9LX5
Cryo-EM structure of the P2X1 receptor bound to ATP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001614 | molecular_function | purinergic nucleotide receptor activity |
| A | 0004931 | molecular_function | extracellularly ATP-gated monoatomic cation channel activity |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0033198 | biological_process | response to ATP |
| A | 0098655 | biological_process | monoatomic cation transmembrane transport |
| B | 0001614 | molecular_function | purinergic nucleotide receptor activity |
| B | 0004931 | molecular_function | extracellularly ATP-gated monoatomic cation channel activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0033198 | biological_process | response to ATP |
| B | 0098655 | biological_process | monoatomic cation transmembrane transport |
| C | 0001614 | molecular_function | purinergic nucleotide receptor activity |
| C | 0004931 | molecular_function | extracellularly ATP-gated monoatomic cation channel activity |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0033198 | biological_process | response to ATP |
| C | 0098655 | biological_process | monoatomic cation transmembrane transport |
Functional Information from PROSITE/UniProt
| site_id | PS01212 |
| Number of Residues | 27 |
| Details | P2X_RECEPTOR ATP P2X receptors signature. GGvVGItIdWhCDLDwhvrhCrPiYeF |
| Chain | Residue | Details |
| A | GLY250-PHE276 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 42 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 861 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"UniProtKB","id":"P56373","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 21 |
| Details | Region: {"description":"Pore-forming motif","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 21 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"F8W463","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P56373","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 12 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
