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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9LUL

Local refinement of stacked like DDB1-DDA1-DET1-Ube2e2-COP1 complex (layer 1)

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
b0005515molecular_functionprotein binding
b0005634cellular_componentnucleus
b0016567biological_processprotein ubiquitination
b0031461cellular_componentcullin-RING ubiquitin ligase complex
b0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
b0031625molecular_functionubiquitin protein ligase binding
b0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
b0044877molecular_functionprotein-containing complex binding
b0065003biological_processprotein-containing complex assembly
b0080008cellular_componentCul4-RING E3 ubiquitin ligase complex
b1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
c0000109cellular_componentnucleotide-excision repair complex
c0000781cellular_componentchromosome, telomeric region
c0003677molecular_functionDNA binding
c0003684molecular_functiondamaged DNA binding
c0005515molecular_functionprotein binding
c0005576cellular_componentextracellular region
c0005634cellular_componentnucleus
c0005654cellular_componentnucleoplasm
c0005730cellular_componentnucleolus
c0005737cellular_componentcytoplasm
c0006281biological_processDNA repair
c0006289biological_processnucleotide-excision repair
c0006511biological_processubiquitin-dependent protein catabolic process
c0006974biological_processDNA damage response
c0007056biological_processspindle assembly involved in female meiosis
c0007283biological_processspermatogenesis
c0008283biological_processcell population proliferation
c0010498biological_processproteasomal protein catabolic process
c0010506biological_processregulation of autophagy
c0016567biological_processprotein ubiquitination
c0019076biological_processviral release from host cell
c0030174biological_processregulation of DNA-templated DNA replication initiation
c0030674molecular_functionprotein-macromolecule adaptor activity
c0031297biological_processreplication fork processing
c0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
c0031465cellular_componentCul4B-RING E3 ubiquitin ligase complex
c0032814biological_processregulation of natural killer cell activation
c0032991cellular_componentprotein-containing complex
c0034644biological_processcellular response to UV
c0035861cellular_componentsite of double-strand break
c0040029biological_processepigenetic regulation of gene expression
c0042127biological_processregulation of cell population proliferation
c0042752biological_processregulation of circadian rhythm
c0042981biological_processregulation of apoptotic process
c0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
c0044725biological_processepigenetic programming in the zygotic pronuclei
c0044877molecular_functionprotein-containing complex binding
c0045070biological_processpositive regulation of viral genome replication
c0045722biological_processpositive regulation of gluconeogenesis
c0045732biological_processpositive regulation of protein catabolic process
c0045995biological_processregulation of embryonic development
c0046726biological_processpositive regulation by virus of viral protein levels in host cell
c0051702biological_processbiological process involved in interaction with symbiont
c0060964biological_processregulation of miRNA-mediated gene silencing
c0070062cellular_componentextracellular exosome
c0070914biological_processUV-damage excision repair
c0071987molecular_functionWD40-repeat domain binding
c0080008cellular_componentCul4-RING E3 ubiquitin ligase complex
c0080135biological_processregulation of cellular response to stress
c0097602molecular_functioncullin family protein binding
c0160072molecular_functionubiquitin ligase complex scaffold activity
c1901987biological_processregulation of cell cycle phase transition
c1901990biological_processregulation of mitotic cell cycle phase transition
c1902412biological_processregulation of mitotic cytokinesis
c1904178biological_processnegative regulation of adipose tissue development
c2000036biological_processregulation of stem cell population maintenance
e0005515molecular_functionprotein binding
e0005634cellular_componentnucleus
e0016567biological_processprotein ubiquitination
e0031461cellular_componentcullin-RING ubiquitin ligase complex
e0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
e0031625molecular_functionubiquitin protein ligase binding
e0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
e0044877molecular_functionprotein-containing complex binding
e0065003biological_processprotein-containing complex assembly
e0080008cellular_componentCul4-RING E3 ubiquitin ligase complex
e1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
f0000109cellular_componentnucleotide-excision repair complex
f0000781cellular_componentchromosome, telomeric region
f0003677molecular_functionDNA binding
f0003684molecular_functiondamaged DNA binding
f0005515molecular_functionprotein binding
f0005576cellular_componentextracellular region
f0005634cellular_componentnucleus
f0005654cellular_componentnucleoplasm
f0005730cellular_componentnucleolus
f0005737cellular_componentcytoplasm
f0006281biological_processDNA repair
f0006289biological_processnucleotide-excision repair
f0006511biological_processubiquitin-dependent protein catabolic process
f0006974biological_processDNA damage response
f0007056biological_processspindle assembly involved in female meiosis
f0007283biological_processspermatogenesis
f0008283biological_processcell population proliferation
f0010498biological_processproteasomal protein catabolic process
f0010506biological_processregulation of autophagy
f0016567biological_processprotein ubiquitination
f0019076biological_processviral release from host cell
f0030174biological_processregulation of DNA-templated DNA replication initiation
f0030674molecular_functionprotein-macromolecule adaptor activity
f0031297biological_processreplication fork processing
f0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
f0031465cellular_componentCul4B-RING E3 ubiquitin ligase complex
f0032814biological_processregulation of natural killer cell activation
f0032991cellular_componentprotein-containing complex
f0034644biological_processcellular response to UV
f0035861cellular_componentsite of double-strand break
f0040029biological_processepigenetic regulation of gene expression
f0042127biological_processregulation of cell population proliferation
f0042752biological_processregulation of circadian rhythm
f0042981biological_processregulation of apoptotic process
f0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
f0044725biological_processepigenetic programming in the zygotic pronuclei
f0044877molecular_functionprotein-containing complex binding
f0045070biological_processpositive regulation of viral genome replication
f0045722biological_processpositive regulation of gluconeogenesis
f0045732biological_processpositive regulation of protein catabolic process
f0045995biological_processregulation of embryonic development
f0046726biological_processpositive regulation by virus of viral protein levels in host cell
f0051702biological_processbiological process involved in interaction with symbiont
f0060964biological_processregulation of miRNA-mediated gene silencing
f0070062cellular_componentextracellular exosome
f0070914biological_processUV-damage excision repair
f0071987molecular_functionWD40-repeat domain binding
f0080008cellular_componentCul4-RING E3 ubiquitin ligase complex
f0080135biological_processregulation of cellular response to stress
f0097602molecular_functioncullin family protein binding
f0160072molecular_functionubiquitin ligase complex scaffold activity
f1901987biological_processregulation of cell cycle phase transition
f1901990biological_processregulation of mitotic cell cycle phase transition
f1902412biological_processregulation of mitotic cytokinesis
f1904178biological_processnegative regulation of adipose tissue development
f2000036biological_processregulation of stem cell population maintenance
Functional Information from PROSITE/UniProt
site_idPS00183
Number of Residues16
DetailsUBC_1 Ubiquitin-conjugating (UBC) active site signature. YHCNInsq.GvICLdiL
ChainResidueDetails
aTYR120-LEU135
site_idPS00518
Number of Residues10
DetailsZF_RING_1 Zinc finger RING-type signature. CgHsFCykCI
ChainResidueDetails
HCYS151-ILE160
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. IVSAstDsQLKLWNV
ChainResidueDetails
HILE613-VAL627
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues156
DetailsRepeat: {"description":"WD 1"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues240
DetailsRepeat: {"description":"WD 2"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues320
DetailsRepeat: {"description":"WD 3"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues320
DetailsRepeat: {"description":"WD 4"}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues304
DetailsRepeat: {"description":"WD 5"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues312
DetailsRepeat: {"description":"WD 6"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues16
DetailsRegion: {"description":"Interaction with TRIB1","evidences":[{"source":"PubMed","id":"27041596","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues60
DetailsMotif: {"description":"Nuclear export signal","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues14
DetailsSite: {"description":"Interaction with TRIB1","evidences":[{"source":"PubMed","id":"27041596","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues152
DetailsZinc finger: {"description":"RING-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues272
DetailsCoiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsModified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues292
DetailsDomain: {"description":"UBC core","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsActive site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10133","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues686
DetailsRegion: {"description":"WD repeat beta-propeller A"}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues369
DetailsRegion: {"description":"Interaction with CDT1 and CUL4A","evidences":[{"source":"PubMed","id":"15448697","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues2
DetailsModified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q9ESW0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

253795

PDB entries from 2026-05-20

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