9MAE
Cryo-EM structure of heteromeric Kir4.1/5.1 potassium channel in apo state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0005242 | molecular_function | inward rectifier potassium channel activity |
| B | 0005267 | molecular_function | potassium channel activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006813 | biological_process | potassium ion transport |
| B | 0015272 | molecular_function | ATP-activated inward rectifier potassium channel activity |
| B | 0016020 | cellular_component | membrane |
| B | 0016323 | cellular_component | basolateral plasma membrane |
| B | 0035865 | biological_process | cellular response to potassium ion |
| B | 0044297 | cellular_component | cell body |
| B | 0071805 | biological_process | potassium ion transmembrane transport |
| B | 0097449 | cellular_component | astrocyte projection |
| B | 0097546 | cellular_component | ciliary base |
| B | 1905515 | biological_process | non-motile cilium assembly |
| B | 1990573 | biological_process | potassium ion import across plasma membrane |
| D | 0005242 | molecular_function | inward rectifier potassium channel activity |
| D | 0005267 | molecular_function | potassium channel activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006813 | biological_process | potassium ion transport |
| D | 0015272 | molecular_function | ATP-activated inward rectifier potassium channel activity |
| D | 0016020 | cellular_component | membrane |
| D | 0016323 | cellular_component | basolateral plasma membrane |
| D | 0035865 | biological_process | cellular response to potassium ion |
| D | 0044297 | cellular_component | cell body |
| D | 0071805 | biological_process | potassium ion transmembrane transport |
| D | 0097449 | cellular_component | astrocyte projection |
| D | 0097546 | cellular_component | ciliary base |
| D | 1905515 | biological_process | non-motile cilium assembly |
| D | 1990573 | biological_process | potassium ion import across plasma membrane |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 52 |
| Details | Transmembrane: {"description":"Helical; Name=M1","evidences":[{"source":"UniProtKB","id":"F1NHE9","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 60 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"UniProtKB","id":"F1NHE9","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 32 |
| Details | Intramembrane: {"description":"Helical; Pore-forming; Name=H5","evidences":[{"source":"UniProtKB","id":"F1NHE9","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 54 |
| Details | Transmembrane: {"description":"Helical; Name=M2","evidences":[{"source":"UniProtKB","id":"F1NHE9","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 10 |
| Details | Motif: {"description":"Selectivity filter","evidences":[{"source":"UniProtKB","id":"F1NHE9","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Site: {"description":"Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 52 |
| Details | Transmembrane: {"description":"Helical; Name=M1","evidences":[{"source":"UniProtKB","id":"P49655","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 66 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 32 |
| Details | Intramembrane: {"description":"Discontinuously helical; Pore-forming","evidences":[{"source":"UniProtKB","id":"P49655","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 50 |
| Details | Transmembrane: {"description":"Helical; Name=M2","evidences":[{"source":"UniProtKB","id":"P49655","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 10 |
| Details | Motif: {"description":"Selectivity filter","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P49655","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
