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9MEU

CXCR4 tetramer bound to 4 CXCL12 dimers

Functional Information from GO Data
ChainGOidnamespacecontents
A0001618molecular_functionvirus receptor activity
A0001666biological_processresponse to hypoxia
A0002407biological_processdendritic cell chemotaxis
A0003779molecular_functionactin binding
A0004930molecular_functionG protein-coupled receptor activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005769cellular_componentearly endosome
A0005770cellular_componentlate endosome
A0005886cellular_componentplasma membrane
A0006915biological_processapoptotic process
A0006954biological_processinflammatory response
A0006955biological_processimmune response
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0007420biological_processbrain development
A0009615biological_processresponse to virus
A0009897cellular_componentexternal side of plasma membrane
A0009986cellular_componentcell surface
A0015026molecular_functioncoreceptor activity
A0016477biological_processcell migration
A0016493molecular_functionC-C chemokine receptor activity
A0016494molecular_functionC-X-C chemokine receptor activity
A0019722biological_processcalcium-mediated signaling
A0019957molecular_functionC-C chemokine binding
A0022008biological_processneurogenesis
A0030155biological_processregulation of cell adhesion
A0030334biological_processregulation of cell migration
A0030335biological_processpositive regulation of cell migration
A0031252cellular_componentcell leading edge
A0031410cellular_componentcytoplasmic vesicle
A0031625molecular_functionubiquitin protein ligase binding
A0032027molecular_functionmyosin light chain binding
A0032991cellular_componentprotein-containing complex
A0038147molecular_functionC-X-C motif chemokine 12 receptor activity
A0038160biological_processCXCL12-activated CXCR4 signaling pathway
A0043130molecular_functionubiquitin binding
A0043217biological_processmyelin maintenance
A0046718biological_processsymbiont entry into host cell
A0048714biological_processpositive regulation of oligodendrocyte differentiation
A0060326biological_processcell chemotaxis
A0070062cellular_componentextracellular exosome
A0070098biological_processchemokine-mediated signaling pathway
A0070161cellular_componentanchoring junction
A0071345biological_processcellular response to cytokine stimulus
A0120162biological_processpositive regulation of cold-induced thermogenesis
A1904018biological_processpositive regulation of vasculature development
A2000448biological_processpositive regulation of macrophage migration inhibitory factor signaling pathway
B0001618molecular_functionvirus receptor activity
B0001666biological_processresponse to hypoxia
B0002407biological_processdendritic cell chemotaxis
B0003779molecular_functionactin binding
B0004930molecular_functionG protein-coupled receptor activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005764cellular_componentlysosome
B0005769cellular_componentearly endosome
B0005770cellular_componentlate endosome
B0005886cellular_componentplasma membrane
B0006915biological_processapoptotic process
B0006954biological_processinflammatory response
B0006955biological_processimmune response
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
B0007204biological_processpositive regulation of cytosolic calcium ion concentration
B0007420biological_processbrain development
B0009615biological_processresponse to virus
B0009897cellular_componentexternal side of plasma membrane
B0009986cellular_componentcell surface
B0015026molecular_functioncoreceptor activity
B0016477biological_processcell migration
B0016493molecular_functionC-C chemokine receptor activity
B0016494molecular_functionC-X-C chemokine receptor activity
B0019722biological_processcalcium-mediated signaling
B0019957molecular_functionC-C chemokine binding
B0022008biological_processneurogenesis
B0030155biological_processregulation of cell adhesion
B0030334biological_processregulation of cell migration
B0030335biological_processpositive regulation of cell migration
B0031252cellular_componentcell leading edge
B0031410cellular_componentcytoplasmic vesicle
B0031625molecular_functionubiquitin protein ligase binding
B0032027molecular_functionmyosin light chain binding
B0032991cellular_componentprotein-containing complex
B0038147molecular_functionC-X-C motif chemokine 12 receptor activity
B0038160biological_processCXCL12-activated CXCR4 signaling pathway
B0043130molecular_functionubiquitin binding
B0043217biological_processmyelin maintenance
B0046718biological_processsymbiont entry into host cell
B0048714biological_processpositive regulation of oligodendrocyte differentiation
B0060326biological_processcell chemotaxis
B0070062cellular_componentextracellular exosome
B0070098biological_processchemokine-mediated signaling pathway
B0070161cellular_componentanchoring junction
B0071345biological_processcellular response to cytokine stimulus
B0120162biological_processpositive regulation of cold-induced thermogenesis
B1904018biological_processpositive regulation of vasculature development
B2000448biological_processpositive regulation of macrophage migration inhibitory factor signaling pathway
C0001618molecular_functionvirus receptor activity
C0001666biological_processresponse to hypoxia
C0002407biological_processdendritic cell chemotaxis
C0003779molecular_functionactin binding
C0004930molecular_functionG protein-coupled receptor activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005764cellular_componentlysosome
C0005769cellular_componentearly endosome
C0005770cellular_componentlate endosome
C0005886cellular_componentplasma membrane
C0006915biological_processapoptotic process
C0006954biological_processinflammatory response
C0006955biological_processimmune response
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
C0007204biological_processpositive regulation of cytosolic calcium ion concentration
C0007420biological_processbrain development
C0009615biological_processresponse to virus
C0009897cellular_componentexternal side of plasma membrane
C0009986cellular_componentcell surface
C0015026molecular_functioncoreceptor activity
C0016477biological_processcell migration
C0016493molecular_functionC-C chemokine receptor activity
C0016494molecular_functionC-X-C chemokine receptor activity
C0019722biological_processcalcium-mediated signaling
C0019957molecular_functionC-C chemokine binding
C0022008biological_processneurogenesis
C0030155biological_processregulation of cell adhesion
C0030334biological_processregulation of cell migration
C0030335biological_processpositive regulation of cell migration
C0031252cellular_componentcell leading edge
C0031410cellular_componentcytoplasmic vesicle
C0031625molecular_functionubiquitin protein ligase binding
C0032027molecular_functionmyosin light chain binding
C0032991cellular_componentprotein-containing complex
C0038147molecular_functionC-X-C motif chemokine 12 receptor activity
C0038160biological_processCXCL12-activated CXCR4 signaling pathway
C0043130molecular_functionubiquitin binding
C0043217biological_processmyelin maintenance
C0046718biological_processsymbiont entry into host cell
C0048714biological_processpositive regulation of oligodendrocyte differentiation
C0060326biological_processcell chemotaxis
C0070062cellular_componentextracellular exosome
C0070098biological_processchemokine-mediated signaling pathway
C0070161cellular_componentanchoring junction
C0071345biological_processcellular response to cytokine stimulus
C0120162biological_processpositive regulation of cold-induced thermogenesis
C1904018biological_processpositive regulation of vasculature development
C2000448biological_processpositive regulation of macrophage migration inhibitory factor signaling pathway
D0001618molecular_functionvirus receptor activity
D0001666biological_processresponse to hypoxia
D0002407biological_processdendritic cell chemotaxis
D0003779molecular_functionactin binding
D0004930molecular_functionG protein-coupled receptor activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005764cellular_componentlysosome
D0005769cellular_componentearly endosome
D0005770cellular_componentlate endosome
D0005886cellular_componentplasma membrane
D0006915biological_processapoptotic process
D0006954biological_processinflammatory response
D0006955biological_processimmune response
D0007165biological_processsignal transduction
D0007186biological_processG protein-coupled receptor signaling pathway
D0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
D0007204biological_processpositive regulation of cytosolic calcium ion concentration
D0007420biological_processbrain development
D0009615biological_processresponse to virus
D0009897cellular_componentexternal side of plasma membrane
D0009986cellular_componentcell surface
D0015026molecular_functioncoreceptor activity
D0016477biological_processcell migration
D0016493molecular_functionC-C chemokine receptor activity
D0016494molecular_functionC-X-C chemokine receptor activity
D0019722biological_processcalcium-mediated signaling
D0019957molecular_functionC-C chemokine binding
D0022008biological_processneurogenesis
D0030155biological_processregulation of cell adhesion
D0030334biological_processregulation of cell migration
D0030335biological_processpositive regulation of cell migration
D0031252cellular_componentcell leading edge
D0031410cellular_componentcytoplasmic vesicle
D0031625molecular_functionubiquitin protein ligase binding
D0032027molecular_functionmyosin light chain binding
D0032991cellular_componentprotein-containing complex
D0038147molecular_functionC-X-C motif chemokine 12 receptor activity
D0038160biological_processCXCL12-activated CXCR4 signaling pathway
D0043130molecular_functionubiquitin binding
D0043217biological_processmyelin maintenance
D0046718biological_processsymbiont entry into host cell
D0048714biological_processpositive regulation of oligodendrocyte differentiation
D0060326biological_processcell chemotaxis
D0070062cellular_componentextracellular exosome
D0070098biological_processchemokine-mediated signaling pathway
D0070161cellular_componentanchoring junction
D0071345biological_processcellular response to cytokine stimulus
D0120162biological_processpositive regulation of cold-induced thermogenesis
D1904018biological_processpositive regulation of vasculature development
D2000448biological_processpositive regulation of macrophage migration inhibitory factor signaling pathway
F0001666biological_processresponse to hypoxia
F0001764biological_processneuron migration
F0001938biological_processpositive regulation of endothelial cell proliferation
F0005102molecular_functionsignaling receptor binding
F0005125molecular_functioncytokine activity
F0005178molecular_functionintegrin binding
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005615cellular_componentextracellular space
F0006874biological_processintracellular calcium ion homeostasis
F0006935biological_processchemotaxis
F0006955biological_processimmune response
F0007155biological_processcell adhesion
F0007165biological_processsignal transduction
F0007186biological_processG protein-coupled receptor signaling pathway
F0007411biological_processaxon guidance
F0008009molecular_functionchemokine activity
F0008015biological_processblood circulation
F0008064biological_processregulation of actin polymerization or depolymerization
F0008083molecular_functiongrowth factor activity
F0008284biological_processpositive regulation of cell population proliferation
F0008344biological_processadult locomotory behavior
F0009612biological_processresponse to mechanical stimulus
F0009615biological_processresponse to virus
F0009897cellular_componentexternal side of plasma membrane
F0016020cellular_componentmembrane
F0022029biological_processtelencephalon cell migration
F0030335biological_processpositive regulation of cell migration
F0031012cellular_componentextracellular matrix
F0031100biological_processanimal organ regeneration
F0033603biological_processpositive regulation of dopamine secretion
F0033622biological_processintegrin activation
F0038146biological_processchemokine (C-X-C motif) ligand 12 signaling pathway
F0038160biological_processCXCL12-activated CXCR4 signaling pathway
F0042379molecular_functionchemokine receptor binding
F0043434biological_processresponse to peptide hormone
F0045236molecular_functionCXCR chemokine receptor binding
F0045666biological_processpositive regulation of neuron differentiation
F0045785biological_processpositive regulation of cell adhesion
F0048842biological_processpositive regulation of axon extension involved in axon guidance
F0050921biological_processpositive regulation of chemotaxis
F0050930biological_processinduction of positive chemotaxis
F0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
F0050966biological_processdetection of mechanical stimulus involved in sensory perception of pain
F0051924biological_processregulation of calcium ion transport
F0060326biological_processcell chemotaxis
F0070062cellular_componentextracellular exosome
F0070098biological_processchemokine-mediated signaling pathway
F0090026biological_processpositive regulation of monocyte chemotaxis
F0090280biological_processpositive regulation of calcium ion import
F1902230biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
F1903237biological_processnegative regulation of leukocyte tethering or rolling
F1904018biological_processpositive regulation of vasculature development
F1990478biological_processresponse to ultrasound
F1990869biological_processcellular response to chemokine
F2000406biological_processpositive regulation of T cell migration
F2000669biological_processnegative regulation of dendritic cell apoptotic process
G0001666biological_processresponse to hypoxia
G0001764biological_processneuron migration
G0001938biological_processpositive regulation of endothelial cell proliferation
G0005102molecular_functionsignaling receptor binding
G0005125molecular_functioncytokine activity
G0005178molecular_functionintegrin binding
G0005515molecular_functionprotein binding
G0005576cellular_componentextracellular region
G0005615cellular_componentextracellular space
G0006874biological_processintracellular calcium ion homeostasis
G0006935biological_processchemotaxis
G0006955biological_processimmune response
G0007155biological_processcell adhesion
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0007411biological_processaxon guidance
G0008009molecular_functionchemokine activity
G0008015biological_processblood circulation
G0008064biological_processregulation of actin polymerization or depolymerization
G0008083molecular_functiongrowth factor activity
G0008284biological_processpositive regulation of cell population proliferation
G0008344biological_processadult locomotory behavior
G0009612biological_processresponse to mechanical stimulus
G0009615biological_processresponse to virus
G0009897cellular_componentexternal side of plasma membrane
G0016020cellular_componentmembrane
G0022029biological_processtelencephalon cell migration
G0030335biological_processpositive regulation of cell migration
G0031012cellular_componentextracellular matrix
G0031100biological_processanimal organ regeneration
G0033603biological_processpositive regulation of dopamine secretion
G0033622biological_processintegrin activation
G0038146biological_processchemokine (C-X-C motif) ligand 12 signaling pathway
G0038160biological_processCXCL12-activated CXCR4 signaling pathway
G0042379molecular_functionchemokine receptor binding
G0043434biological_processresponse to peptide hormone
G0045236molecular_functionCXCR chemokine receptor binding
G0045666biological_processpositive regulation of neuron differentiation
G0045785biological_processpositive regulation of cell adhesion
G0048842biological_processpositive regulation of axon extension involved in axon guidance
G0050921biological_processpositive regulation of chemotaxis
G0050930biological_processinduction of positive chemotaxis
G0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
G0050966biological_processdetection of mechanical stimulus involved in sensory perception of pain
G0051924biological_processregulation of calcium ion transport
G0060326biological_processcell chemotaxis
G0070062cellular_componentextracellular exosome
G0070098biological_processchemokine-mediated signaling pathway
G0090026biological_processpositive regulation of monocyte chemotaxis
G0090280biological_processpositive regulation of calcium ion import
G1902230biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
G1903237biological_processnegative regulation of leukocyte tethering or rolling
G1904018biological_processpositive regulation of vasculature development
G1990478biological_processresponse to ultrasound
G1990869biological_processcellular response to chemokine
G2000406biological_processpositive regulation of T cell migration
G2000669biological_processnegative regulation of dendritic cell apoptotic process
H0001666biological_processresponse to hypoxia
H0001764biological_processneuron migration
H0001938biological_processpositive regulation of endothelial cell proliferation
H0005102molecular_functionsignaling receptor binding
H0005125molecular_functioncytokine activity
H0005178molecular_functionintegrin binding
H0005515molecular_functionprotein binding
H0005576cellular_componentextracellular region
H0005615cellular_componentextracellular space
H0006874biological_processintracellular calcium ion homeostasis
H0006935biological_processchemotaxis
H0006955biological_processimmune response
H0007155biological_processcell adhesion
H0007165biological_processsignal transduction
H0007186biological_processG protein-coupled receptor signaling pathway
H0007411biological_processaxon guidance
H0008009molecular_functionchemokine activity
H0008015biological_processblood circulation
H0008064biological_processregulation of actin polymerization or depolymerization
H0008083molecular_functiongrowth factor activity
H0008284biological_processpositive regulation of cell population proliferation
H0008344biological_processadult locomotory behavior
H0009612biological_processresponse to mechanical stimulus
H0009615biological_processresponse to virus
H0009897cellular_componentexternal side of plasma membrane
H0016020cellular_componentmembrane
H0022029biological_processtelencephalon cell migration
H0030335biological_processpositive regulation of cell migration
H0031012cellular_componentextracellular matrix
H0031100biological_processanimal organ regeneration
H0033603biological_processpositive regulation of dopamine secretion
H0033622biological_processintegrin activation
H0038146biological_processchemokine (C-X-C motif) ligand 12 signaling pathway
H0038160biological_processCXCL12-activated CXCR4 signaling pathway
H0042379molecular_functionchemokine receptor binding
H0043434biological_processresponse to peptide hormone
H0045236molecular_functionCXCR chemokine receptor binding
H0045666biological_processpositive regulation of neuron differentiation
H0045785biological_processpositive regulation of cell adhesion
H0048842biological_processpositive regulation of axon extension involved in axon guidance
H0050921biological_processpositive regulation of chemotaxis
H0050930biological_processinduction of positive chemotaxis
H0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
H0050966biological_processdetection of mechanical stimulus involved in sensory perception of pain
H0051924biological_processregulation of calcium ion transport
H0060326biological_processcell chemotaxis
H0070062cellular_componentextracellular exosome
H0070098biological_processchemokine-mediated signaling pathway
H0090026biological_processpositive regulation of monocyte chemotaxis
H0090280biological_processpositive regulation of calcium ion import
H1902230biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
H1903237biological_processnegative regulation of leukocyte tethering or rolling
H1904018biological_processpositive regulation of vasculature development
H1990478biological_processresponse to ultrasound
H1990869biological_processcellular response to chemokine
H2000406biological_processpositive regulation of T cell migration
H2000669biological_processnegative regulation of dendritic cell apoptotic process
J0001666biological_processresponse to hypoxia
J0001764biological_processneuron migration
J0001938biological_processpositive regulation of endothelial cell proliferation
J0005102molecular_functionsignaling receptor binding
J0005125molecular_functioncytokine activity
J0005178molecular_functionintegrin binding
J0005515molecular_functionprotein binding
J0005576cellular_componentextracellular region
J0005615cellular_componentextracellular space
J0006874biological_processintracellular calcium ion homeostasis
J0006935biological_processchemotaxis
J0006955biological_processimmune response
J0007155biological_processcell adhesion
J0007165biological_processsignal transduction
J0007186biological_processG protein-coupled receptor signaling pathway
J0007411biological_processaxon guidance
J0008009molecular_functionchemokine activity
J0008015biological_processblood circulation
J0008064biological_processregulation of actin polymerization or depolymerization
J0008083molecular_functiongrowth factor activity
J0008284biological_processpositive regulation of cell population proliferation
J0008344biological_processadult locomotory behavior
J0009612biological_processresponse to mechanical stimulus
J0009615biological_processresponse to virus
J0009897cellular_componentexternal side of plasma membrane
J0016020cellular_componentmembrane
J0022029biological_processtelencephalon cell migration
J0030335biological_processpositive regulation of cell migration
J0031012cellular_componentextracellular matrix
J0031100biological_processanimal organ regeneration
J0033603biological_processpositive regulation of dopamine secretion
J0033622biological_processintegrin activation
J0038146biological_processchemokine (C-X-C motif) ligand 12 signaling pathway
J0038160biological_processCXCL12-activated CXCR4 signaling pathway
J0042379molecular_functionchemokine receptor binding
J0043434biological_processresponse to peptide hormone
J0045236molecular_functionCXCR chemokine receptor binding
J0045666biological_processpositive regulation of neuron differentiation
J0045785biological_processpositive regulation of cell adhesion
J0048842biological_processpositive regulation of axon extension involved in axon guidance
J0050921biological_processpositive regulation of chemotaxis
J0050930biological_processinduction of positive chemotaxis
J0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
J0050966biological_processdetection of mechanical stimulus involved in sensory perception of pain
J0051924biological_processregulation of calcium ion transport
J0060326biological_processcell chemotaxis
J0070062cellular_componentextracellular exosome
J0070098biological_processchemokine-mediated signaling pathway
J0090026biological_processpositive regulation of monocyte chemotaxis
J0090280biological_processpositive regulation of calcium ion import
J1902230biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
J1903237biological_processnegative regulation of leukocyte tethering or rolling
J1904018biological_processpositive regulation of vasculature development
J1990478biological_processresponse to ultrasound
J1990869biological_processcellular response to chemokine
J2000406biological_processpositive regulation of T cell migration
J2000669biological_processnegative regulation of dendritic cell apoptotic process
M0001666biological_processresponse to hypoxia
M0001764biological_processneuron migration
M0001938biological_processpositive regulation of endothelial cell proliferation
M0005102molecular_functionsignaling receptor binding
M0005125molecular_functioncytokine activity
M0005178molecular_functionintegrin binding
M0005515molecular_functionprotein binding
M0005576cellular_componentextracellular region
M0005615cellular_componentextracellular space
M0006874biological_processintracellular calcium ion homeostasis
M0006935biological_processchemotaxis
M0006955biological_processimmune response
M0007155biological_processcell adhesion
M0007165biological_processsignal transduction
M0007186biological_processG protein-coupled receptor signaling pathway
M0007411biological_processaxon guidance
M0008009molecular_functionchemokine activity
M0008015biological_processblood circulation
M0008064biological_processregulation of actin polymerization or depolymerization
M0008083molecular_functiongrowth factor activity
M0008284biological_processpositive regulation of cell population proliferation
M0008344biological_processadult locomotory behavior
M0009612biological_processresponse to mechanical stimulus
M0009615biological_processresponse to virus
M0009897cellular_componentexternal side of plasma membrane
M0016020cellular_componentmembrane
M0022029biological_processtelencephalon cell migration
M0030335biological_processpositive regulation of cell migration
M0031012cellular_componentextracellular matrix
M0031100biological_processanimal organ regeneration
M0033603biological_processpositive regulation of dopamine secretion
M0033622biological_processintegrin activation
M0038146biological_processchemokine (C-X-C motif) ligand 12 signaling pathway
M0038160biological_processCXCL12-activated CXCR4 signaling pathway
M0042379molecular_functionchemokine receptor binding
M0043434biological_processresponse to peptide hormone
M0045236molecular_functionCXCR chemokine receptor binding
M0045666biological_processpositive regulation of neuron differentiation
M0045785biological_processpositive regulation of cell adhesion
M0048842biological_processpositive regulation of axon extension involved in axon guidance
M0050921biological_processpositive regulation of chemotaxis
M0050930biological_processinduction of positive chemotaxis
M0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
M0050966biological_processdetection of mechanical stimulus involved in sensory perception of pain
M0051924biological_processregulation of calcium ion transport
M0060326biological_processcell chemotaxis
M0070062cellular_componentextracellular exosome
M0070098biological_processchemokine-mediated signaling pathway
M0090026biological_processpositive regulation of monocyte chemotaxis
M0090280biological_processpositive regulation of calcium ion import
M1902230biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
M1903237biological_processnegative regulation of leukocyte tethering or rolling
M1904018biological_processpositive regulation of vasculature development
M1990478biological_processresponse to ultrasound
M1990869biological_processcellular response to chemokine
M2000406biological_processpositive regulation of T cell migration
M2000669biological_processnegative regulation of dendritic cell apoptotic process
N0001666biological_processresponse to hypoxia
N0001764biological_processneuron migration
N0001938biological_processpositive regulation of endothelial cell proliferation
N0005102molecular_functionsignaling receptor binding
N0005125molecular_functioncytokine activity
N0005178molecular_functionintegrin binding
N0005515molecular_functionprotein binding
N0005576cellular_componentextracellular region
N0005615cellular_componentextracellular space
N0006874biological_processintracellular calcium ion homeostasis
N0006935biological_processchemotaxis
N0006955biological_processimmune response
N0007155biological_processcell adhesion
N0007165biological_processsignal transduction
N0007186biological_processG protein-coupled receptor signaling pathway
N0007411biological_processaxon guidance
N0008009molecular_functionchemokine activity
N0008015biological_processblood circulation
N0008064biological_processregulation of actin polymerization or depolymerization
N0008083molecular_functiongrowth factor activity
N0008284biological_processpositive regulation of cell population proliferation
N0008344biological_processadult locomotory behavior
N0009612biological_processresponse to mechanical stimulus
N0009615biological_processresponse to virus
N0009897cellular_componentexternal side of plasma membrane
N0016020cellular_componentmembrane
N0022029biological_processtelencephalon cell migration
N0030335biological_processpositive regulation of cell migration
N0031012cellular_componentextracellular matrix
N0031100biological_processanimal organ regeneration
N0033603biological_processpositive regulation of dopamine secretion
N0033622biological_processintegrin activation
N0038146biological_processchemokine (C-X-C motif) ligand 12 signaling pathway
N0038160biological_processCXCL12-activated CXCR4 signaling pathway
N0042379molecular_functionchemokine receptor binding
N0043434biological_processresponse to peptide hormone
N0045236molecular_functionCXCR chemokine receptor binding
N0045666biological_processpositive regulation of neuron differentiation
N0045785biological_processpositive regulation of cell adhesion
N0048842biological_processpositive regulation of axon extension involved in axon guidance
N0050921biological_processpositive regulation of chemotaxis
N0050930biological_processinduction of positive chemotaxis
N0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
N0050966biological_processdetection of mechanical stimulus involved in sensory perception of pain
N0051924biological_processregulation of calcium ion transport
N0060326biological_processcell chemotaxis
N0070062cellular_componentextracellular exosome
N0070098biological_processchemokine-mediated signaling pathway
N0090026biological_processpositive regulation of monocyte chemotaxis
N0090280biological_processpositive regulation of calcium ion import
N1902230biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
N1903237biological_processnegative regulation of leukocyte tethering or rolling
N1904018biological_processpositive regulation of vasculature development
N1990478biological_processresponse to ultrasound
N1990869biological_processcellular response to chemokine
N2000406biological_processpositive regulation of T cell migration
N2000669biological_processnegative regulation of dendritic cell apoptotic process
O0001666biological_processresponse to hypoxia
O0001764biological_processneuron migration
O0001938biological_processpositive regulation of endothelial cell proliferation
O0005102molecular_functionsignaling receptor binding
O0005125molecular_functioncytokine activity
O0005178molecular_functionintegrin binding
O0005515molecular_functionprotein binding
O0005576cellular_componentextracellular region
O0005615cellular_componentextracellular space
O0006874biological_processintracellular calcium ion homeostasis
O0006935biological_processchemotaxis
O0006955biological_processimmune response
O0007155biological_processcell adhesion
O0007165biological_processsignal transduction
O0007186biological_processG protein-coupled receptor signaling pathway
O0007411biological_processaxon guidance
O0008009molecular_functionchemokine activity
O0008015biological_processblood circulation
O0008064biological_processregulation of actin polymerization or depolymerization
O0008083molecular_functiongrowth factor activity
O0008284biological_processpositive regulation of cell population proliferation
O0008344biological_processadult locomotory behavior
O0009612biological_processresponse to mechanical stimulus
O0009615biological_processresponse to virus
O0009897cellular_componentexternal side of plasma membrane
O0016020cellular_componentmembrane
O0022029biological_processtelencephalon cell migration
O0030335biological_processpositive regulation of cell migration
O0031012cellular_componentextracellular matrix
O0031100biological_processanimal organ regeneration
O0033603biological_processpositive regulation of dopamine secretion
O0033622biological_processintegrin activation
O0038146biological_processchemokine (C-X-C motif) ligand 12 signaling pathway
O0038160biological_processCXCL12-activated CXCR4 signaling pathway
O0042379molecular_functionchemokine receptor binding
O0043434biological_processresponse to peptide hormone
O0045236molecular_functionCXCR chemokine receptor binding
O0045666biological_processpositive regulation of neuron differentiation
O0045785biological_processpositive regulation of cell adhesion
O0048842biological_processpositive regulation of axon extension involved in axon guidance
O0050921biological_processpositive regulation of chemotaxis
O0050930biological_processinduction of positive chemotaxis
O0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
O0050966biological_processdetection of mechanical stimulus involved in sensory perception of pain
O0051924biological_processregulation of calcium ion transport
O0060326biological_processcell chemotaxis
O0070062cellular_componentextracellular exosome
O0070098biological_processchemokine-mediated signaling pathway
O0090026biological_processpositive regulation of monocyte chemotaxis
O0090280biological_processpositive regulation of calcium ion import
O1902230biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
O1903237biological_processnegative regulation of leukocyte tethering or rolling
O1904018biological_processpositive regulation of vasculature development
O1990478biological_processresponse to ultrasound
O1990869biological_processcellular response to chemokine
O2000406biological_processpositive regulation of T cell migration
O2000669biological_processnegative regulation of dendritic cell apoptotic process
P0001666biological_processresponse to hypoxia
P0001764biological_processneuron migration
P0001938biological_processpositive regulation of endothelial cell proliferation
P0005102molecular_functionsignaling receptor binding
P0005125molecular_functioncytokine activity
P0005178molecular_functionintegrin binding
P0005515molecular_functionprotein binding
P0005576cellular_componentextracellular region
P0005615cellular_componentextracellular space
P0006874biological_processintracellular calcium ion homeostasis
P0006935biological_processchemotaxis
P0006955biological_processimmune response
P0007155biological_processcell adhesion
P0007165biological_processsignal transduction
P0007186biological_processG protein-coupled receptor signaling pathway
P0007411biological_processaxon guidance
P0008009molecular_functionchemokine activity
P0008015biological_processblood circulation
P0008064biological_processregulation of actin polymerization or depolymerization
P0008083molecular_functiongrowth factor activity
P0008284biological_processpositive regulation of cell population proliferation
P0008344biological_processadult locomotory behavior
P0009612biological_processresponse to mechanical stimulus
P0009615biological_processresponse to virus
P0009897cellular_componentexternal side of plasma membrane
P0016020cellular_componentmembrane
P0022029biological_processtelencephalon cell migration
P0030335biological_processpositive regulation of cell migration
P0031012cellular_componentextracellular matrix
P0031100biological_processanimal organ regeneration
P0033603biological_processpositive regulation of dopamine secretion
P0033622biological_processintegrin activation
P0038146biological_processchemokine (C-X-C motif) ligand 12 signaling pathway
P0038160biological_processCXCL12-activated CXCR4 signaling pathway
P0042379molecular_functionchemokine receptor binding
P0043434biological_processresponse to peptide hormone
P0045236molecular_functionCXCR chemokine receptor binding
P0045666biological_processpositive regulation of neuron differentiation
P0045785biological_processpositive regulation of cell adhesion
P0048842biological_processpositive regulation of axon extension involved in axon guidance
P0050921biological_processpositive regulation of chemotaxis
P0050930biological_processinduction of positive chemotaxis
P0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
P0050966biological_processdetection of mechanical stimulus involved in sensory perception of pain
P0051924biological_processregulation of calcium ion transport
P0060326biological_processcell chemotaxis
P0070062cellular_componentextracellular exosome
P0070098biological_processchemokine-mediated signaling pathway
P0090026biological_processpositive regulation of monocyte chemotaxis
P0090280biological_processpositive regulation of calcium ion import
P1902230biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
P1903237biological_processnegative regulation of leukocyte tethering or rolling
P1904018biological_processpositive regulation of vasculature development
P1990478biological_processresponse to ultrasound
P1990869biological_processcellular response to chemokine
P2000406biological_processpositive regulation of T cell migration
P2000669biological_processnegative regulation of dendritic cell apoptotic process
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SSVlILAFISLDRYLaI
ChainResidueDetails
BSER122-ILE138

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues96
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues240
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues84
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues200
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues76
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues76
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues76
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues76
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues12
DetailsRegion: {"description":"Chemokine binding","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10825158","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues16
DetailsRegion: {"description":"Chemokine binding"}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues48
DetailsRegion: {"description":"Involved in dimerization; when bound to chemokine"}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues16
DetailsRegion: {"description":"Chemokine binding, important for signaling and HIV-1 coreceptor activity"}
ChainResidueDetails

site_idSWS_FT_FI14
Number of Residues84
DetailsRegion: {"description":"Involved in dimerization"}
ChainResidueDetails

site_idSWS_FT_FI15
Number of Residues8
DetailsMotif: {"description":"Important for signaling"}
ChainResidueDetails

site_idSWS_FT_FI16
Number of Residues4
DetailsSite: {"description":"Chemokine binding"}
ChainResidueDetails

site_idSWS_FT_FI17
Number of Residues4
DetailsSite: {"description":"Chemokine binding","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10825158","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI18
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI19
Number of Residues32
DetailsRegion: {"description":"Receptor and heparin binding","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI20
Number of Residues112
DetailsRegion: {"description":"Receptor binding"}
ChainResidueDetails

site_idSWS_FT_FI21
Number of Residues8
DetailsMotif: {"description":"Receptor activation motif"}
ChainResidueDetails

site_idSWS_FT_FI22
Number of Residues104
DetailsBinding site: {}
ChainResidueDetails

site_idSWS_FT_FI23
Number of Residues24
DetailsSite: {"description":"Important for integrin interaction and activation","evidences":[{"source":"PubMed","id":"29301984","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI24
Number of Residues8
DetailsSite: {"description":"Important for dimer formation"}
ChainResidueDetails

248335

PDB entries from 2026-01-28

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