9MO0
Cryo-EM structure of human MPC in complex with AKOS005153046
This is a non-PDB format compatible entry.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005743 | cellular_component | mitochondrial inner membrane |
| A | 0006850 | biological_process | pyruvate import into mitochondria |
| A | 0016020 | cellular_component | membrane |
| A | 0050833 | molecular_function | pyruvate transmembrane transporter activity |
| A | 0098800 | cellular_component | inner mitochondrial membrane protein complex |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005743 | cellular_component | mitochondrial inner membrane |
| B | 0006086 | biological_process | pyruvate decarboxylation to acetyl-CoA |
| B | 0006850 | biological_process | pyruvate import into mitochondria |
| B | 0016020 | cellular_component | membrane |
| B | 0035774 | biological_process | positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0050833 | molecular_function | pyruvate transmembrane transporter activity |
| B | 0098800 | cellular_component | inner mitochondrial membrane protein complex |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
| Chain | Residue | Details |
| E | TYR197-HIS203 | |
| D | TYR204-HIS210 |
| site_id | PS01037 |
| Number of Residues | 18 |
| Details | SBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN |
| Chain | Residue | Details |
| F | PRO108-ASN125 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 55 |
| Details | TOPO_DOM: Mitochondrial matrix => ECO:0000305|PubMed:27317664 |
| Chain | Residue | Details |
| A | ALA2-ASP20 | |
| A | LYS72-ALA109 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 38 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | TYR21-ILE41 | |
| A | GLY53-TYR71 | |
| B | LEU96-TRP115 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | TOPO_DOM: Mitochondrial intermembrane => ECO:0000305|PubMed:27317664 |
| Chain | Residue | Details |
| A | ASN42-SER52 | |
| B | ARG116-LYS127 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0007744|PubMed:25944712 |
| Chain | Residue | Details |
| A | ALA2 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P63030 |
| Chain | Residue | Details |
| A | LYS72 |
