9MC8

Cryo-EM structure of human OAT1 in complex with PAH

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005452	molecular_function	solute:inorganic anion antiporter activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0005901	cellular_component	caveola
A	0006820	biological_process	monoatomic anion transport
A	0008514	molecular_function	obsolete organic anion transmembrane transporter activity
A	0009925	cellular_component	basal plasma membrane
A	0015132	molecular_function	prostaglandin transmembrane transporter activity
A	0015139	molecular_function	alpha-ketoglutarate transmembrane transporter activity
A	0015297	molecular_function	antiporter activity
A	0015347	molecular_function	obsolete sodium-independent organic anion transmembrane transporter activity
A	0015698	biological_process	inorganic anion transport
A	0015711	biological_process	organic anion transport
A	0015732	biological_process	prostaglandin transport
A	0015742	biological_process	alpha-ketoglutarate transport
A	0016323	cellular_component	basolateral plasma membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0031404	molecular_function	chloride ion binding
A	0032991	cellular_component	protein-containing complex
A	0042802	molecular_function	identical protein binding
A	0042908	biological_process	xenobiotic transport
A	0042910	molecular_function	xenobiotic transmembrane transporter activity
A	0043252	biological_process	sodium-independent organic anion transport
A	0070062	cellular_component	extracellular exosome
A	0072237	biological_process	metanephric proximal tubule development
A	0097254	biological_process	renal tubular secretion

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	243
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	30
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	29
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Important for interaction with cidofovir"}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Site: {"description":"Important for interaction with cidofovir and PAH"}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14749323","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"10462545","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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