9LTZ

protein structure of DDB1-DDA1-DET1-Ube2e2 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005515	molecular_function	protein binding
A	0006513	biological_process	protein monoubiquitination
A	0006974	biological_process	DNA damage response
A	0016567	biological_process	protein ubiquitination
A	0032020	biological_process	ISG15-protein conjugation
A	0042296	molecular_function	ISG15 transferase activity
A	0061631	molecular_function	ubiquitin conjugating enzyme activity
A	0070534	biological_process	protein K63-linked ubiquitination
A	0070936	biological_process	protein K48-linked ubiquitination
A	0070979	biological_process	protein K11-linked ubiquitination
A	1900087	biological_process	positive regulation of G1/S transition of mitotic cell cycle
F	0000209	biological_process	protein polyubiquitination
F	0005515	molecular_function	protein binding
F	0005654	cellular_component	nucleoplasm
F	0016567	biological_process	protein ubiquitination
F	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
F	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
F	0032814	biological_process	regulation of natural killer cell activation
F	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0016567	biological_process	protein ubiquitination
R	0031461	cellular_component	cullin-RING ubiquitin ligase complex
R	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
R	0031625	molecular_function	ubiquitin protein ligase binding
R	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
R	0044877	molecular_function	protein-containing complex binding
R	0065003	biological_process	protein-containing complex assembly
R	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
R	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
S	0000109	cellular_component	nucleotide-excision repair complex
S	0000781	cellular_component	chromosome, telomeric region
S	0003677	molecular_function	DNA binding
S	0003684	molecular_function	damaged DNA binding
S	0005515	molecular_function	protein binding
S	0005576	cellular_component	extracellular region
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005730	cellular_component	nucleolus
S	0005737	cellular_component	cytoplasm
S	0006281	biological_process	DNA repair
S	0006289	biological_process	nucleotide-excision repair
S	0006511	biological_process	ubiquitin-dependent protein catabolic process
S	0006974	biological_process	DNA damage response
S	0007056	biological_process	spindle assembly involved in female meiosis
S	0007283	biological_process	spermatogenesis
S	0008283	biological_process	cell population proliferation
S	0010498	biological_process	proteasomal protein catabolic process
S	0010506	biological_process	regulation of autophagy
S	0016567	biological_process	protein ubiquitination
S	0019076	biological_process	viral release from host cell
S	0030174	biological_process	regulation of DNA-templated DNA replication initiation
S	0030674	molecular_function	protein-macromolecule adaptor activity
S	0031297	biological_process	replication fork processing
S	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
S	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
S	0032814	biological_process	regulation of natural killer cell activation
S	0032991	cellular_component	protein-containing complex
S	0034644	biological_process	cellular response to UV
S	0035861	cellular_component	site of double-strand break
S	0040029	biological_process	epigenetic regulation of gene expression
S	0042127	biological_process	regulation of cell population proliferation
S	0042752	biological_process	regulation of circadian rhythm
S	0042981	biological_process	regulation of apoptotic process
S	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
S	0044725	biological_process	epigenetic programming in the zygotic pronuclei
S	0044877	molecular_function	protein-containing complex binding
S	0045070	biological_process	positive regulation of viral genome replication
S	0045722	biological_process	positive regulation of gluconeogenesis
S	0045732	biological_process	positive regulation of protein catabolic process
S	0045995	biological_process	regulation of embryonic development
S	0046726	biological_process	positive regulation by virus of viral protein levels in host cell
S	0051702	biological_process	biological process involved in interaction with symbiont
S	0060964	biological_process	regulation of miRNA-mediated gene silencing
S	0070062	cellular_component	extracellular exosome
S	0070914	biological_process	UV-damage excision repair
S	0071987	molecular_function	WD40-repeat domain binding
S	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
S	0080135	biological_process	regulation of cellular response to stress
S	0097602	molecular_function	cullin family protein binding
S	0160072	molecular_function	ubiquitin ligase complex scaffold activity
S	1901987	biological_process	regulation of cell cycle phase transition
S	1901990	biological_process	regulation of mitotic cell cycle phase transition
S	1902412	biological_process	regulation of mitotic cytokinesis
S	1904178	biological_process	negative regulation of adipose tissue development
S	2000036	biological_process	regulation of stem cell population maintenance

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q9ESW0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10133","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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