9MEL
Structure of the human TWIK-2 potassium channel in complex with pimozide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005242 | molecular_function | inward rectifier potassium channel activity |
| A | 0005267 | molecular_function | potassium channel activity |
| A | 0005765 | cellular_component | lysosomal membrane |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0008076 | cellular_component | voltage-gated potassium channel complex |
| A | 0015271 | molecular_function | outward rectifier potassium channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0022841 | molecular_function | potassium ion leak channel activity |
| A | 0031902 | cellular_component | late endosome membrane |
| A | 0062196 | biological_process | regulation of lysosome size |
| A | 0071805 | biological_process | potassium ion transmembrane transport |
| A | 1900227 | biological_process | positive regulation of NLRP3 inflammasome complex assembly |
| B | 0005242 | molecular_function | inward rectifier potassium channel activity |
| B | 0005267 | molecular_function | potassium channel activity |
| B | 0005765 | cellular_component | lysosomal membrane |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006813 | biological_process | potassium ion transport |
| B | 0008076 | cellular_component | voltage-gated potassium channel complex |
| B | 0015271 | molecular_function | outward rectifier potassium channel activity |
| B | 0016020 | cellular_component | membrane |
| B | 0022841 | molecular_function | potassium ion leak channel activity |
| B | 0031902 | cellular_component | late endosome membrane |
| B | 0062196 | biological_process | regulation of lysosome size |
| B | 0071805 | biological_process | potassium ion transmembrane transport |
| B | 1900227 | biological_process | positive regulation of NLRP3 inflammasome complex assembly |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 18 |
| Details | Intramembrane: {"evidences":[{"source":"PubMed","id":"40343992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"41617707","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9E94","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9MEK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9MEL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 52 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"40343992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"41617707","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9E94","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9MEK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9MEL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=M2","evidences":[{"source":"PubMed","id":"40343992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"41617707","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9E94","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9MEK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9MEL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=M3","evidences":[{"source":"PubMed","id":"40343992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"41617707","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9E94","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9MEK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9MEL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 30 |
| Details | Intramembrane: {"description":"Pore-forming; Name=PH2","evidences":[{"source":"PubMed","id":"40343992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"41617707","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9E94","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9MEK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9MEL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=M4","evidences":[{"source":"PubMed","id":"40343992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"41617707","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9E94","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9MEK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9MEL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | Region: {"description":"Selectivity filter 1","evidences":[{"source":"PubMed","id":"40343992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"41617707","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9E94","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9MEK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9MEL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 10 |
| Details | Region: {"description":"Selectivity filter 2","evidences":[{"source":"PubMed","id":"40343992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"41617707","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9E94","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9MEK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9MEL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"40343992","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9MEK","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
