9M0H

Crystal structure of human endonuclease G mutant C113A/H141A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004520	molecular_function	DNA endonuclease activity
A	0004521	molecular_function	RNA endonuclease activity
A	0004536	molecular_function	DNA nuclease activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0006308	biological_process	DNA catabolic process
A	0006309	biological_process	apoptotic DNA fragmentation
A	0006310	biological_process	DNA recombination
A	0006974	biological_process	DNA damage response
A	0009612	biological_process	response to mechanical stimulus
A	0010508	biological_process	positive regulation of autophagy
A	0032007	biological_process	negative regulation of TOR signaling
A	0032043	biological_process	mitochondrial DNA catabolic process
A	0032355	biological_process	response to estradiol
A	0034599	biological_process	cellular response to oxidative stress
A	0042803	molecular_function	protein homodimerization activity
A	0043204	cellular_component	perikaryon
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0071277	biological_process	cellular response to calcium ion
A	0071333	biological_process	cellular response to glucose stimulus
A	0071456	biological_process	cellular response to hypoxia
A	0090297	biological_process	positive regulation of mitochondrial DNA replication
A	1901300	biological_process	positive regulation of hydrogen peroxide-mediated programmed cell death
A	1902512	biological_process	positive regulation of apoptotic DNA fragmentation
B	0000287	molecular_function	magnesium ion binding
B	0004520	molecular_function	DNA endonuclease activity
B	0004521	molecular_function	RNA endonuclease activity
B	0004536	molecular_function	DNA nuclease activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0006308	biological_process	DNA catabolic process
B	0006309	biological_process	apoptotic DNA fragmentation
B	0006310	biological_process	DNA recombination
B	0006974	biological_process	DNA damage response
B	0009612	biological_process	response to mechanical stimulus
B	0010508	biological_process	positive regulation of autophagy
B	0032007	biological_process	negative regulation of TOR signaling
B	0032043	biological_process	mitochondrial DNA catabolic process
B	0032355	biological_process	response to estradiol
B	0034599	biological_process	cellular response to oxidative stress
B	0042803	molecular_function	protein homodimerization activity
B	0043204	cellular_component	perikaryon
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0071277	biological_process	cellular response to calcium ion
B	0071333	biological_process	cellular response to glucose stimulus
B	0071456	biological_process	cellular response to hypoxia
B	0090297	biological_process	positive regulation of mitochondrial DNA replication
B	1901300	biological_process	positive regulation of hydrogen peroxide-mediated programmed cell death
B	1902512	biological_process	positive regulation of apoptotic DNA fragmentation

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10047","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"O08600","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Site: {"description":"Essential for catalytic activity","evidences":[{"source":"UniProtKB","id":"O08600","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by GSK3-beta","evidences":[{"source":"PubMed","id":"33473107","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by GSK3-beta","evidences":[{"source":"PubMed","id":"33473107","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---