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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9MIE

Human NLRP3 complex with compound 2 in the closed hexamer

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
C0000139cellular_componentGolgi membrane
C0000166molecular_functionnucleotide binding
C0002221biological_processpattern recognition receptor signaling pathway
C0002376biological_processimmune system process
C0002674biological_processnegative regulation of acute inflammatory response
C0002830biological_processpositive regulation of type 2 immune response
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005576cellular_componentextracellular region
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005783cellular_componentendoplasmic reticulum
C0005794cellular_componentGolgi apparatus
C0005815cellular_componentmicrotubule organizing center
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0006355biological_processregulation of DNA-templated transcription
C0006915biological_processapoptotic process
C0006952biological_processdefense response
C0006954biological_processinflammatory response
C0007165biological_processsignal transduction
C0007231biological_processosmosensory signaling pathway
C0009306biological_processprotein secretion
C0009595biological_processdetection of biotic stimulus
C0009615biological_processresponse to virus
C0016020cellular_componentmembrane
C0016787molecular_functionhydrolase activity
C0016887molecular_functionATP hydrolysis activity
C0030674molecular_functionprotein-macromolecule adaptor activity
C0031021cellular_componentinterphase microtubule organizing center
C0032691biological_processnegative regulation of interleukin-1 beta production
C0032731biological_processpositive regulation of interleukin-1 beta production
C0032741biological_processpositive regulation of interleukin-18 production
C0032753biological_processpositive regulation of interleukin-4 production
C0035591molecular_functionsignaling adaptor activity
C0035655biological_processinterleukin-18-mediated signaling pathway
C0042802molecular_functionidentical protein binding
C0042834molecular_functionpeptidoglycan binding
C0043531molecular_functionADP binding
C0043565molecular_functionsequence-specific DNA binding
C0044546biological_processNLRP3 inflammasome complex assembly
C0045087biological_processinnate immune response
C0045630biological_processpositive regulation of T-helper 2 cell differentiation
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0050727biological_processregulation of inflammatory response
C0050728biological_processnegative regulation of inflammatory response
C0050729biological_processpositive regulation of inflammatory response
C0051092biological_processpositive regulation of NF-kappaB transcription factor activity
C0051260biological_processprotein homooligomerization
C0051604biological_processprotein maturation
C0060090molecular_functionmolecular adaptor activity
C0061702cellular_componentcanonical inflammasome complex
C0070269biological_processpyroptotic inflammatory response
C0070273molecular_functionphosphatidylinositol-4-phosphate binding
C0070498biological_processinterleukin-1-mediated signaling pathway
C0071222biological_processcellular response to lipopolysaccharide
C0072559cellular_componentNLRP3 inflammasome complex
C0098586biological_processcellular response to virus
C0140297molecular_functionDNA-binding transcription factor binding
C0140299molecular_functionmolecular sensor activity
C0140608molecular_functioncysteine-type endopeptidase activator activity
C0140693molecular_functionmolecular condensate scaffold activity
C1900227biological_processpositive regulation of NLRP3 inflammasome complex assembly
C1901223biological_processnegative regulation of non-canonical NF-kappaB signal transduction
C1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
C1901981molecular_functionphosphatidylinositol phosphate binding
C2000553biological_processpositive regulation of T-helper 2 cell cytokine production
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues20
DetailsRepeat: {"description":"LRR 1"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues21
DetailsRepeat: {"description":"LRR 2"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues20
DetailsRepeat: {"description":"LRR 3"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues21
DetailsRepeat: {"description":"LRR 4"}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues20
DetailsRepeat: {"description":"LRR 5"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues21
DetailsRepeat: {"description":"LRR 6"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues20
DetailsRepeat: {"description":"LRR 7"}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues21
DetailsRepeat: {"description":"LRR 8"}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues21
DetailsRepeat: {"description":"LRR 9"}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues4
DetailsMotif: {"description":"KFERQ-like motif 1","evidences":[{"source":"PubMed","id":"36586411","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues4
DetailsMotif: {"description":"KFERQ-like motif 2","evidences":[{"source":"PubMed","id":"36586411","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues4
DetailsMotif: {"description":"KFERQ-like motif 3","evidences":[{"source":"PubMed","id":"36586411","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues4
DetailsMotif: {"description":"KFERQ-like motif 4","evidences":[{"source":"PubMed","id":"36586411","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35254907","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"36142182","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"36442502","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7VTP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ZGU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8EJ4","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00136","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17483456","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34687713","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35114687","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35254907","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"36142182","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"36442502","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7ALV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PZC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VTP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ZGU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8EJ4","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"34687713","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35114687","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35254907","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"36142182","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7ALV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PZC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VTP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ZGU","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues4
DetailsModified residue: {"description":"Phosphotyrosine; by BTK","evidences":[{"source":"PubMed","id":"34554188","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q8R4B8","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"28943315","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"35114687","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by LATS1 and LATS2","evidences":[{"source":"PubMed","id":"39173637","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues3
DetailsModified residue: {"description":"Phosphoserine; by CSNK1A1","evidences":[{"source":"PubMed","id":"34615873","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"27043286","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues3
DetailsLipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"36586411","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues1
DetailsLipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"39173637","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"37575012","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"34615873","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

238895

PDB entries from 2025-07-16

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