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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9M5V

Structure of human TRPC5 bound with (-)-englerin A,class1

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0003779molecular_functionactin binding
A0005262molecular_functioncalcium channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006816biological_processcalcium ion transport
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0007399biological_processnervous system development
A0008284biological_processpositive regulation of cell population proliferation
A0015279molecular_functionstore-operated calcium channel activity
A0030182biological_processneuron differentiation
A0030276molecular_functionclathrin binding
A0030425cellular_componentdendrite
A0030426cellular_componentgrowth cone
A0034220biological_processmonoatomic ion transmembrane transport
A0034703cellular_componentcation channel complex
A0034704cellular_componentcalcium channel complex
A0042805molecular_functionactinin binding
A0043025cellular_componentneuronal cell body
A0045666biological_processpositive regulation of neuron differentiation
A0045773biological_processpositive regulation of axon extension
A0046872molecular_functionmetal ion binding
A0050774biological_processnegative regulation of dendrite morphogenesis
A0051117molecular_functionATPase binding
A0051402biological_processneuron apoptotic process
A0051480biological_processregulation of cytosolic calcium ion concentration
A0070588biological_processcalcium ion transmembrane transport
A0070679molecular_functioninositol 1,4,5 trisphosphate binding
A0070782biological_processphosphatidylserine exposure on apoptotic cell surface
A0098793cellular_componentpresynapse
A1902630biological_processregulation of membrane hyperpolarization
B0003779molecular_functionactin binding
B0005262molecular_functioncalcium channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006816biological_processcalcium ion transport
B0007204biological_processpositive regulation of cytosolic calcium ion concentration
B0007399biological_processnervous system development
B0008284biological_processpositive regulation of cell population proliferation
B0015279molecular_functionstore-operated calcium channel activity
B0030182biological_processneuron differentiation
B0030276molecular_functionclathrin binding
B0030425cellular_componentdendrite
B0030426cellular_componentgrowth cone
B0034220biological_processmonoatomic ion transmembrane transport
B0034703cellular_componentcation channel complex
B0034704cellular_componentcalcium channel complex
B0042805molecular_functionactinin binding
B0043025cellular_componentneuronal cell body
B0045666biological_processpositive regulation of neuron differentiation
B0045773biological_processpositive regulation of axon extension
B0046872molecular_functionmetal ion binding
B0050774biological_processnegative regulation of dendrite morphogenesis
B0051117molecular_functionATPase binding
B0051402biological_processneuron apoptotic process
B0051480biological_processregulation of cytosolic calcium ion concentration
B0070588biological_processcalcium ion transmembrane transport
B0070679molecular_functioninositol 1,4,5 trisphosphate binding
B0070782biological_processphosphatidylserine exposure on apoptotic cell surface
B0098793cellular_componentpresynapse
B1902630biological_processregulation of membrane hyperpolarization
C0003779molecular_functionactin binding
C0005262molecular_functioncalcium channel activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006816biological_processcalcium ion transport
C0007204biological_processpositive regulation of cytosolic calcium ion concentration
C0007399biological_processnervous system development
C0008284biological_processpositive regulation of cell population proliferation
C0015279molecular_functionstore-operated calcium channel activity
C0030182biological_processneuron differentiation
C0030276molecular_functionclathrin binding
C0030425cellular_componentdendrite
C0030426cellular_componentgrowth cone
C0034220biological_processmonoatomic ion transmembrane transport
C0034703cellular_componentcation channel complex
C0034704cellular_componentcalcium channel complex
C0042805molecular_functionactinin binding
C0043025cellular_componentneuronal cell body
C0045666biological_processpositive regulation of neuron differentiation
C0045773biological_processpositive regulation of axon extension
C0046872molecular_functionmetal ion binding
C0050774biological_processnegative regulation of dendrite morphogenesis
C0051117molecular_functionATPase binding
C0051402biological_processneuron apoptotic process
C0051480biological_processregulation of cytosolic calcium ion concentration
C0070588biological_processcalcium ion transmembrane transport
C0070679molecular_functioninositol 1,4,5 trisphosphate binding
C0070782biological_processphosphatidylserine exposure on apoptotic cell surface
C0098793cellular_componentpresynapse
C1902630biological_processregulation of membrane hyperpolarization
D0003779molecular_functionactin binding
D0005262molecular_functioncalcium channel activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006816biological_processcalcium ion transport
D0007204biological_processpositive regulation of cytosolic calcium ion concentration
D0007399biological_processnervous system development
D0008284biological_processpositive regulation of cell population proliferation
D0015279molecular_functionstore-operated calcium channel activity
D0030182biological_processneuron differentiation
D0030276molecular_functionclathrin binding
D0030425cellular_componentdendrite
D0030426cellular_componentgrowth cone
D0034220biological_processmonoatomic ion transmembrane transport
D0034703cellular_componentcation channel complex
D0034704cellular_componentcalcium channel complex
D0042805molecular_functionactinin binding
D0043025cellular_componentneuronal cell body
D0045666biological_processpositive regulation of neuron differentiation
D0045773biological_processpositive regulation of axon extension
D0046872molecular_functionmetal ion binding
D0050774biological_processnegative regulation of dendrite morphogenesis
D0051117molecular_functionATPase binding
D0051402biological_processneuron apoptotic process
D0051480biological_processregulation of cytosolic calcium ion concentration
D0070588biological_processcalcium ion transmembrane transport
D0070679molecular_functioninositol 1,4,5 trisphosphate binding
D0070782biological_processphosphatidylserine exposure on apoptotic cell surface
D0098793cellular_componentpresynapse
D1902630biological_processregulation of membrane hyperpolarization
Functional Information from PROSITE/UniProt
site_idPS00962
Number of Residues12
DetailsRIBOSOMAL_S2_1 Ribosomal protein S2 signature 1. LiSLFTANSHLG
ChainResidueDetails
ALEU493-GLY504
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues136
DetailsIntramembrane: {"description":"Discontinuously helical; Name=Pre-S1","evidences":[{"source":"PubMed","id":"37137991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7X6C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7X6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues116
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"37137991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7X6C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7X6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=S1","evidences":[{"source":"PubMed","id":"37137991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7X6C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7X6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues56
DetailsTransmembrane: {"description":"Helical; Name=S2","evidences":[{"source":"PubMed","id":"37137991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7X6C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7X6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=S3","evidences":[{"source":"PubMed","id":"37137991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7X6C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7X6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues352
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"37137991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7X6C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7X6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=S4","evidences":[{"source":"PubMed","id":"37137991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7X6C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7X6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues88
DetailsTransmembrane: {"description":"Helical; Name=S5","evidences":[{"source":"PubMed","id":"37137991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7X6C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7X6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=S6","evidences":[{"source":"PubMed","id":"37137991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7X6C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7X6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues120
DetailsRepeat: {"description":"ANK 1","evidences":[{"source":"PubMed","id":"37137991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7X6C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7X6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues112
DetailsRepeat: {"description":"ANK 2","evidences":[{"source":"PubMed","id":"37137991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7X6C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7X6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues116
DetailsRepeat: {"description":"ANK 4","evidences":[{"source":"PubMed","id":"37137991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7X6C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7X6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues28
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"37137991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7X6C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7X6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"37137991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7X6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

247947

PDB entries from 2026-01-21

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