9MXT

Cryo-EM Structure of HIV-1 Reverse Transcriptase p66 tetramer in Complex with 5-{2-[2-(2-oxo-4-sulfanylidene-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}naphthalene-2-carbonitrile (JLJ648), a Non-nucleoside Inhibitor

This is a non-PDB format compatible entry.

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	190
Details	Domain: {"description":"Reverse transcriptase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00405","evidenceCode":"ECO:0000255"}]}

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site_id	SWS_FT_FI2
Number of Residues	16
Details	Region: {"description":"RT 'primer grip'"}

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site_id	SWS_FT_FI3
Number of Residues	64
Details	Motif: {"description":"Tryptophan repeat motif"}

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site_id	SWS_FT_FI4
Number of Residues	12
Details	Binding site: {}

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site_id	SWS_FT_FI5
Number of Residues	3
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

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site_id	SWS_FT_FI6
Number of Residues	8
Details	Site: {"description":"Essential for RT p66/p51 heterodimerization"}

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site_id	SWS_FT_FI7
Number of Residues	1
Details	Site: {"description":"Cleavage; by viral protease; partial"}

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