9MA5
Cryo-EM structure of heteromeric Kir4.1/5.1 potassium channel in complex with spermine
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 52 |
| Details | Transmembrane: {"description":"Helical; Name=M1","evidences":[{"source":"UniProtKB","id":"F1NHE9","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 60 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"UniProtKB","id":"F1NHE9","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 32 |
| Details | Intramembrane: {"description":"Helical; Pore-forming; Name=H5","evidences":[{"source":"UniProtKB","id":"F1NHE9","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 54 |
| Details | Transmembrane: {"description":"Helical; Name=M2","evidences":[{"source":"UniProtKB","id":"F1NHE9","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 10 |
| Details | Motif: {"description":"Selectivity filter","evidences":[{"source":"UniProtKB","id":"F1NHE9","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Site: {"description":"Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 52 |
| Details | Transmembrane: {"description":"Helical; Name=M1","evidences":[{"source":"UniProtKB","id":"P49655","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 66 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 32 |
| Details | Intramembrane: {"description":"Discontinuously helical; Pore-forming","evidences":[{"source":"UniProtKB","id":"P49655","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 50 |
| Details | Transmembrane: {"description":"Helical; Name=M2","evidences":[{"source":"UniProtKB","id":"P49655","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 10 |
| Details | Motif: {"description":"Selectivity filter","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P49655","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
