9MDU

Human CXCR4 tetramer

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001618	molecular_function	virus receptor activity
A	0001666	biological_process	response to hypoxia
A	0002407	biological_process	dendritic cell chemotaxis
A	0003779	molecular_function	actin binding
A	0004930	molecular_function	G protein-coupled receptor activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005769	cellular_component	early endosome
A	0005770	cellular_component	late endosome
A	0005886	cellular_component	plasma membrane
A	0006915	biological_process	apoptotic process
A	0006954	biological_process	inflammatory response
A	0006955	biological_process	immune response
A	0007165	biological_process	signal transduction
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0007193	biological_process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
A	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
A	0007420	biological_process	brain development
A	0009615	biological_process	response to virus
A	0009897	cellular_component	external side of plasma membrane
A	0009986	cellular_component	cell surface
A	0015026	molecular_function	coreceptor activity
A	0016477	biological_process	cell migration
A	0016493	molecular_function	C-C chemokine receptor activity
A	0016494	molecular_function	C-X-C chemokine receptor activity
A	0019722	biological_process	calcium-mediated signaling
A	0019957	molecular_function	C-C chemokine binding
A	0022008	biological_process	neurogenesis
A	0030155	biological_process	regulation of cell adhesion
A	0030334	biological_process	regulation of cell migration
A	0030335	biological_process	positive regulation of cell migration
A	0031252	cellular_component	cell leading edge
A	0031410	cellular_component	cytoplasmic vesicle
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0032027	molecular_function	myosin light chain binding
A	0032991	cellular_component	protein-containing complex
A	0038147	molecular_function	C-X-C motif chemokine 12 receptor activity
A	0038160	biological_process	CXCL12-activated CXCR4 signaling pathway
A	0043130	molecular_function	ubiquitin binding
A	0043217	biological_process	myelin maintenance
A	0046718	biological_process	symbiont entry into host cell
A	0048714	biological_process	positive regulation of oligodendrocyte differentiation
A	0060326	biological_process	cell chemotaxis
A	0070062	cellular_component	extracellular exosome
A	0070098	biological_process	chemokine-mediated signaling pathway
A	0070161	cellular_component	anchoring junction
A	0071345	biological_process	cellular response to cytokine stimulus
A	0120162	biological_process	positive regulation of cold-induced thermogenesis
A	1904018	biological_process	positive regulation of vasculature development
A	2000448	biological_process	positive regulation of macrophage migration inhibitory factor signaling pathway
B	0001618	molecular_function	virus receptor activity
B	0001666	biological_process	response to hypoxia
B	0002407	biological_process	dendritic cell chemotaxis
B	0003779	molecular_function	actin binding
B	0004930	molecular_function	G protein-coupled receptor activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005764	cellular_component	lysosome
B	0005769	cellular_component	early endosome
B	0005770	cellular_component	late endosome
B	0005886	cellular_component	plasma membrane
B	0006915	biological_process	apoptotic process
B	0006954	biological_process	inflammatory response
B	0006955	biological_process	immune response
B	0007165	biological_process	signal transduction
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0007193	biological_process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
B	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
B	0007420	biological_process	brain development
B	0009615	biological_process	response to virus
B	0009897	cellular_component	external side of plasma membrane
B	0009986	cellular_component	cell surface
B	0015026	molecular_function	coreceptor activity
B	0016477	biological_process	cell migration
B	0016493	molecular_function	C-C chemokine receptor activity
B	0016494	molecular_function	C-X-C chemokine receptor activity
B	0019722	biological_process	calcium-mediated signaling
B	0019957	molecular_function	C-C chemokine binding
B	0022008	biological_process	neurogenesis
B	0030155	biological_process	regulation of cell adhesion
B	0030334	biological_process	regulation of cell migration
B	0030335	biological_process	positive regulation of cell migration
B	0031252	cellular_component	cell leading edge
B	0031410	cellular_component	cytoplasmic vesicle
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0032027	molecular_function	myosin light chain binding
B	0032991	cellular_component	protein-containing complex
B	0038147	molecular_function	C-X-C motif chemokine 12 receptor activity
B	0038160	biological_process	CXCL12-activated CXCR4 signaling pathway
B	0043130	molecular_function	ubiquitin binding
B	0043217	biological_process	myelin maintenance
B	0046718	biological_process	symbiont entry into host cell
B	0048714	biological_process	positive regulation of oligodendrocyte differentiation
B	0060326	biological_process	cell chemotaxis
B	0070062	cellular_component	extracellular exosome
B	0070098	biological_process	chemokine-mediated signaling pathway
B	0070161	cellular_component	anchoring junction
B	0071345	biological_process	cellular response to cytokine stimulus
B	0120162	biological_process	positive regulation of cold-induced thermogenesis
B	1904018	biological_process	positive regulation of vasculature development
B	2000448	biological_process	positive regulation of macrophage migration inhibitory factor signaling pathway
C	0001618	molecular_function	virus receptor activity
C	0001666	biological_process	response to hypoxia
C	0002407	biological_process	dendritic cell chemotaxis
C	0003779	molecular_function	actin binding
C	0004930	molecular_function	G protein-coupled receptor activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005764	cellular_component	lysosome
C	0005769	cellular_component	early endosome
C	0005770	cellular_component	late endosome
C	0005886	cellular_component	plasma membrane
C	0006915	biological_process	apoptotic process
C	0006954	biological_process	inflammatory response
C	0006955	biological_process	immune response
C	0007165	biological_process	signal transduction
C	0007186	biological_process	G protein-coupled receptor signaling pathway
C	0007193	biological_process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
C	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
C	0007420	biological_process	brain development
C	0009615	biological_process	response to virus
C	0009897	cellular_component	external side of plasma membrane
C	0009986	cellular_component	cell surface
C	0015026	molecular_function	coreceptor activity
C	0016477	biological_process	cell migration
C	0016493	molecular_function	C-C chemokine receptor activity
C	0016494	molecular_function	C-X-C chemokine receptor activity
C	0019722	biological_process	calcium-mediated signaling
C	0019957	molecular_function	C-C chemokine binding
C	0022008	biological_process	neurogenesis
C	0030155	biological_process	regulation of cell adhesion
C	0030334	biological_process	regulation of cell migration
C	0030335	biological_process	positive regulation of cell migration
C	0031252	cellular_component	cell leading edge
C	0031410	cellular_component	cytoplasmic vesicle
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0032027	molecular_function	myosin light chain binding
C	0032991	cellular_component	protein-containing complex
C	0038147	molecular_function	C-X-C motif chemokine 12 receptor activity
C	0038160	biological_process	CXCL12-activated CXCR4 signaling pathway
C	0043130	molecular_function	ubiquitin binding
C	0043217	biological_process	myelin maintenance
C	0046718	biological_process	symbiont entry into host cell
C	0048714	biological_process	positive regulation of oligodendrocyte differentiation
C	0060326	biological_process	cell chemotaxis
C	0070062	cellular_component	extracellular exosome
C	0070098	biological_process	chemokine-mediated signaling pathway
C	0070161	cellular_component	anchoring junction
C	0071345	biological_process	cellular response to cytokine stimulus
C	0120162	biological_process	positive regulation of cold-induced thermogenesis
C	1904018	biological_process	positive regulation of vasculature development
C	2000448	biological_process	positive regulation of macrophage migration inhibitory factor signaling pathway
D	0001618	molecular_function	virus receptor activity
D	0001666	biological_process	response to hypoxia
D	0002407	biological_process	dendritic cell chemotaxis
D	0003779	molecular_function	actin binding
D	0004930	molecular_function	G protein-coupled receptor activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005764	cellular_component	lysosome
D	0005769	cellular_component	early endosome
D	0005770	cellular_component	late endosome
D	0005886	cellular_component	plasma membrane
D	0006915	biological_process	apoptotic process
D	0006954	biological_process	inflammatory response
D	0006955	biological_process	immune response
D	0007165	biological_process	signal transduction
D	0007186	biological_process	G protein-coupled receptor signaling pathway
D	0007193	biological_process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
D	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
D	0007420	biological_process	brain development
D	0009615	biological_process	response to virus
D	0009897	cellular_component	external side of plasma membrane
D	0009986	cellular_component	cell surface
D	0015026	molecular_function	coreceptor activity
D	0016477	biological_process	cell migration
D	0016493	molecular_function	C-C chemokine receptor activity
D	0016494	molecular_function	C-X-C chemokine receptor activity
D	0019722	biological_process	calcium-mediated signaling
D	0019957	molecular_function	C-C chemokine binding
D	0022008	biological_process	neurogenesis
D	0030155	biological_process	regulation of cell adhesion
D	0030334	biological_process	regulation of cell migration
D	0030335	biological_process	positive regulation of cell migration
D	0031252	cellular_component	cell leading edge
D	0031410	cellular_component	cytoplasmic vesicle
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0032027	molecular_function	myosin light chain binding
D	0032991	cellular_component	protein-containing complex
D	0038147	molecular_function	C-X-C motif chemokine 12 receptor activity
D	0038160	biological_process	CXCL12-activated CXCR4 signaling pathway
D	0043130	molecular_function	ubiquitin binding
D	0043217	biological_process	myelin maintenance
D	0046718	biological_process	symbiont entry into host cell
D	0048714	biological_process	positive regulation of oligodendrocyte differentiation
D	0060326	biological_process	cell chemotaxis
D	0070062	cellular_component	extracellular exosome
D	0070098	biological_process	chemokine-mediated signaling pathway
D	0070161	cellular_component	anchoring junction
D	0071345	biological_process	cellular response to cytokine stimulus
D	0120162	biological_process	positive regulation of cold-induced thermogenesis
D	1904018	biological_process	positive regulation of vasculature development
D	2000448	biological_process	positive regulation of macrophage migration inhibitory factor signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SSVlILAFISLDRYLaI

Chain	Residue	Details
B	SER122-ILE138

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	96
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	240
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	84
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	200
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	76
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	76
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	76
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	76
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	12
Details	Region: {"description":"Chemokine binding","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10825158","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	16
Details	Region: {"description":"Chemokine binding"}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	48
Details	Region: {"description":"Involved in dimerization; when bound to chemokine"}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	16
Details	Region: {"description":"Chemokine binding, important for signaling and HIV-1 coreceptor activity"}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	84
Details	Region: {"description":"Involved in dimerization"}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	8
Details	Motif: {"description":"Important for signaling"}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	4
Details	Site: {"description":"Chemokine binding"}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	4
Details	Site: {"description":"Chemokine binding","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10825158","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---