9MON

Structure of native murine cardiac thin filament at pCa=5.8 in Ca2+-bound fully activated state (upper strand)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000146	molecular_function	microfilament motor activity
A	0000166	molecular_function	nucleotide binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005884	cellular_component	actin filament
A	0007015	biological_process	actin filament organization
A	0009410	biological_process	response to xenobiotic stimulus
A	0010628	biological_process	positive regulation of gene expression
A	0015629	cellular_component	actin cytoskeleton
A	0016787	molecular_function	hydrolase activity
A	0017022	molecular_function	myosin binding
A	0030017	cellular_component	sarcomere
A	0030027	cellular_component	lamellipodium
A	0030048	biological_process	actin filament-based movement
A	0030175	cellular_component	filopodium
A	0030240	biological_process	skeletal muscle thin filament assembly
A	0031032	biological_process	actomyosin structure organization
A	0031674	cellular_component	I band
A	0033275	biological_process	actin-myosin filament sliding
A	0043066	biological_process	negative regulation of apoptotic process
A	0044297	cellular_component	cell body
A	0045202	cellular_component	synapse
A	0045471	biological_process	response to ethanol
A	0055003	biological_process	cardiac myofibril assembly
A	0055008	biological_process	cardiac muscle tissue morphogenesis
A	0060047	biological_process	heart contraction
A	0060048	biological_process	cardiac muscle contraction
A	0060327	biological_process	cytoplasmic actin-based contraction involved in cell motility
A	0090131	biological_process	mesenchyme migration
A	0098978	cellular_component	glutamatergic synapse
B	0000146	molecular_function	microfilament motor activity
B	0000166	molecular_function	nucleotide binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005884	cellular_component	actin filament
B	0007015	biological_process	actin filament organization
B	0009410	biological_process	response to xenobiotic stimulus
B	0010628	biological_process	positive regulation of gene expression
B	0015629	cellular_component	actin cytoskeleton
B	0016787	molecular_function	hydrolase activity
B	0017022	molecular_function	myosin binding
B	0030017	cellular_component	sarcomere
B	0030027	cellular_component	lamellipodium
B	0030048	biological_process	actin filament-based movement
B	0030175	cellular_component	filopodium
B	0030240	biological_process	skeletal muscle thin filament assembly
B	0031032	biological_process	actomyosin structure organization
B	0031674	cellular_component	I band
B	0033275	biological_process	actin-myosin filament sliding
B	0043066	biological_process	negative regulation of apoptotic process
B	0044297	cellular_component	cell body
B	0045202	cellular_component	synapse
B	0045471	biological_process	response to ethanol
B	0055003	biological_process	cardiac myofibril assembly
B	0055008	biological_process	cardiac muscle tissue morphogenesis
B	0060047	biological_process	heart contraction
B	0060048	biological_process	cardiac muscle contraction
B	0060327	biological_process	cytoplasmic actin-based contraction involved in cell motility
B	0090131	biological_process	mesenchyme migration
B	0098978	cellular_component	glutamatergic synapse
C	0000146	molecular_function	microfilament motor activity
C	0000166	molecular_function	nucleotide binding
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005856	cellular_component	cytoskeleton
C	0005884	cellular_component	actin filament
C	0007015	biological_process	actin filament organization
C	0009410	biological_process	response to xenobiotic stimulus
C	0010628	biological_process	positive regulation of gene expression
C	0015629	cellular_component	actin cytoskeleton
C	0016787	molecular_function	hydrolase activity
C	0017022	molecular_function	myosin binding
C	0030017	cellular_component	sarcomere
C	0030027	cellular_component	lamellipodium
C	0030048	biological_process	actin filament-based movement
C	0030175	cellular_component	filopodium
C	0030240	biological_process	skeletal muscle thin filament assembly
C	0031032	biological_process	actomyosin structure organization
C	0031674	cellular_component	I band
C	0033275	biological_process	actin-myosin filament sliding
C	0043066	biological_process	negative regulation of apoptotic process
C	0044297	cellular_component	cell body
C	0045202	cellular_component	synapse
C	0045471	biological_process	response to ethanol
C	0055003	biological_process	cardiac myofibril assembly
C	0055008	biological_process	cardiac muscle tissue morphogenesis
C	0060047	biological_process	heart contraction
C	0060048	biological_process	cardiac muscle contraction
C	0060327	biological_process	cytoplasmic actin-based contraction involved in cell motility
C	0090131	biological_process	mesenchyme migration
C	0098978	cellular_component	glutamatergic synapse
D	0000146	molecular_function	microfilament motor activity
D	0000166	molecular_function	nucleotide binding
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005856	cellular_component	cytoskeleton
D	0005884	cellular_component	actin filament
D	0007015	biological_process	actin filament organization
D	0009410	biological_process	response to xenobiotic stimulus
D	0010628	biological_process	positive regulation of gene expression
D	0015629	cellular_component	actin cytoskeleton
D	0016787	molecular_function	hydrolase activity
D	0017022	molecular_function	myosin binding
D	0030017	cellular_component	sarcomere
D	0030027	cellular_component	lamellipodium
D	0030048	biological_process	actin filament-based movement
D	0030175	cellular_component	filopodium
D	0030240	biological_process	skeletal muscle thin filament assembly
D	0031032	biological_process	actomyosin structure organization
D	0031674	cellular_component	I band
D	0033275	biological_process	actin-myosin filament sliding
D	0043066	biological_process	negative regulation of apoptotic process
D	0044297	cellular_component	cell body
D	0045202	cellular_component	synapse
D	0045471	biological_process	response to ethanol
D	0055003	biological_process	cardiac myofibril assembly
D	0055008	biological_process	cardiac muscle tissue morphogenesis
D	0060047	biological_process	heart contraction
D	0060048	biological_process	cardiac muscle contraction
D	0060327	biological_process	cytoplasmic actin-based contraction involved in cell motility
D	0090131	biological_process	mesenchyme migration
D	0098978	cellular_component	glutamatergic synapse
E	0000146	molecular_function	microfilament motor activity
E	0000166	molecular_function	nucleotide binding
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005856	cellular_component	cytoskeleton
E	0005884	cellular_component	actin filament
E	0007015	biological_process	actin filament organization
E	0009410	biological_process	response to xenobiotic stimulus
E	0010628	biological_process	positive regulation of gene expression
E	0015629	cellular_component	actin cytoskeleton
E	0016787	molecular_function	hydrolase activity
E	0017022	molecular_function	myosin binding
E	0030017	cellular_component	sarcomere
E	0030027	cellular_component	lamellipodium
E	0030048	biological_process	actin filament-based movement
E	0030175	cellular_component	filopodium
E	0030240	biological_process	skeletal muscle thin filament assembly
E	0031032	biological_process	actomyosin structure organization
E	0031674	cellular_component	I band
E	0033275	biological_process	actin-myosin filament sliding
E	0043066	biological_process	negative regulation of apoptotic process
E	0044297	cellular_component	cell body
E	0045202	cellular_component	synapse
E	0045471	biological_process	response to ethanol
E	0055003	biological_process	cardiac myofibril assembly
E	0055008	biological_process	cardiac muscle tissue morphogenesis
E	0060047	biological_process	heart contraction
E	0060048	biological_process	cardiac muscle contraction
E	0060327	biological_process	cytoplasmic actin-based contraction involved in cell motility
E	0090131	biological_process	mesenchyme migration
E	0098978	cellular_component	glutamatergic synapse
F	0000146	molecular_function	microfilament motor activity
F	0000166	molecular_function	nucleotide binding
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005856	cellular_component	cytoskeleton
F	0005884	cellular_component	actin filament
F	0007015	biological_process	actin filament organization
F	0009410	biological_process	response to xenobiotic stimulus
F	0010628	biological_process	positive regulation of gene expression
F	0015629	cellular_component	actin cytoskeleton
F	0016787	molecular_function	hydrolase activity
F	0017022	molecular_function	myosin binding
F	0030017	cellular_component	sarcomere
F	0030027	cellular_component	lamellipodium
F	0030048	biological_process	actin filament-based movement
F	0030175	cellular_component	filopodium
F	0030240	biological_process	skeletal muscle thin filament assembly
F	0031032	biological_process	actomyosin structure organization
F	0031674	cellular_component	I band
F	0033275	biological_process	actin-myosin filament sliding
F	0043066	biological_process	negative regulation of apoptotic process
F	0044297	cellular_component	cell body
F	0045202	cellular_component	synapse
F	0045471	biological_process	response to ethanol
F	0055003	biological_process	cardiac myofibril assembly
F	0055008	biological_process	cardiac muscle tissue morphogenesis
F	0060047	biological_process	heart contraction
F	0060048	biological_process	cardiac muscle contraction
F	0060327	biological_process	cytoplasmic actin-based contraction involved in cell motility
F	0090131	biological_process	mesenchyme migration
F	0098978	cellular_component	glutamatergic synapse
G	0000146	molecular_function	microfilament motor activity
G	0000166	molecular_function	nucleotide binding
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005856	cellular_component	cytoskeleton
G	0005884	cellular_component	actin filament
G	0007015	biological_process	actin filament organization
G	0009410	biological_process	response to xenobiotic stimulus
G	0010628	biological_process	positive regulation of gene expression
G	0015629	cellular_component	actin cytoskeleton
G	0016787	molecular_function	hydrolase activity
G	0017022	molecular_function	myosin binding
G	0030017	cellular_component	sarcomere
G	0030027	cellular_component	lamellipodium
G	0030048	biological_process	actin filament-based movement
G	0030175	cellular_component	filopodium
G	0030240	biological_process	skeletal muscle thin filament assembly
G	0031032	biological_process	actomyosin structure organization
G	0031674	cellular_component	I band
G	0033275	biological_process	actin-myosin filament sliding
G	0043066	biological_process	negative regulation of apoptotic process
G	0044297	cellular_component	cell body
G	0045202	cellular_component	synapse
G	0045471	biological_process	response to ethanol
G	0055003	biological_process	cardiac myofibril assembly
G	0055008	biological_process	cardiac muscle tissue morphogenesis
G	0060047	biological_process	heart contraction
G	0060048	biological_process	cardiac muscle contraction
G	0060327	biological_process	cytoplasmic actin-based contraction involved in cell motility
G	0090131	biological_process	mesenchyme migration
G	0098978	cellular_component	glutamatergic synapse
H	0002086	biological_process	diaphragm contraction
H	0003009	biological_process	skeletal muscle contraction
H	0005509	molecular_function	calcium ion binding
H	0005861	cellular_component	troponin complex
H	0006937	biological_process	regulation of muscle contraction
H	0008092	molecular_function	cytoskeletal protein binding
H	0010038	biological_process	response to metal ion
H	0014883	biological_process	transition between fast and slow fiber
H	0030017	cellular_component	sarcomere
H	0030049	biological_process	muscle filament sliding
H	0031013	molecular_function	troponin I binding
H	0031014	molecular_function	troponin T binding
H	0032972	biological_process	regulation of muscle filament sliding speed
H	0042803	molecular_function	protein homodimerization activity
H	0043292	cellular_component	contractile muscle fiber
H	0046872	molecular_function	metal ion binding
H	0048306	molecular_function	calcium-dependent protein binding
H	0051015	molecular_function	actin filament binding
H	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
H	0060048	biological_process	cardiac muscle contraction
H	0086003	biological_process	cardiac muscle cell contraction
H	1990584	cellular_component	cardiac Troponin complex
I	0001570	biological_process	vasculogenesis
I	0001980	biological_process	regulation of systemic arterial blood pressure by ischemic conditions
I	0003009	biological_process	skeletal muscle contraction
I	0003779	molecular_function	actin binding
I	0005737	cellular_component	cytoplasm
I	0005861	cellular_component	troponin complex
I	0006874	biological_process	intracellular calcium ion homeostasis
I	0006937	biological_process	regulation of muscle contraction
I	0006940	biological_process	regulation of smooth muscle contraction
I	0006941	biological_process	striated muscle contraction
I	0007507	biological_process	heart development
I	0010882	biological_process	regulation of cardiac muscle contraction by calcium ion signaling
I	0019855	molecular_function	calcium channel inhibitor activity
I	0019901	molecular_function	protein kinase binding
I	0019904	molecular_function	protein domain specific binding
I	0030016	cellular_component	myofibril
I	0030017	cellular_component	sarcomere
I	0030049	biological_process	muscle filament sliding
I	0030172	molecular_function	troponin C binding
I	0031014	molecular_function	troponin T binding
I	0043292	cellular_component	contractile muscle fiber
I	0048306	molecular_function	calcium-dependent protein binding
I	0051015	molecular_function	actin filament binding
I	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
I	0060047	biological_process	heart contraction
I	0060048	biological_process	cardiac muscle contraction
I	0097512	cellular_component	cardiac myofibril
I	1990584	cellular_component	cardiac Troponin complex
J	0000146	molecular_function	microfilament motor activity
J	0003779	molecular_function	actin binding
J	0005200	molecular_function	structural constituent of cytoskeleton
J	0005523	molecular_function	tropomyosin binding
J	0005737	cellular_component	cytoplasm
J	0005861	cellular_component	troponin complex
J	0005865	cellular_component	striated muscle thin filament
J	0006936	biological_process	muscle contraction
J	0007507	biological_process	heart development
J	0008016	biological_process	regulation of heart contraction
J	0009617	biological_process	response to bacterium
J	0030016	cellular_component	myofibril
J	0030017	cellular_component	sarcomere
J	0030049	biological_process	muscle filament sliding
J	0030172	molecular_function	troponin C binding
J	0030674	molecular_function	protein-macromolecule adaptor activity
J	0031013	molecular_function	troponin I binding
J	0032780	biological_process	negative regulation of ATP-dependent activity
J	0032781	biological_process	positive regulation of ATP-dependent activity
J	0032972	biological_process	regulation of muscle filament sliding speed
J	0042802	molecular_function	identical protein binding
J	0044877	molecular_function	protein-containing complex binding
J	0045214	biological_process	sarcomere organization
J	0051592	biological_process	response to calcium ion
J	0051764	biological_process	actin crosslink formation
J	0055009	biological_process	atrial cardiac muscle tissue morphogenesis
J	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
J	0060048	biological_process	cardiac muscle contraction
J	0097512	cellular_component	cardiac myofibril
J	1990584	cellular_component	cardiac Troponin complex
K	0000146	molecular_function	microfilament motor activity
K	0003779	molecular_function	actin binding
K	0005200	molecular_function	structural constituent of cytoskeleton
K	0005523	molecular_function	tropomyosin binding
K	0005737	cellular_component	cytoplasm
K	0005861	cellular_component	troponin complex
K	0005865	cellular_component	striated muscle thin filament
K	0006936	biological_process	muscle contraction
K	0007507	biological_process	heart development
K	0008016	biological_process	regulation of heart contraction
K	0009617	biological_process	response to bacterium
K	0030016	cellular_component	myofibril
K	0030017	cellular_component	sarcomere
K	0030049	biological_process	muscle filament sliding
K	0030172	molecular_function	troponin C binding
K	0030674	molecular_function	protein-macromolecule adaptor activity
K	0031013	molecular_function	troponin I binding
K	0032780	biological_process	negative regulation of ATP-dependent activity
K	0032781	biological_process	positive regulation of ATP-dependent activity
K	0032972	biological_process	regulation of muscle filament sliding speed
K	0042802	molecular_function	identical protein binding
K	0044877	molecular_function	protein-containing complex binding
K	0045214	biological_process	sarcomere organization
K	0051592	biological_process	response to calcium ion
K	0051764	biological_process	actin crosslink formation
K	0055009	biological_process	atrial cardiac muscle tissue morphogenesis
K	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
K	0060048	biological_process	cardiac muscle contraction
K	0097512	cellular_component	cardiac myofibril
K	1990584	cellular_component	cardiac Troponin complex
L	0001701	biological_process	in utero embryonic development
L	0001725	cellular_component	stress fiber
L	0003065	biological_process	positive regulation of heart rate by epinephrine
L	0003779	molecular_function	actin binding
L	0005200	molecular_function	structural constituent of cytoskeleton
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005856	cellular_component	cytoskeleton
L	0005862	cellular_component	muscle thin filament tropomyosin
L	0005884	cellular_component	actin filament
L	0007015	biological_process	actin filament organization
L	0008092	molecular_function	cytoskeletal protein binding
L	0008360	biological_process	regulation of cell shape
L	0015629	cellular_component	actin cytoskeleton
L	0030016	cellular_component	myofibril
L	0030049	biological_process	muscle filament sliding
L	0030336	biological_process	negative regulation of cell migration
L	0031529	biological_process	ruffle organization
L	0032059	cellular_component	bleb
L	0032587	cellular_component	ruffle membrane
L	0032991	cellular_component	protein-containing complex
L	0042060	biological_process	wound healing
L	0042802	molecular_function	identical protein binding
L	0042803	molecular_function	protein homodimerization activity
L	0045214	biological_process	sarcomere organization
L	0045785	biological_process	positive regulation of cell adhesion
L	0046982	molecular_function	protein heterodimerization activity
L	0051015	molecular_function	actin filament binding
L	0051496	biological_process	positive regulation of stress fiber assembly
L	0051693	biological_process	actin filament capping
L	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
L	0060048	biological_process	cardiac muscle contraction
L	0097718	molecular_function	disordered domain specific binding
L	1904706	biological_process	negative regulation of vascular associated smooth muscle cell proliferation
L	1904753	biological_process	negative regulation of vascular associated smooth muscle cell migration
M	0001701	biological_process	in utero embryonic development
M	0001725	cellular_component	stress fiber
M	0003065	biological_process	positive regulation of heart rate by epinephrine
M	0003779	molecular_function	actin binding
M	0005200	molecular_function	structural constituent of cytoskeleton
M	0005515	molecular_function	protein binding
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0005856	cellular_component	cytoskeleton
M	0005862	cellular_component	muscle thin filament tropomyosin
M	0005884	cellular_component	actin filament
M	0007015	biological_process	actin filament organization
M	0008092	molecular_function	cytoskeletal protein binding
M	0008360	biological_process	regulation of cell shape
M	0015629	cellular_component	actin cytoskeleton
M	0030016	cellular_component	myofibril
M	0030049	biological_process	muscle filament sliding
M	0030336	biological_process	negative regulation of cell migration
M	0031529	biological_process	ruffle organization
M	0032059	cellular_component	bleb
M	0032587	cellular_component	ruffle membrane
M	0032991	cellular_component	protein-containing complex
M	0042060	biological_process	wound healing
M	0042802	molecular_function	identical protein binding
M	0042803	molecular_function	protein homodimerization activity
M	0045214	biological_process	sarcomere organization
M	0045785	biological_process	positive regulation of cell adhesion
M	0046982	molecular_function	protein heterodimerization activity
M	0051015	molecular_function	actin filament binding
M	0051496	biological_process	positive regulation of stress fiber assembly
M	0051693	biological_process	actin filament capping
M	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
M	0060048	biological_process	cardiac muscle contraction
M	0097718	molecular_function	disordered domain specific binding
M	1904706	biological_process	negative regulation of vascular associated smooth muscle cell proliferation
M	1904753	biological_process	negative regulation of vascular associated smooth muscle cell migration
N	0001701	biological_process	in utero embryonic development
N	0001725	cellular_component	stress fiber
N	0003065	biological_process	positive regulation of heart rate by epinephrine
N	0003779	molecular_function	actin binding
N	0005200	molecular_function	structural constituent of cytoskeleton
N	0005515	molecular_function	protein binding
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0005856	cellular_component	cytoskeleton
N	0005862	cellular_component	muscle thin filament tropomyosin
N	0005884	cellular_component	actin filament
N	0007015	biological_process	actin filament organization
N	0008092	molecular_function	cytoskeletal protein binding
N	0008360	biological_process	regulation of cell shape
N	0015629	cellular_component	actin cytoskeleton
N	0030016	cellular_component	myofibril
N	0030049	biological_process	muscle filament sliding
N	0030336	biological_process	negative regulation of cell migration
N	0031529	biological_process	ruffle organization
N	0032059	cellular_component	bleb
N	0032587	cellular_component	ruffle membrane
N	0032991	cellular_component	protein-containing complex
N	0042060	biological_process	wound healing
N	0042802	molecular_function	identical protein binding
N	0042803	molecular_function	protein homodimerization activity
N	0045214	biological_process	sarcomere organization
N	0045785	biological_process	positive regulation of cell adhesion
N	0046982	molecular_function	protein heterodimerization activity
N	0051015	molecular_function	actin filament binding
N	0051496	biological_process	positive regulation of stress fiber assembly
N	0051693	biological_process	actin filament capping
N	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
N	0060048	biological_process	cardiac muscle contraction
N	0097718	molecular_function	disordered domain specific binding
N	1904706	biological_process	negative regulation of vascular associated smooth muscle cell proliferation
N	1904753	biological_process	negative regulation of vascular associated smooth muscle cell migration
O	0001701	biological_process	in utero embryonic development
O	0001725	cellular_component	stress fiber
O	0003065	biological_process	positive regulation of heart rate by epinephrine
O	0003779	molecular_function	actin binding
O	0005200	molecular_function	structural constituent of cytoskeleton
O	0005515	molecular_function	protein binding
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0005856	cellular_component	cytoskeleton
O	0005862	cellular_component	muscle thin filament tropomyosin
O	0005884	cellular_component	actin filament
O	0007015	biological_process	actin filament organization
O	0008092	molecular_function	cytoskeletal protein binding
O	0008360	biological_process	regulation of cell shape
O	0015629	cellular_component	actin cytoskeleton
O	0030016	cellular_component	myofibril
O	0030049	biological_process	muscle filament sliding
O	0030336	biological_process	negative regulation of cell migration
O	0031529	biological_process	ruffle organization
O	0032059	cellular_component	bleb
O	0032587	cellular_component	ruffle membrane
O	0032991	cellular_component	protein-containing complex
O	0042060	biological_process	wound healing
O	0042802	molecular_function	identical protein binding
O	0042803	molecular_function	protein homodimerization activity
O	0045214	biological_process	sarcomere organization
O	0045785	biological_process	positive regulation of cell adhesion
O	0046982	molecular_function	protein heterodimerization activity
O	0051015	molecular_function	actin filament binding
O	0051496	biological_process	positive regulation of stress fiber assembly
O	0051693	biological_process	actin filament capping
O	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
O	0060048	biological_process	cardiac muscle contraction
O	0097718	molecular_function	disordered domain specific binding
O	1904706	biological_process	negative regulation of vascular associated smooth muscle cell proliferation
O	1904753	biological_process	negative regulation of vascular associated smooth muscle cell migration

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DEDGSGTVDfdEF

Chain	Residue	Details
H	ASP65-PHE77
H	ASP105-LEU117
H	ASP141-PHE153

---

site_id	PS00326
Number of Residues	9
Details	TROPOMYOSIN Tropomyosins signature. LKEAEtRAE

Chain	Residue	Details
L	LEU232-GLU240

---

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
A	TYR53-GLY63

---

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WISKqEYDE

Chain	Residue	Details
A	TRP356-GLU364

---

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR

Chain	Residue	Details
A	LEU104-ARG116

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	Modified residue: {"description":"Methionine (R)-sulfoxide","evidences":[{"source":"PubMed","id":"23911929","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	7
Details	Modified residue: {"description":"Tele-methylhistidine","evidences":[{"source":"UniProtKB","id":"P62739","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	7
Details	Modified residue: {"description":"N6-methyllysine","evidences":[{"source":"UniProtKB","id":"P68032","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	35
Details	Domain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	35
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	35
Details	Domain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	33
Details	Domain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	15
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	13
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	21
Details	Region: {"description":"Involved in binding TNC and actin"}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Site: {"description":"Involved in TNI-TNT interactions"}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PKC/PRKCE","evidences":[{"source":"PubMed","id":"16445938","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	3
Details	Modified residue: {"description":"Phosphothreonine; by STK4/MST1","evidences":[{"source":"UniProtKB","id":"P19429","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P19429","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P19429","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by PKC/PRKCA and RAF1","evidences":[{"source":"PubMed","id":"12832403","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	114
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P04692","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	52
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	2
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"UniProtKB","id":"P09493","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P04692","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---