Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9MBA

Cryo-EM structure of complex of transducer-bound GPCR

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000139	cellular_component	Golgi membrane
B	0000785	cellular_component	chromatin
B	0001664	molecular_function	G protein-coupled receptor binding
B	0001678	biological_process	intracellular glucose homeostasis
B	0001934	biological_process	positive regulation of protein phosphorylation
B	0002029	biological_process	desensitization of G protein-coupled receptor signaling pathway
B	0002031	biological_process	G protein-coupled receptor internalization
B	0002092	biological_process	positive regulation of receptor internalization
B	0003713	molecular_function	transcription coactivator activity
B	0004402	molecular_function	histone acetyltransferase activity
B	0004857	molecular_function	enzyme inhibitor activity
B	0005096	molecular_function	GTPase activator activity
B	0005159	molecular_function	insulin-like growth factor receptor binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005765	cellular_component	lysosomal membrane
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005905	cellular_component	clathrin-coated pit
B	0006351	biological_process	DNA-templated transcription
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0007166	biological_process	cell surface receptor signaling pathway
B	0007600	biological_process	sensory perception
B	0009968	biological_process	negative regulation of signal transduction
B	0010613	biological_process	positive regulation of cardiac muscle hypertrophy
B	0015031	biological_process	protein transport
B	0016567	biological_process	protein ubiquitination
B	0019899	molecular_function	enzyme binding
B	0030659	cellular_component	cytoplasmic vesicle membrane
B	0030666	cellular_component	endocytic vesicle membrane
B	0031143	cellular_component	pseudopodium
B	0031397	biological_process	negative regulation of protein ubiquitination
B	0031410	cellular_component	cytoplasmic vesicle
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0031701	molecular_function	angiotensin receptor binding
B	0032715	biological_process	negative regulation of interleukin-6 production
B	0032717	biological_process	negative regulation of interleukin-8 production
B	0035025	biological_process	positive regulation of Rho protein signal transduction
B	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
B	0043149	biological_process	stress fiber assembly
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0045746	biological_process	negative regulation of Notch signaling pathway
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0060090	molecular_function	molecular adaptor activity
B	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
B	1902533	biological_process	positive regulation of intracellular signal transduction
B	1990763	molecular_function	arrestin family protein binding
C	0000139	cellular_component	Golgi membrane
C	0000785	cellular_component	chromatin
C	0001664	molecular_function	G protein-coupled receptor binding
C	0001678	biological_process	intracellular glucose homeostasis
C	0001934	biological_process	positive regulation of protein phosphorylation
C	0002029	biological_process	desensitization of G protein-coupled receptor signaling pathway
C	0002031	biological_process	G protein-coupled receptor internalization
C	0002092	biological_process	positive regulation of receptor internalization
C	0003713	molecular_function	transcription coactivator activity
C	0004402	molecular_function	histone acetyltransferase activity
C	0004857	molecular_function	enzyme inhibitor activity
C	0005096	molecular_function	GTPase activator activity
C	0005159	molecular_function	insulin-like growth factor receptor binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005765	cellular_component	lysosomal membrane
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0005905	cellular_component	clathrin-coated pit
C	0006351	biological_process	DNA-templated transcription
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0007166	biological_process	cell surface receptor signaling pathway
C	0007600	biological_process	sensory perception
C	0009968	biological_process	negative regulation of signal transduction
C	0010613	biological_process	positive regulation of cardiac muscle hypertrophy
C	0015031	biological_process	protein transport
C	0016567	biological_process	protein ubiquitination
C	0019899	molecular_function	enzyme binding
C	0030659	cellular_component	cytoplasmic vesicle membrane
C	0030666	cellular_component	endocytic vesicle membrane
C	0031143	cellular_component	pseudopodium
C	0031397	biological_process	negative regulation of protein ubiquitination
C	0031410	cellular_component	cytoplasmic vesicle
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0031701	molecular_function	angiotensin receptor binding
C	0032715	biological_process	negative regulation of interleukin-6 production
C	0032717	biological_process	negative regulation of interleukin-8 production
C	0035025	biological_process	positive regulation of Rho protein signal transduction
C	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
C	0043149	biological_process	stress fiber assembly
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0045746	biological_process	negative regulation of Notch signaling pathway
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0060090	molecular_function	molecular adaptor activity
C	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
C	1902533	biological_process	positive regulation of intracellular signal transduction
C	1990763	molecular_function	arrestin family protein binding

Functional Information from PROSITE/UniProt

site_id	PS00295
Number of Residues	19
Details	ARRESTINS Arrestins signature. FRYGrEDlDVLGLtFrKDL

Chain	Residue	Details
B	PHE61-LEU79

site_id	PS00979
Number of Residues	19
Details	G_PROTEIN_RECEP_F3_1 G-protein coupled receptors family 3 signature 1. VaNILrLFkIPQISyASTA

Chain	Residue	Details
D	VAL162-ALA180

site_id	PS00980
Number of Residues	23
Details	G_PROTEIN_RECEP_F3_2 G-protein coupled receptors family 3 signature 2. CCWhCerCegynYqv...DelSCelC

Chain	Residue	Details
D	CYS534-CYS556

site_id	PS00981
Number of Residues	11
Details	G_PROTEIN_RECEP_F3_3 G-protein coupled receptors family 3 signature 3. FNEAKpIGFTM

Chain	Residue	Details
D	PHE777-MET787

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	82
Details	Region: {"description":"Interaction with CHRM2","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	22
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	20
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q8BWG8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	48
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	98
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	38
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	48
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	10
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)