9MX1
Clostridioides difficile Toxin A with mCDIFA-248-25 Fab
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| C | TYR412-HIS418 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 372 |
| Details | Domain: {"description":"GT44","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 207 |
| Details | Domain: {"description":"Peptidase C80","evidences":[{"source":"PROSITE-ProRule","id":"PRU01107","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"Cell wall-binding 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"Cell wall-binding 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"Cell wall-binding 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"Cell wall-binding 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"Cell wall-binding 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"Cell wall-binding 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"Cell wall-binding 7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"Cell wall-binding 8"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"Cell wall-binding 9"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"Cell wall-binding 10"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"Cell wall-binding 11"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"Cell wall-binding 12"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"Cell wall-binding 13"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"Cell wall-binding 14"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"Cell wall-binding 15"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"Cell wall-binding 16"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"Cell wall-binding 17"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"Cell wall-binding 18"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"Cell wall-binding 19"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"Cell wall-binding 20"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI23 |
| Number of Residues | 372 |
| Details | Region: {"description":"Glucosyltransferase region","evidences":[{"source":"PubMed","id":"29146177","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI24 |
| Number of Residues | 258 |
| Details | Region: {"description":"Autoprocessing region","evidences":[{"source":"PubMed","id":"29146177","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI25 |
| Number of Residues | 695 |
| Details | Region: {"description":"Translocation region","evidences":[{"source":"PubMed","id":"29146177","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI26 |
| Number of Residues | 1 |
| Details | Active site: {"description":"For protease activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01107","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19553670","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27571750","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI27 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile; for protease activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01107","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19553670","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27571750","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI28 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22267739","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22747490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28433497","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3SRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DMV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UQK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UQL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI29 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22267739","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28433497","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3SRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UQK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UQL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI30 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22267739","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3SS1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI31 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22267739","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22747490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28433497","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3SRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SS1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UQK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UQL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI32 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27571750","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4R04","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI33 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19553670","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3HO6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI34 |
| Number of Residues | 1 |
| Details | Site: {"description":"Cleavage; by autolysis","evidences":[{"source":"PubMed","id":"19553670","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
