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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9M8S

Cryo-EM structure of the human TRPA1 ion channel in ligand-free state.

Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DISDTRLLNegDL
ChainResidueDetails
BASP468-LEU480
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"31866091","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PQO","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues92
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"31866091","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PQO","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues44
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues116
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"31866091","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PQO","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues80
DetailsIntramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"31866091","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PQO","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues104
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"31866091","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PQO","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues116
DetailsRepeat: {"description":"ANK 13","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25855297","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues116
DetailsRepeat: {"description":"ANK 14","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25855297","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues116
DetailsRepeat: {"description":"ANK 15","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25855297","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues120
DetailsRepeat: {"description":"ANK 16","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25855297","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues116
DetailsCoiled coil: {"evidences":[{"source":"PubMed","id":"25855297","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues4
DetailsBinding site: {"description":"covalent; Cys highly reactive","evidences":[{"source":"UniProtKB","id":"Q8BLA8","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"17164327","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27241698","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues8
DetailsBinding site: {"description":"covalent","evidences":[{"source":"PubMed","id":"17164327","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues4
DetailsBinding site: {"description":"covalent","evidences":[{"source":"PubMed","id":"17164327","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27241698","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"32641835","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6V9V","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues24
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"25855297","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues4
DetailsSite: {"description":"Required for C-621 reactivity","evidences":[{"source":"PubMed","id":"27241698","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues4
DetailsSite: {"description":"Essential for electrophile activation. Sensor for electrophilic agents","evidences":[{"source":"PubMed","id":"31866091","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32641835","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues4
DetailsSite: {"description":"Key residue for activation by the scorpion wasabi receptor toxin","evidences":[{"source":"PubMed","id":"31447178","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues8
DetailsSite: {"description":"Important residue for activation by the scorpion wasabi receptor toxin","evidences":[{"source":"PubMed","id":"31447178","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues4
DetailsSite: {"description":"Important for electrophile activation","evidences":[{"source":"PubMed","id":"31866091","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32641835","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues4
DetailsSite: {"description":"Crucial for calcium permeation","evidences":[{"source":"UniProtKB","id":"Q6RI86","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues8
DetailsModified residue: {"description":"Cysteine sulfenic acid (-SOH); transient; in hyperoxia","evidences":[{"source":"PubMed","id":"21873995","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues8
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

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PDB entries from 2025-10-29

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