9LYD
Cryo-EM structure of GPR3-1IU9 complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| Q | 0003376 | biological_process | sphingosine-1-phosphate receptor signaling pathway |
| Q | 0004930 | molecular_function | G protein-coupled receptor activity |
| Q | 0005515 | molecular_function | protein binding |
| Q | 0005737 | cellular_component | cytoplasm |
| Q | 0005886 | cellular_component | plasma membrane |
| Q | 0007165 | biological_process | signal transduction |
| Q | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| Q | 0007189 | biological_process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| Q | 0016020 | cellular_component | membrane |
| Q | 0038036 | molecular_function | sphingosine-1-phosphate receptor activity |
| Q | 0040020 | biological_process | regulation of meiotic nuclear division |
| Q | 0120162 | biological_process | positive regulation of cold-induced thermogenesis |
| R | 0003376 | biological_process | sphingosine-1-phosphate receptor signaling pathway |
| R | 0004930 | molecular_function | G protein-coupled receptor activity |
| R | 0005515 | molecular_function | protein binding |
| R | 0005737 | cellular_component | cytoplasm |
| R | 0005886 | cellular_component | plasma membrane |
| R | 0007165 | biological_process | signal transduction |
| R | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| R | 0007189 | biological_process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| R | 0016020 | cellular_component | membrane |
| R | 0038036 | molecular_function | sphingosine-1-phosphate receptor activity |
| R | 0040020 | biological_process | regulation of meiotic nuclear division |
| R | 0120162 | biological_process | positive regulation of cold-induced thermogenesis |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIgSLLAITVDRYLsL |
| Chain | Residue | Details |
| Q | ALA122-LEU138 |
| site_id | PS00924 |
| Number of Residues | 11 |
| Details | ASP_GLU_RACEMASE_2 Aspartate and glutamate racemases signature 2. IIaGCTEVSvV |
| Chain | Residue | Details |
| Q | ILE1088-VAL1098 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"17847084","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17847084","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2DX7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 38 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 62 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 46 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 78 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 42 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 38 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 36 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 52 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 42 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
