9MET

CXCR4-HIV-2/gp120-CD4

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
M	0001618	molecular_function	virus receptor activity
M	0001666	biological_process	response to hypoxia
M	0002407	biological_process	dendritic cell chemotaxis
M	0003779	molecular_function	actin binding
M	0004930	molecular_function	G protein-coupled receptor activity
M	0005515	molecular_function	protein binding
M	0005737	cellular_component	cytoplasm
M	0005764	cellular_component	lysosome
M	0005769	cellular_component	early endosome
M	0005770	cellular_component	late endosome
M	0005886	cellular_component	plasma membrane
M	0006915	biological_process	apoptotic process
M	0006954	biological_process	inflammatory response
M	0006955	biological_process	immune response
M	0007165	biological_process	signal transduction
M	0007186	biological_process	G protein-coupled receptor signaling pathway
M	0007193	biological_process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
M	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
M	0007420	biological_process	brain development
M	0009615	biological_process	response to virus
M	0009897	cellular_component	external side of plasma membrane
M	0009986	cellular_component	cell surface
M	0015026	molecular_function	coreceptor activity
M	0016477	biological_process	cell migration
M	0016493	molecular_function	C-C chemokine receptor activity
M	0016494	molecular_function	C-X-C chemokine receptor activity
M	0019722	biological_process	calcium-mediated signaling
M	0019957	molecular_function	C-C chemokine binding
M	0022008	biological_process	neurogenesis
M	0030155	biological_process	regulation of cell adhesion
M	0030334	biological_process	regulation of cell migration
M	0030335	biological_process	positive regulation of cell migration
M	0031252	cellular_component	cell leading edge
M	0031410	cellular_component	cytoplasmic vesicle
M	0031625	molecular_function	ubiquitin protein ligase binding
M	0032027	molecular_function	myosin light chain binding
M	0032991	cellular_component	protein-containing complex
M	0038147	molecular_function	C-X-C motif chemokine 12 receptor activity
M	0038160	biological_process	CXCL12-activated CXCR4 signaling pathway
M	0043130	molecular_function	ubiquitin binding
M	0043217	biological_process	myelin maintenance
M	0046718	biological_process	symbiont entry into host cell
M	0048714	biological_process	positive regulation of oligodendrocyte differentiation
M	0060326	biological_process	cell chemotaxis
M	0070062	cellular_component	extracellular exosome
M	0070098	biological_process	chemokine-mediated signaling pathway
M	0070161	cellular_component	anchoring junction
M	0071345	biological_process	cellular response to cytokine stimulus
M	0120162	biological_process	positive regulation of cold-induced thermogenesis
M	1904018	biological_process	positive regulation of vasculature development
M	2000448	biological_process	positive regulation of macrophage migration inhibitory factor signaling pathway
N	0001618	molecular_function	virus receptor activity
N	0001666	biological_process	response to hypoxia
N	0002407	biological_process	dendritic cell chemotaxis
N	0003779	molecular_function	actin binding
N	0004930	molecular_function	G protein-coupled receptor activity
N	0005515	molecular_function	protein binding
N	0005737	cellular_component	cytoplasm
N	0005764	cellular_component	lysosome
N	0005769	cellular_component	early endosome
N	0005770	cellular_component	late endosome
N	0005886	cellular_component	plasma membrane
N	0006915	biological_process	apoptotic process
N	0006954	biological_process	inflammatory response
N	0006955	biological_process	immune response
N	0007165	biological_process	signal transduction
N	0007186	biological_process	G protein-coupled receptor signaling pathway
N	0007193	biological_process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
N	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
N	0007420	biological_process	brain development
N	0009615	biological_process	response to virus
N	0009897	cellular_component	external side of plasma membrane
N	0009986	cellular_component	cell surface
N	0015026	molecular_function	coreceptor activity
N	0016477	biological_process	cell migration
N	0016493	molecular_function	C-C chemokine receptor activity
N	0016494	molecular_function	C-X-C chemokine receptor activity
N	0019722	biological_process	calcium-mediated signaling
N	0019957	molecular_function	C-C chemokine binding
N	0022008	biological_process	neurogenesis
N	0030155	biological_process	regulation of cell adhesion
N	0030334	biological_process	regulation of cell migration
N	0030335	biological_process	positive regulation of cell migration
N	0031252	cellular_component	cell leading edge
N	0031410	cellular_component	cytoplasmic vesicle
N	0031625	molecular_function	ubiquitin protein ligase binding
N	0032027	molecular_function	myosin light chain binding
N	0032991	cellular_component	protein-containing complex
N	0038147	molecular_function	C-X-C motif chemokine 12 receptor activity
N	0038160	biological_process	CXCL12-activated CXCR4 signaling pathway
N	0043130	molecular_function	ubiquitin binding
N	0043217	biological_process	myelin maintenance
N	0046718	biological_process	symbiont entry into host cell
N	0048714	biological_process	positive regulation of oligodendrocyte differentiation
N	0060326	biological_process	cell chemotaxis
N	0070062	cellular_component	extracellular exosome
N	0070098	biological_process	chemokine-mediated signaling pathway
N	0070161	cellular_component	anchoring junction
N	0071345	biological_process	cellular response to cytokine stimulus
N	0120162	biological_process	positive regulation of cold-induced thermogenesis
N	1904018	biological_process	positive regulation of vasculature development
N	2000448	biological_process	positive regulation of macrophage migration inhibitory factor signaling pathway
O	0001618	molecular_function	virus receptor activity
O	0001666	biological_process	response to hypoxia
O	0002407	biological_process	dendritic cell chemotaxis
O	0003779	molecular_function	actin binding
O	0004930	molecular_function	G protein-coupled receptor activity
O	0005515	molecular_function	protein binding
O	0005737	cellular_component	cytoplasm
O	0005764	cellular_component	lysosome
O	0005769	cellular_component	early endosome
O	0005770	cellular_component	late endosome
O	0005886	cellular_component	plasma membrane
O	0006915	biological_process	apoptotic process
O	0006954	biological_process	inflammatory response
O	0006955	biological_process	immune response
O	0007165	biological_process	signal transduction
O	0007186	biological_process	G protein-coupled receptor signaling pathway
O	0007193	biological_process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
O	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
O	0007420	biological_process	brain development
O	0009615	biological_process	response to virus
O	0009897	cellular_component	external side of plasma membrane
O	0009986	cellular_component	cell surface
O	0015026	molecular_function	coreceptor activity
O	0016477	biological_process	cell migration
O	0016493	molecular_function	C-C chemokine receptor activity
O	0016494	molecular_function	C-X-C chemokine receptor activity
O	0019722	biological_process	calcium-mediated signaling
O	0019957	molecular_function	C-C chemokine binding
O	0022008	biological_process	neurogenesis
O	0030155	biological_process	regulation of cell adhesion
O	0030334	biological_process	regulation of cell migration
O	0030335	biological_process	positive regulation of cell migration
O	0031252	cellular_component	cell leading edge
O	0031410	cellular_component	cytoplasmic vesicle
O	0031625	molecular_function	ubiquitin protein ligase binding
O	0032027	molecular_function	myosin light chain binding
O	0032991	cellular_component	protein-containing complex
O	0038147	molecular_function	C-X-C motif chemokine 12 receptor activity
O	0038160	biological_process	CXCL12-activated CXCR4 signaling pathway
O	0043130	molecular_function	ubiquitin binding
O	0043217	biological_process	myelin maintenance
O	0046718	biological_process	symbiont entry into host cell
O	0048714	biological_process	positive regulation of oligodendrocyte differentiation
O	0060326	biological_process	cell chemotaxis
O	0070062	cellular_component	extracellular exosome
O	0070098	biological_process	chemokine-mediated signaling pathway
O	0070161	cellular_component	anchoring junction
O	0071345	biological_process	cellular response to cytokine stimulus
O	0120162	biological_process	positive regulation of cold-induced thermogenesis
O	1904018	biological_process	positive regulation of vasculature development
O	2000448	biological_process	positive regulation of macrophage migration inhibitory factor signaling pathway
S	0001618	molecular_function	virus receptor activity
S	0001666	biological_process	response to hypoxia
S	0002407	biological_process	dendritic cell chemotaxis
S	0003779	molecular_function	actin binding
S	0004930	molecular_function	G protein-coupled receptor activity
S	0005515	molecular_function	protein binding
S	0005737	cellular_component	cytoplasm
S	0005764	cellular_component	lysosome
S	0005769	cellular_component	early endosome
S	0005770	cellular_component	late endosome
S	0005886	cellular_component	plasma membrane
S	0006915	biological_process	apoptotic process
S	0006954	biological_process	inflammatory response
S	0006955	biological_process	immune response
S	0007165	biological_process	signal transduction
S	0007186	biological_process	G protein-coupled receptor signaling pathway
S	0007193	biological_process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
S	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
S	0007420	biological_process	brain development
S	0009615	biological_process	response to virus
S	0009897	cellular_component	external side of plasma membrane
S	0009986	cellular_component	cell surface
S	0015026	molecular_function	coreceptor activity
S	0016477	biological_process	cell migration
S	0016493	molecular_function	C-C chemokine receptor activity
S	0016494	molecular_function	C-X-C chemokine receptor activity
S	0019722	biological_process	calcium-mediated signaling
S	0019957	molecular_function	C-C chemokine binding
S	0022008	biological_process	neurogenesis
S	0030155	biological_process	regulation of cell adhesion
S	0030334	biological_process	regulation of cell migration
S	0030335	biological_process	positive regulation of cell migration
S	0031252	cellular_component	cell leading edge
S	0031410	cellular_component	cytoplasmic vesicle
S	0031625	molecular_function	ubiquitin protein ligase binding
S	0032027	molecular_function	myosin light chain binding
S	0032991	cellular_component	protein-containing complex
S	0038147	molecular_function	C-X-C motif chemokine 12 receptor activity
S	0038160	biological_process	CXCL12-activated CXCR4 signaling pathway
S	0043130	molecular_function	ubiquitin binding
S	0043217	biological_process	myelin maintenance
S	0046718	biological_process	symbiont entry into host cell
S	0048714	biological_process	positive regulation of oligodendrocyte differentiation
S	0060326	biological_process	cell chemotaxis
S	0070062	cellular_component	extracellular exosome
S	0070098	biological_process	chemokine-mediated signaling pathway
S	0070161	cellular_component	anchoring junction
S	0071345	biological_process	cellular response to cytokine stimulus
S	0120162	biological_process	positive regulation of cold-induced thermogenesis
S	1904018	biological_process	positive regulation of vasculature development
S	2000448	biological_process	positive regulation of macrophage migration inhibitory factor signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SSVlILAFISLDRYLaI

Chain	Residue	Details
M	SER122-ILE138

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	96
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	240
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	84
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	200
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	76
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	76
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	76
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	76
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	12
Details	Region: {"description":"Chemokine binding","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10825158","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	16
Details	Region: {"description":"Chemokine binding"}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	48
Details	Region: {"description":"Involved in dimerization; when bound to chemokine"}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	16
Details	Region: {"description":"Chemokine binding, important for signaling and HIV-1 coreceptor activity"}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	84
Details	Region: {"description":"Involved in dimerization"}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	8
Details	Motif: {"description":"Important for signaling"}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	4
Details	Site: {"description":"Chemokine binding"}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	4
Details	Site: {"description":"Chemokine binding","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10825158","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	198
Details	Domain: {"description":"Ig-like V-type"}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	82
Details	Region: {"description":"V2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	46
Details	Region: {"description":"V4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	10
Details	Region: {"description":"V5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	48
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; by host","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---