9MBO
Focused refinement of RPN1 and the C-terminal helix of midnolin in the substrate-engaged human 26S proteasome
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005730 | cellular_component | nucleolus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0010499 | biological_process | proteasomal ubiquitin-independent protein catabolic process |
| A | 0019900 | molecular_function | kinase binding |
| A | 0033132 | biological_process | negative regulation of glucokinase activity |
| A | 0046676 | biological_process | negative regulation of insulin secretion |
| A | 0060090 | molecular_function | molecular adaptor activity |
| B | 0000502 | cellular_component | proteasome complex |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005838 | cellular_component | proteasome regulatory particle |
| B | 0006979 | biological_process | response to oxidative stress |
| B | 0008021 | cellular_component | synaptic vesicle |
| B | 0010498 | biological_process | proteasomal protein catabolic process |
| B | 0016020 | cellular_component | membrane |
| B | 0022624 | cellular_component | proteasome accessory complex |
| B | 0034515 | cellular_component | proteasome storage granule |
| B | 0034774 | cellular_component | secretory granule lumen |
| B | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
| B | 0061136 | biological_process | regulation of proteasomal protein catabolic process |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0071357 | biological_process | cellular response to type I interferon |
| B | 1904813 | cellular_component | ficolin-1-rich granule lumen |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"PC 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 36 |
| Details | Repeat: {"description":"PC 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 34 |
| Details | Repeat: {"description":"PC 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 34 |
| Details | Repeat: {"description":"PC 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 29 |
| Details | Repeat: {"description":"PC 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 31 |
| Details | Repeat: {"description":"PC 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 15 |
| Details | Repeat: {"description":"PC 7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 195 |
| Details | Region: {"description":"Required for interaction with UBLCP1","evidences":[{"source":"PubMed","id":"28539385","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"17323924","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q8VDM4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
