9MRK
Glutamate activated state of the GluA2-gamma2 complex prepared at 37 degrees C
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 160 |
| Details | TRANSMEM: Helical |
| Chain | Residue | Details |
| A | TYR523-VAL543 | |
| A | ILE611-SER631 | |
| B | TYR523-VAL543 | |
| B | ILE611-SER631 | |
| C | TYR523-VAL543 | |
| C | ILE611-SER631 | |
| D | TYR523-VAL543 | |
| D | ILE611-SER631 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 124 |
| Details | TOPO_DOM: Cytoplasmic |
| Chain | Residue | Details |
| A | SER544-MET585 | |
| A | TRP605-LEU610 | |
| B | SER544-MET585 | |
| B | TRP605-LEU610 | |
| C | SER544-MET585 | |
| C | TRP605-LEU610 | |
| D | SER544-MET585 | |
| D | TRP605-LEU610 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 60 |
| Details | INTRAMEM: Helical; Pore-forming |
| Chain | Residue | Details |
| A | GLN586-VAL601 | |
| B | GLN586-VAL601 | |
| C | GLN586-VAL601 | |
| D | GLN586-VAL601 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | INTRAMEM: |
| Chain | Residue | Details |
| A | GLY602-VAL604 | |
| B | GLY602-VAL604 | |
| C | GLY602-VAL604 | |
| D | GLY602-VAL604 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 696 |
| Details | TOPO_DOM: Extracellular |
| Chain | Residue | Details |
| A | PRO632-ALA806 | |
| B | PRO632-ALA806 | |
| C | PRO632-ALA806 | |
| D | PRO632-ALA806 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Name=M4 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO |
| Chain | Residue | Details |
| A | PRO478 | |
| B | LYS669 | |
| B | MET670 | |
| B | THR720 | |
| C | PRO478 | |
| C | THR480 | |
| C | ARG485 | |
| C | LYS669 | |
| C | MET670 | |
| C | THR720 | |
| D | PRO478 | |
| A | THR480 | |
| D | THR480 | |
| D | ARG485 | |
| D | LYS669 | |
| D | MET670 | |
| D | THR720 | |
| A | ARG485 | |
| A | LYS669 | |
| A | MET670 | |
| A | THR720 | |
| B | PRO478 | |
| B | THR480 | |
| B | ARG485 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 12 |
| Details | SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 |
| Chain | Residue | Details |
| A | ARG453 | |
| D | ARG453 | |
| D | ARG675 | |
| D | TRP767 | |
| A | ARG675 | |
| A | TRP767 | |
| B | ARG453 | |
| B | ARG675 | |
| B | TRP767 | |
| C | ARG453 | |
| C | ARG675 | |
| C | TRP767 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405 |
| Chain | Residue | Details |
| A | GLY648 | |
| B | GLY648 | |
| C | GLY648 | |
| D | GLY648 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293 |
| Chain | Residue | Details |
| A | ALA677 | |
| B | ALA677 | |
| C | ALA677 | |
| D | ALA677 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293 |
| Chain | Residue | Details |
| A | TYR711 | |
| B | TYR711 | |
| C | TYR711 | |
| D | TYR711 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 8 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250 |
| Chain | Residue | Details |
| A | VAL604 | |
| B | VAL604 | |
| C | VAL604 | |
| D | VAL604 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | GLN392 | |
| B | GLN392 | |
| C | GLN392 | |
| D | GLN392 |
