9MQJ
Locally-refined Inactive Mu-Opioid Receptor with Nb6M, NabFab, and isoquinuclidine compound #020_E1
This is a non-PDB format compatible entry.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001965 | molecular_function | G-protein alpha-subunit binding |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0004979 | molecular_function | beta-endorphin receptor activity |
| A | 0004985 | molecular_function | G protein-coupled opioid receptor activity |
| A | 0005245 | molecular_function | voltage-gated calcium channel activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005768 | cellular_component | endosome |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007165 | biological_process | signal transduction |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0007187 | biological_process | G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| A | 0007197 | biological_process | adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway |
| A | 0007200 | biological_process | phospholipase C-activating G protein-coupled receptor signaling pathway |
| A | 0007218 | biological_process | neuropeptide signaling pathway |
| A | 0007600 | biological_process | sensory perception |
| A | 0008285 | biological_process | negative regulation of cell population proliferation |
| A | 0008528 | molecular_function | G protein-coupled peptide receptor activity |
| A | 0016020 | cellular_component | membrane |
| A | 0019233 | biological_process | sensory perception of pain |
| A | 0030424 | cellular_component | axon |
| A | 0030425 | cellular_component | dendrite |
| A | 0031681 | molecular_function | G-protein beta-subunit binding |
| A | 0038003 | biological_process | G protein-coupled opioid receptor signaling pathway |
| A | 0038047 | molecular_function | morphine receptor activity |
| A | 0042923 | molecular_function | neuropeptide binding |
| A | 0042995 | cellular_component | cell projection |
| A | 0043005 | cellular_component | neuron projection |
| A | 0043204 | cellular_component | perikaryon |
| A | 0045202 | cellular_component | synapse |
| A | 0048149 | biological_process | behavioral response to ethanol |
| A | 0050769 | biological_process | positive regulation of neurogenesis |
| A | 0061358 | biological_process | negative regulation of Wnt protein secretion |
| A | 0070374 | biological_process | positive regulation of ERK1 and ERK2 cascade |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0071315 | biological_process | cellular response to morphine |
| A | 0080135 | biological_process | regulation of cellular response to stress |
| A | 2000310 | biological_process | regulation of NMDA receptor activity |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. TSIfTLCTMSVDRYIaV |
| Chain | Residue | Details |
| A | THR155-VAL171 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 106 |
| Details | TOPO_DOM: Extracellular => ECO:0000250|UniProtKB:P42866 |
| Chain | Residue | Details |
| A | MET1-ILE68 | |
| A | MET132-CYS142 | |
| A | ALA208-TRP230 | |
| A | LEU307-THR314 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000250|UniProtKB:P42866 |
| Chain | Residue | Details |
| A | THR69-TYR93 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 115 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:P42866 |
| Chain | Residue | Details |
| A | VAL94-ASN106 | |
| A | ASP166-ASN185 | |
| A | LEU256-ARG279 | |
| A | ALA339-PRO400 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000250|UniProtKB:P42866 |
| Chain | Residue | Details |
| A | ILE107-LEU131 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000250|UniProtKB:P42866 |
| Chain | Residue | Details |
| A | LYS143-VAL165 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000250|UniProtKB:P42866 |
| Chain | Residue | Details |
| A | ALA186-MET207 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000250|UniProtKB:P42866 |
| Chain | Residue | Details |
| A | GLU231-GLY255 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 26 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000250|UniProtKB:P42866 |
| Chain | Residue | Details |
| A | ILE280-ALA306 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000250|UniProtKB:P42866 |
| Chain | Residue | Details |
| A | PHE315-TYR338 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P33535 |
| Chain | Residue | Details |
| A | TYR168 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P42866 |
| Chain | Residue | Details |
| A | SER365 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P33535 |
| Chain | Residue | Details |
| A | THR372 | |
| A | THR396 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P33535 |
| Chain | Residue | Details |
| A | SER377 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000255 |
| Chain | Residue | Details |
| A | CYS353 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 5 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN9 | |
| A | ASN12 | |
| A | ASN33 | |
| A | ASN40 | |
| A | ASN48 |
