9M2Q

Imidazole glycerol phosphate dehydratase from Mycobacterium tuberculosis, in complex with aminotriazole

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000105	biological_process	L-histidine biosynthetic process
A	0003824	molecular_function	catalytic activity
A	0004424	molecular_function	imidazoleglycerol-phosphate dehydratase activity
A	0005737	cellular_component	cytoplasm
A	0008652	biological_process	amino acid biosynthetic process
A	0016829	molecular_function	lyase activity
A	0046872	molecular_function	metal ion binding
B	0000105	biological_process	L-histidine biosynthetic process
B	0003824	molecular_function	catalytic activity
B	0004424	molecular_function	imidazoleglycerol-phosphate dehydratase activity
B	0005737	cellular_component	cytoplasm
B	0008652	biological_process	amino acid biosynthetic process
B	0016829	molecular_function	lyase activity
B	0046872	molecular_function	metal ion binding
C	0000105	biological_process	L-histidine biosynthetic process
C	0003824	molecular_function	catalytic activity
C	0004424	molecular_function	imidazoleglycerol-phosphate dehydratase activity
C	0005737	cellular_component	cytoplasm
C	0008652	biological_process	amino acid biosynthetic process
C	0016829	molecular_function	lyase activity
C	0046872	molecular_function	metal ion binding
D	0000105	biological_process	L-histidine biosynthetic process
D	0003824	molecular_function	catalytic activity
D	0004424	molecular_function	imidazoleglycerol-phosphate dehydratase activity
D	0005737	cellular_component	cytoplasm
D	0008652	biological_process	amino acid biosynthetic process
D	0016829	molecular_function	lyase activity
D	0046872	molecular_function	metal ion binding
E	0000105	biological_process	L-histidine biosynthetic process
E	0003824	molecular_function	catalytic activity
E	0004424	molecular_function	imidazoleglycerol-phosphate dehydratase activity
E	0005737	cellular_component	cytoplasm
E	0008652	biological_process	amino acid biosynthetic process
E	0016829	molecular_function	lyase activity
E	0046872	molecular_function	metal ion binding
F	0000105	biological_process	L-histidine biosynthetic process
F	0003824	molecular_function	catalytic activity
F	0004424	molecular_function	imidazoleglycerol-phosphate dehydratase activity
F	0005737	cellular_component	cytoplasm
F	0008652	biological_process	amino acid biosynthetic process
F	0016829	molecular_function	lyase activity
F	0046872	molecular_function	metal ion binding
G	0000105	biological_process	L-histidine biosynthetic process
G	0003824	molecular_function	catalytic activity
G	0004424	molecular_function	imidazoleglycerol-phosphate dehydratase activity
G	0005737	cellular_component	cytoplasm
G	0008652	biological_process	amino acid biosynthetic process
G	0016829	molecular_function	lyase activity
G	0046872	molecular_function	metal ion binding
H	0000105	biological_process	L-histidine biosynthetic process
H	0003824	molecular_function	catalytic activity
H	0004424	molecular_function	imidazoleglycerol-phosphate dehydratase activity
H	0005737	cellular_component	cytoplasm
H	0008652	biological_process	amino acid biosynthetic process
H	0016829	molecular_function	lyase activity
H	0046872	molecular_function	metal ion binding
I	0000105	biological_process	L-histidine biosynthetic process
I	0003824	molecular_function	catalytic activity
I	0004424	molecular_function	imidazoleglycerol-phosphate dehydratase activity
I	0005737	cellular_component	cytoplasm
I	0008652	biological_process	amino acid biosynthetic process
I	0016829	molecular_function	lyase activity
I	0046872	molecular_function	metal ion binding
J	0000105	biological_process	L-histidine biosynthetic process
J	0003824	molecular_function	catalytic activity
J	0004424	molecular_function	imidazoleglycerol-phosphate dehydratase activity
J	0005737	cellular_component	cytoplasm
J	0008652	biological_process	amino acid biosynthetic process
J	0016829	molecular_function	lyase activity
J	0046872	molecular_function	metal ion binding
K	0000105	biological_process	L-histidine biosynthetic process
K	0003824	molecular_function	catalytic activity
K	0004424	molecular_function	imidazoleglycerol-phosphate dehydratase activity
K	0005737	cellular_component	cytoplasm
K	0008652	biological_process	amino acid biosynthetic process
K	0016829	molecular_function	lyase activity
K	0046872	molecular_function	metal ion binding
L	0000105	biological_process	L-histidine biosynthetic process
L	0003824	molecular_function	catalytic activity
L	0004424	molecular_function	imidazoleglycerol-phosphate dehydratase activity
L	0005737	cellular_component	cytoplasm
L	0008652	biological_process	amino acid biosynthetic process
L	0016829	molecular_function	lyase activity
L	0046872	molecular_function	metal ion binding
M	0000105	biological_process	L-histidine biosynthetic process
M	0003824	molecular_function	catalytic activity
M	0004424	molecular_function	imidazoleglycerol-phosphate dehydratase activity
M	0005737	cellular_component	cytoplasm
M	0008652	biological_process	amino acid biosynthetic process
M	0016829	molecular_function	lyase activity
M	0046872	molecular_function	metal ion binding
N	0000105	biological_process	L-histidine biosynthetic process
N	0003824	molecular_function	catalytic activity
N	0004424	molecular_function	imidazoleglycerol-phosphate dehydratase activity
N	0005737	cellular_component	cytoplasm
N	0008652	biological_process	amino acid biosynthetic process
N	0016829	molecular_function	lyase activity
N	0046872	molecular_function	metal ion binding
O	0000105	biological_process	L-histidine biosynthetic process
O	0003824	molecular_function	catalytic activity
O	0004424	molecular_function	imidazoleglycerol-phosphate dehydratase activity
O	0005737	cellular_component	cytoplasm
O	0008652	biological_process	amino acid biosynthetic process
O	0016829	molecular_function	lyase activity
O	0046872	molecular_function	metal ion binding
P	0000105	biological_process	L-histidine biosynthetic process
P	0003824	molecular_function	catalytic activity
P	0004424	molecular_function	imidazoleglycerol-phosphate dehydratase activity
P	0005737	cellular_component	cytoplasm
P	0008652	biological_process	amino acid biosynthetic process
P	0016829	molecular_function	lyase activity
P	0046872	molecular_function	metal ion binding
Q	0000105	biological_process	L-histidine biosynthetic process
Q	0003824	molecular_function	catalytic activity
Q	0004424	molecular_function	imidazoleglycerol-phosphate dehydratase activity
Q	0005737	cellular_component	cytoplasm
Q	0008652	biological_process	amino acid biosynthetic process
Q	0016829	molecular_function	lyase activity
Q	0046872	molecular_function	metal ion binding
R	0000105	biological_process	L-histidine biosynthetic process
R	0003824	molecular_function	catalytic activity
R	0004424	molecular_function	imidazoleglycerol-phosphate dehydratase activity
R	0005737	cellular_component	cytoplasm
R	0008652	biological_process	amino acid biosynthetic process
R	0016829	molecular_function	lyase activity
R	0046872	molecular_function	metal ion binding
S	0000105	biological_process	L-histidine biosynthetic process
S	0003824	molecular_function	catalytic activity
S	0004424	molecular_function	imidazoleglycerol-phosphate dehydratase activity
S	0005737	cellular_component	cytoplasm
S	0008652	biological_process	amino acid biosynthetic process
S	0016829	molecular_function	lyase activity
S	0046872	molecular_function	metal ion binding
T	0000105	biological_process	L-histidine biosynthetic process
T	0003824	molecular_function	catalytic activity
T	0004424	molecular_function	imidazoleglycerol-phosphate dehydratase activity
T	0005737	cellular_component	cytoplasm
T	0008652	biological_process	amino acid biosynthetic process
T	0016829	molecular_function	lyase activity
T	0046872	molecular_function	metal ion binding
U	0000105	biological_process	L-histidine biosynthetic process
U	0003824	molecular_function	catalytic activity
U	0004424	molecular_function	imidazoleglycerol-phosphate dehydratase activity
U	0005737	cellular_component	cytoplasm
U	0008652	biological_process	amino acid biosynthetic process
U	0016829	molecular_function	lyase activity
U	0046872	molecular_function	metal ion binding
V	0000105	biological_process	L-histidine biosynthetic process
V	0003824	molecular_function	catalytic activity
V	0004424	molecular_function	imidazoleglycerol-phosphate dehydratase activity
V	0005737	cellular_component	cytoplasm
V	0008652	biological_process	amino acid biosynthetic process
V	0016829	molecular_function	lyase activity
V	0046872	molecular_function	metal ion binding
W	0000105	biological_process	L-histidine biosynthetic process
W	0003824	molecular_function	catalytic activity
W	0004424	molecular_function	imidazoleglycerol-phosphate dehydratase activity
W	0005737	cellular_component	cytoplasm
W	0008652	biological_process	amino acid biosynthetic process
W	0016829	molecular_function	lyase activity
W	0046872	molecular_function	metal ion binding
X	0000105	biological_process	L-histidine biosynthetic process
X	0003824	molecular_function	catalytic activity
X	0004424	molecular_function	imidazoleglycerol-phosphate dehydratase activity
X	0005737	cellular_component	cytoplasm
X	0008652	biological_process	amino acid biosynthetic process
X	0016829	molecular_function	lyase activity
X	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00954
Number of Residues	14
Details	IGP_DEHYDRATASE_1 Imidazoleglycerol-phosphate dehydratase signature 1. IEaHHtiEdtAIAL

Chain	Residue	Details
A	ILE70-LEU83

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site_id	PS00955
Number of Residues	13
Details	IGP_DEHYDRATASE_2 Imidazoleglycerol-phosphate dehydratase signature 2. GrDpHHitEAqYK

Chain	Residue	Details
A	GLY172-LYS184

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	72
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"O23346","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	384
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24311587","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ZQN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	192
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24311587","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4GQU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	96
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24311587","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5XDS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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