9MJ9
Condensing wing of FASN with phosphopantetheine-modified partial ACP
Functional Information from PROSITE/UniProt
| site_id | PS00606 |
| Number of Residues | 17 |
| Details | KS3_1 Ketosynthase family 3 (KS3) active site signature. GPSiaLDtACSSSlmAL |
| Chain | Residue | Details |
| A | GLY152-LEU168 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; alternate => ECO:0000250|UniProtKB:P12785 |
| Chain | Residue | Details |
| C | 4HH2156 | |
| A | HIS293 | |
| A | HIS331 | |
| B | CYS161 | |
| B | HIS293 | |
| B | HIS331 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: For malonyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU10022 |
| Chain | Residue | Details |
| A | SER581 | |
| B | SER581 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P19096 |
| Chain | Residue | Details |
| A | ASP647 | |
| A | PHE671 | |
| A | ARG773 | |
| B | ASP647 | |
| B | PHE671 | |
| B | ARG773 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylmethionine => ECO:0000269|Ref.7, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895 |
| Chain | Residue | Details |
| A | MET1 | |
| B | MET1 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER63 | |
| B | SER63 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 10 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS70 | |
| B | LYS673 | |
| A | LYS298 | |
| A | LYS436 | |
| A | LYS528 | |
| A | LYS673 | |
| B | LYS70 | |
| B | LYS298 | |
| B | LYS436 | |
| B | LYS528 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER207 | |
| B | SER207 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P19096 |
| Chain | Residue | Details |
| A | SER725 | |
| B | SER725 |
