9M0Y

Local refinement of stacked like DDB1-DDA1-DET1-Ube2e2-COP1 complex (layer 2)

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005515	molecular_function	protein binding
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0010212	biological_process	response to ionizing radiation
A	0016567	biological_process	protein ubiquitination
A	0016607	cellular_component	nuclear speck
A	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
A	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0045717	biological_process	negative regulation of fatty acid biosynthetic process
A	0061630	molecular_function	ubiquitin protein ligase activity
B	0000139	cellular_component	Golgi membrane
B	0004842	molecular_function	ubiquitin-protein transferase activity
B	0005515	molecular_function	protein binding
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0010212	biological_process	response to ionizing radiation
B	0016567	biological_process	protein ubiquitination
B	0016607	cellular_component	nuclear speck
B	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
B	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0045717	biological_process	negative regulation of fatty acid biosynthetic process
B	0061630	molecular_function	ubiquitin protein ligase activity
C	0000139	cellular_component	Golgi membrane
C	0004842	molecular_function	ubiquitin-protein transferase activity
C	0005515	molecular_function	protein binding
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0010212	biological_process	response to ionizing radiation
C	0016567	biological_process	protein ubiquitination
C	0016607	cellular_component	nuclear speck
C	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
C	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0045717	biological_process	negative regulation of fatty acid biosynthetic process
C	0061630	molecular_function	ubiquitin protein ligase activity
D	0000139	cellular_component	Golgi membrane
D	0004842	molecular_function	ubiquitin-protein transferase activity
D	0005515	molecular_function	protein binding
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0010212	biological_process	response to ionizing radiation
D	0016567	biological_process	protein ubiquitination
D	0016607	cellular_component	nuclear speck
D	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
D	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0045717	biological_process	negative regulation of fatty acid biosynthetic process
D	0061630	molecular_function	ubiquitin protein ligase activity
E	0000139	cellular_component	Golgi membrane
E	0004842	molecular_function	ubiquitin-protein transferase activity
E	0005515	molecular_function	protein binding
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0010212	biological_process	response to ionizing radiation
E	0016567	biological_process	protein ubiquitination
E	0016607	cellular_component	nuclear speck
E	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
E	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0045717	biological_process	negative regulation of fatty acid biosynthetic process
E	0061630	molecular_function	ubiquitin protein ligase activity
F	0000139	cellular_component	Golgi membrane
F	0004842	molecular_function	ubiquitin-protein transferase activity
F	0005515	molecular_function	protein binding
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0010212	biological_process	response to ionizing radiation
F	0016567	biological_process	protein ubiquitination
F	0016607	cellular_component	nuclear speck
F	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
F	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0045717	biological_process	negative regulation of fatty acid biosynthetic process
F	0061630	molecular_function	ubiquitin protein ligase activity
G	0000139	cellular_component	Golgi membrane
G	0004842	molecular_function	ubiquitin-protein transferase activity
G	0005515	molecular_function	protein binding
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0010212	biological_process	response to ionizing radiation
G	0016567	biological_process	protein ubiquitination
G	0016607	cellular_component	nuclear speck
G	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
G	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0045717	biological_process	negative regulation of fatty acid biosynthetic process
G	0061630	molecular_function	ubiquitin protein ligase activity
j	0000209	biological_process	protein polyubiquitination
j	0005515	molecular_function	protein binding
j	0005654	cellular_component	nucleoplasm
j	0016567	biological_process	protein ubiquitination
j	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
j	0032814	biological_process	regulation of natural killer cell activation
j	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
J	0000139	cellular_component	Golgi membrane
J	0004842	molecular_function	ubiquitin-protein transferase activity
J	0005515	molecular_function	protein binding
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006511	biological_process	ubiquitin-dependent protein catabolic process
J	0010212	biological_process	response to ionizing radiation
J	0016567	biological_process	protein ubiquitination
J	0016607	cellular_component	nuclear speck
J	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
J	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0045717	biological_process	negative regulation of fatty acid biosynthetic process
J	0061630	molecular_function	ubiquitin protein ligase activity
n	0000209	biological_process	protein polyubiquitination
n	0005515	molecular_function	protein binding
n	0005654	cellular_component	nucleoplasm
n	0016567	biological_process	protein ubiquitination
n	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
n	0032814	biological_process	regulation of natural killer cell activation
n	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
Q	0004842	molecular_function	ubiquitin-protein transferase activity
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0006513	biological_process	protein monoubiquitination
Q	0006974	biological_process	DNA damage response
Q	0016567	biological_process	protein ubiquitination
Q	0032020	biological_process	ISG15-protein conjugation
Q	0042296	molecular_function	ISG15 transferase activity
Q	0061631	molecular_function	ubiquitin conjugating enzyme activity
Q	0070534	biological_process	protein K63-linked ubiquitination
Q	0070936	biological_process	protein K48-linked ubiquitination
Q	0070979	biological_process	protein K11-linked ubiquitination
Q	1900087	biological_process	positive regulation of G1/S transition of mitotic cell cycle
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0016567	biological_process	protein ubiquitination
R	0031461	cellular_component	cullin-RING ubiquitin ligase complex
R	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
R	0031625	molecular_function	ubiquitin protein ligase binding
R	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
R	0044877	molecular_function	protein-containing complex binding
R	0065003	biological_process	protein-containing complex assembly
R	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
R	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
S	0000781	cellular_component	chromosome, telomeric region
S	0003677	molecular_function	DNA binding
S	0003684	molecular_function	damaged DNA binding
S	0005515	molecular_function	protein binding
S	0005576	cellular_component	extracellular region
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005730	cellular_component	nucleolus
S	0005737	cellular_component	cytoplasm
S	0006281	biological_process	DNA repair
S	0006289	biological_process	nucleotide-excision repair
S	0006511	biological_process	ubiquitin-dependent protein catabolic process
S	0006974	biological_process	DNA damage response
S	0007056	biological_process	spindle assembly involved in female meiosis
S	0007283	biological_process	spermatogenesis
S	0008283	biological_process	cell population proliferation
S	0010498	biological_process	proteasomal protein catabolic process
S	0010506	biological_process	regulation of autophagy
S	0016567	biological_process	protein ubiquitination
S	0019076	biological_process	viral release from host cell
S	0030174	biological_process	regulation of DNA-templated DNA replication initiation
S	0030674	molecular_function	protein-macromolecule adaptor activity
S	0031297	biological_process	replication fork processing
S	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
S	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
S	0032814	biological_process	regulation of natural killer cell activation
S	0032991	cellular_component	protein-containing complex
S	0034644	biological_process	cellular response to UV
S	0035861	cellular_component	site of double-strand break
S	0040029	biological_process	epigenetic regulation of gene expression
S	0042127	biological_process	regulation of cell population proliferation
S	0042752	biological_process	regulation of circadian rhythm
S	0042981	biological_process	regulation of apoptotic process
S	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
S	0044725	biological_process	epigenetic programming in the zygotic pronuclei
S	0044877	molecular_function	protein-containing complex binding
S	0045070	biological_process	positive regulation of viral genome replication
S	0045722	biological_process	positive regulation of gluconeogenesis
S	0045732	biological_process	positive regulation of protein catabolic process
S	0045995	biological_process	regulation of embryonic development
S	0046726	biological_process	positive regulation by virus of viral protein levels in host cell
S	0051702	biological_process	biological process involved in interaction with symbiont
S	0060964	biological_process	regulation of miRNA-mediated gene silencing
S	0070062	cellular_component	extracellular exosome
S	0070914	biological_process	UV-damage excision repair
S	0071987	molecular_function	WD40-repeat domain binding
S	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
S	0080135	biological_process	regulation of cellular response to stress
S	0097602	molecular_function	cullin family protein binding
S	0160072	molecular_function	ubiquitin ligase complex scaffold activity
S	1901987	biological_process	regulation of cell cycle phase transition
S	1901990	biological_process	regulation of mitotic cell cycle phase transition
S	1902412	biological_process	regulation of mitotic cytokinesis
S	1904178	biological_process	negative regulation of adipose tissue development
S	2000036	biological_process	regulation of stem cell population maintenance
T	0004842	molecular_function	ubiquitin-protein transferase activity
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0006513	biological_process	protein monoubiquitination
T	0006974	biological_process	DNA damage response
T	0016567	biological_process	protein ubiquitination
T	0032020	biological_process	ISG15-protein conjugation
T	0042296	molecular_function	ISG15 transferase activity
T	0061631	molecular_function	ubiquitin conjugating enzyme activity
T	0070534	biological_process	protein K63-linked ubiquitination
T	0070936	biological_process	protein K48-linked ubiquitination
T	0070979	biological_process	protein K11-linked ubiquitination
T	1900087	biological_process	positive regulation of G1/S transition of mitotic cell cycle
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0016567	biological_process	protein ubiquitination
U	0031461	cellular_component	cullin-RING ubiquitin ligase complex
U	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
U	0031625	molecular_function	ubiquitin protein ligase binding
U	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
U	0044877	molecular_function	protein-containing complex binding
U	0065003	biological_process	protein-containing complex assembly
U	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
U	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
V	0000781	cellular_component	chromosome, telomeric region
V	0003677	molecular_function	DNA binding
V	0003684	molecular_function	damaged DNA binding
V	0005515	molecular_function	protein binding
V	0005576	cellular_component	extracellular region
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005730	cellular_component	nucleolus
V	0005737	cellular_component	cytoplasm
V	0006281	biological_process	DNA repair
V	0006289	biological_process	nucleotide-excision repair
V	0006511	biological_process	ubiquitin-dependent protein catabolic process
V	0006974	biological_process	DNA damage response
V	0007056	biological_process	spindle assembly involved in female meiosis
V	0007283	biological_process	spermatogenesis
V	0008283	biological_process	cell population proliferation
V	0010498	biological_process	proteasomal protein catabolic process
V	0010506	biological_process	regulation of autophagy
V	0016567	biological_process	protein ubiquitination
V	0019076	biological_process	viral release from host cell
V	0030174	biological_process	regulation of DNA-templated DNA replication initiation
V	0030674	molecular_function	protein-macromolecule adaptor activity
V	0031297	biological_process	replication fork processing
V	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
V	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
V	0032814	biological_process	regulation of natural killer cell activation
V	0032991	cellular_component	protein-containing complex
V	0034644	biological_process	cellular response to UV
V	0035861	cellular_component	site of double-strand break
V	0040029	biological_process	epigenetic regulation of gene expression
V	0042127	biological_process	regulation of cell population proliferation
V	0042752	biological_process	regulation of circadian rhythm
V	0042981	biological_process	regulation of apoptotic process
V	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
V	0044725	biological_process	epigenetic programming in the zygotic pronuclei
V	0044877	molecular_function	protein-containing complex binding
V	0045070	biological_process	positive regulation of viral genome replication
V	0045722	biological_process	positive regulation of gluconeogenesis
V	0045732	biological_process	positive regulation of protein catabolic process
V	0045995	biological_process	regulation of embryonic development
V	0046726	biological_process	positive regulation by virus of viral protein levels in host cell
V	0051702	biological_process	biological process involved in interaction with symbiont
V	0060964	biological_process	regulation of miRNA-mediated gene silencing
V	0070062	cellular_component	extracellular exosome
V	0070914	biological_process	UV-damage excision repair
V	0071987	molecular_function	WD40-repeat domain binding
V	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
V	0080135	biological_process	regulation of cellular response to stress
V	0097602	molecular_function	cullin family protein binding
V	0160072	molecular_function	ubiquitin ligase complex scaffold activity
V	1901987	biological_process	regulation of cell cycle phase transition
V	1901990	biological_process	regulation of mitotic cell cycle phase transition
V	1902412	biological_process	regulation of mitotic cytokinesis
V	1904178	biological_process	negative regulation of adipose tissue development
V	2000036	biological_process	regulation of stem cell population maintenance

Functional Information from PROSITE/UniProt

site_id	PS00183
Number of Residues	16
Details	UBC_1 Ubiquitin-conjugating (UBC) active site signature. YHCNInsq.GvICLdiL

Chain	Residue	Details
Q	TYR120-LEU135

---

site_id	PS00518
Number of Residues	10
Details	ZF_RING_1 Zinc finger RING-type signature. CgHsFCykCI

Chain	Residue	Details
A	CYS151-ILE160

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. IVSAstDsQLKLWNV

Chain	Residue	Details
A	ILE613-VAL627

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	234
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	320
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	320
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	320
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	304
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	312
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	16
Details	Region: {"description":"Interaction with TRIB1","evidences":[{"source":"PubMed","id":"27041596","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	80
Details	Motif: {"description":"Nuclear export signal","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	16
Details	Site: {"description":"Interaction with TRIB1","evidences":[{"source":"PubMed","id":"27041596","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	152
Details	Zinc finger: {"description":"RING-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	272
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	292
Details	Domain: {"description":"UBC core","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10133","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	686
Details	Region: {"description":"WD repeat beta-propeller A"}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	738
Details	Region: {"description":"Interaction with CDT1 and CUL4A","evidences":[{"source":"PubMed","id":"15448697","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q9ESW0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---