0051384	biological_process	response to glucocorticoid
B	0070062	cellular_component	extracellular exosome
B	0090107	biological_process	regulation of high-density lipoprotein particle assembly
C	0003847	molecular_function	1-alkyl-2-acetylglycerophosphocholine esterase activity
C	0004607	molecular_function	phosphatidylcholine-sterol O-acyltransferase activity
C	0004623	molecular_function	phospholipase A2 activity
C	0004771	molecular_function	sterol ester esterase activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0006629	biological_process	lipid metabolic process
C	0006644	biological_process	phospholipid metabolic process
C	0006656	biological_process	phosphatidylcholine biosynthetic process
C	0008202	biological_process	steroid metabolic process
C	0008203	biological_process	cholesterol metabolic process
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0016787	molecular_function	hydrolase activity
C	0030301	biological_process	cholesterol transport
C	0034186	molecular_function	apolipoprotein A-I binding
C	0034364	cellular_component	high-density lipoprotein particle
C	0034372	biological_process	very-low-density lipoprotein particle remodeling
C	0034375	biological_process	high-density lipoprotein particle remodeling
C	0034435	biological_process	obsolete cholesterol esterification
C	0042157	biological_process	lipoprotein metabolic process
C	0042158	biological_process	lipoprotein biosynthetic process
C	0042632	biological_process	cholesterol homeostasis
C	0043691	biological_process	reverse cholesterol transport
C	0046222	biological_process	aflatoxin metabolic process
C	0046470	biological_process	phosphatidylcholine metabolic process
C	0046688	biological_process	response to copper ion
C	0047179	molecular_function	platelet-activating factor acetyltransferase activity
C	0051384	biological_process	response to glucocorticoid
C	0070062	cellular_component	extracellular exosome
C	0090107	biological_process	regulation of high-density lipoprotein particle assembly
E	0001540	molecular_function	amyloid-beta binding
E	0001935	biological_process	endothelial cell proliferation
E	0002719	biological_process	negative regulation of cytokine production involved in immune response
E	0005102	molecular_function	signaling receptor binding
E	0005319	molecular_function	lipid transporter activity
E	0005515	molecular_function	protein binding
E	0005543	molecular_function	phospholipid binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005769	cellular_component	early endosome
E	0005788	cellular_component	endoplasmic reticulum lumen
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0006629	biological_process	lipid metabolic process
E	0006644	biological_process	phospholipid metabolic process
E	0006656	biological_process	phosphatidylcholine biosynthetic process
E	0006695	biological_process	cholesterol biosynthetic process
E	0006869	biological_process	lipid transport
E	0007179	biological_process	transforming growth factor beta receptor signaling pathway
E	0007186	biological_process	G protein-coupled receptor signaling pathway
E	0007229	biological_process	integrin-mediated signaling pathway
E	0008035	molecular_function	high-density lipoprotein particle binding
E	0008202	biological_process	steroid metabolic process
E	0008203	biological_process	cholesterol metabolic process
E	0008211	biological_process	glucocorticoid metabolic process
E	0008289	molecular_function	lipid binding
E	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
E	0010875	biological_process	positive regulation of cholesterol efflux
E	0010903	biological_process	negative regulation of very-low-density lipoprotein particle remodeling
E	0015485	molecular_function	cholesterol binding
E	0018158	biological_process	protein oxidation
E	0018206	biological_process	peptidyl-methionine modification
E	0019899	molecular_function	enzyme binding
E	0019915	biological_process	lipid storage
E	0030139	cellular_component	endocytic vesicle
E	0030300	biological_process	regulation of intestinal cholesterol absorption
E	0030301	biological_process	cholesterol transport
E	0030325	biological_process	adrenal gland development
E	0031072	molecular_function	heat shock protein binding
E	0031410	cellular_component	cytoplasmic vesicle
E	0032489	biological_process	regulation of Cdc42 protein signal transduction
E	0032691	biological_process	negative regulation of interleukin-1 beta production
E	0033344	biological_process	cholesterol efflux
E	0033700	biological_process	phospholipid efflux
E	0034115	biological_process	negative regulation of heterotypic cell-cell adhesion
E	0034190	molecular_function	apolipoprotein receptor binding
E	0034191	molecular_function	apolipoprotein A-I receptor binding
E	0034205	biological_process	amyloid-beta formation
E	0034361	cellular_component	very-low-density lipoprotein particle
E	0034362	cellular_component	low-density lipoprotein particle
E	0034364	cellular_component	high-density lipoprotein particle
E	0034366	cellular_component	spherical high-density lipoprotein particle
E	0034375	biological_process	high-density lipoprotein particle remodeling
E	0034380	biological_process	high-density lipoprotein particle assembly
E	0034384	biological_process	high-density lipoprotein particle clearance
E	0034774	cellular_component	secretory granule lumen
E	0035025	biological_process	positive regulation of Rho protein signal transduction
E	0042158	biological_process	lipoprotein biosynthetic process
E	0042627	cellular_component	chylomicron
E	0042632	biological_process	cholesterol homeostasis
E	0042802	molecular_function	identical protein binding
E	0042803	molecular_function	protein homodimerization activity
E	0043534	biological_process	blood vessel endothelial cell migration
E	0043691	biological_process	reverse cholesterol transport
E	0045499	molecular_function	chemorepellent activity
E	0048018	molecular_function	receptor ligand activity
E	0050728	biological_process	negative regulation of inflammatory response
E	0050766	biological_process	positive regulation of phagocytosis
E	0050821	biological_process	protein stabilization
E	0050919	biological_process	negative chemotaxis
E	0051180	biological_process	vitamin transport
E	0051496	biological_process	positive regulation of stress fiber assembly
E	0055090	biological_process	acylglycerol homeostasis
E	0055091	biological_process	phospholipid homeostasis
E	0060228	molecular_function	phosphatidylcholine-sterol O-acyltransferase activator activity
E	0060354	biological_process	negative regulation of cell adhesion molecule production
E	0060761	biological_process	negative regulation of response to cytokine stimulus
E	0070062	cellular_component	extracellular exosome
E	0070328	biological_process	triglyceride homeostasis
E	0070371	biological_process	ERK1 and ERK2 cascade
E	0070508	biological_process	cholesterol import
E	0070653	molecular_function	high-density lipoprotein particle receptor binding
E	0071402	biological_process	cellular response to lipoprotein particle stimulus
E	0071682	cellular_component	endocytic vesicle lumen
E	0071813	molecular_function	lipoprotein particle binding
E	0072562	cellular_component	blood microparticle
E	0090205	biological_process	positive regulation of cholesterol metabolic process
E	0120020	molecular_function	cholesterol transfer activity
E	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
E	1902995	biological_process	positive regulation of phospholipid efflux
E	1903561	cellular_component	extracellular vesicle
E	1904646	biological_process	cellular response to amyloid-beta

Functional Information from PROSITE/UniProt

site_id	PS00120
Number of Residues	10
Details	LIPASE_SER Lipases, serine active site. VFLIGHSLGC

Chain	Residue	Details
B	VAL175-CYS184

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	42
Details	Repeat: {"description":"1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	42
Details	Repeat: {"description":"2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	Repeat: {"description":"3; half-length"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	42
Details	Repeat: {"description":"4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	42
Details	Repeat: {"description":"5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	42
Details	Repeat: {"description":"6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	42
Details	Repeat: {"description":"7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	42
Details	Repeat: {"description":"8"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	20
Details	Repeat: {"description":"9; half-length"}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	46
Details	Repeat: {"description":"10"}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	398
Details	Region: {"description":"10 X approximate tandem repeats"}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	Modified residue: {"description":"Methionine sulfoxide","evidences":[{"source":"PubMed","id":"12576517","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) lysine","evidences":[{"source":"PubMed","id":"8261628","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"26195816","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"26195816","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	Site: {"description":"Determinant for substrate specificity","evidences":[{"source":"PubMed","id":"14636062","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"26195816","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7613477","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4X96","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26195816","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7613477","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4X96","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---