9LTR

Cryo-EM structure of dimeric DDB1-DDA1-DET1-Ube2e2-COP1 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005515	molecular_function	protein binding
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0010212	biological_process	response to ionizing radiation
A	0016567	biological_process	protein ubiquitination
A	0016607	cellular_component	nuclear speck
A	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
A	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0045717	biological_process	negative regulation of fatty acid biosynthetic process
A	0061630	molecular_function	ubiquitin protein ligase activity
B	0000109	cellular_component	nucleotide-excision repair complex
B	0000781	cellular_component	chromosome, telomeric region
B	0003677	molecular_function	DNA binding
B	0003684	molecular_function	damaged DNA binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0006281	biological_process	DNA repair
B	0006289	biological_process	nucleotide-excision repair
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0006974	biological_process	DNA damage response
B	0007056	biological_process	spindle assembly involved in female meiosis
B	0007283	biological_process	spermatogenesis
B	0008283	biological_process	cell population proliferation
B	0010498	biological_process	proteasomal protein catabolic process
B	0010506	biological_process	regulation of autophagy
B	0016567	biological_process	protein ubiquitination
B	0019076	biological_process	viral release from host cell
B	0030174	biological_process	regulation of DNA-templated DNA replication initiation
B	0030674	molecular_function	protein-macromolecule adaptor activity
B	0031297	biological_process	replication fork processing
B	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
B	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
B	0032814	biological_process	regulation of natural killer cell activation
B	0032991	cellular_component	protein-containing complex
B	0034644	biological_process	cellular response to UV
B	0035861	cellular_component	site of double-strand break
B	0040029	biological_process	epigenetic regulation of gene expression
B	0042127	biological_process	regulation of cell population proliferation
B	0042752	biological_process	regulation of circadian rhythm
B	0042981	biological_process	regulation of apoptotic process
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0044725	biological_process	epigenetic programming in the zygotic pronuclei
B	0044877	molecular_function	protein-containing complex binding
B	0045070	biological_process	positive regulation of viral genome replication
B	0045722	biological_process	positive regulation of gluconeogenesis
B	0045732	biological_process	positive regulation of protein catabolic process
B	0045995	biological_process	regulation of embryonic development
B	0046726	biological_process	positive regulation by virus of viral protein levels in host cell
B	0051702	biological_process	biological process involved in interaction with symbiont
B	0060964	biological_process	regulation of miRNA-mediated gene silencing
B	0070062	cellular_component	extracellular exosome
B	0070914	biological_process	UV-damage excision repair
B	0071987	molecular_function	WD40-repeat domain binding
B	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
B	0080135	biological_process	regulation of cellular response to stress
B	0097602	molecular_function	cullin family protein binding
B	0160072	molecular_function	ubiquitin ligase complex scaffold activity
B	1901987	biological_process	regulation of cell cycle phase transition
B	1901990	biological_process	regulation of mitotic cell cycle phase transition
B	1902412	biological_process	regulation of mitotic cytokinesis
B	1904178	biological_process	negative regulation of adipose tissue development
B	2000036	biological_process	regulation of stem cell population maintenance
C	0000139	cellular_component	Golgi membrane
C	0004842	molecular_function	ubiquitin-protein transferase activity
C	0005515	molecular_function	protein binding
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0010212	biological_process	response to ionizing radiation
C	0016567	biological_process	protein ubiquitination
C	0016607	cellular_component	nuclear speck
C	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
C	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0045717	biological_process	negative regulation of fatty acid biosynthetic process
C	0061630	molecular_function	ubiquitin protein ligase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0016567	biological_process	protein ubiquitination
D	0031461	cellular_component	cullin-RING ubiquitin ligase complex
D	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
D	0044877	molecular_function	protein-containing complex binding
D	0065003	biological_process	protein-containing complex assembly
D	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
D	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
E	0000109	cellular_component	nucleotide-excision repair complex
E	0000781	cellular_component	chromosome, telomeric region
E	0003677	molecular_function	DNA binding
E	0003684	molecular_function	damaged DNA binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005730	cellular_component	nucleolus
E	0005737	cellular_component	cytoplasm
E	0006281	biological_process	DNA repair
E	0006289	biological_process	nucleotide-excision repair
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0006974	biological_process	DNA damage response
E	0007056	biological_process	spindle assembly involved in female meiosis
E	0007283	biological_process	spermatogenesis
E	0008283	biological_process	cell population proliferation
E	0010498	biological_process	proteasomal protein catabolic process
E	0010506	biological_process	regulation of autophagy
E	0016567	biological_process	protein ubiquitination
E	0019076	biological_process	viral release from host cell
E	0030174	biological_process	regulation of DNA-templated DNA replication initiation
E	0030674	molecular_function	protein-macromolecule adaptor activity
E	0031297	biological_process	replication fork processing
E	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
E	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
E	0032814	biological_process	regulation of natural killer cell activation
E	0032991	cellular_component	protein-containing complex
E	0034644	biological_process	cellular response to UV
E	0035861	cellular_component	site of double-strand break
E	0040029	biological_process	epigenetic regulation of gene expression
E	0042127	biological_process	regulation of cell population proliferation
E	0042752	biological_process	regulation of circadian rhythm
E	0042981	biological_process	regulation of apoptotic process
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0044725	biological_process	epigenetic programming in the zygotic pronuclei
E	0044877	molecular_function	protein-containing complex binding
E	0045070	biological_process	positive regulation of viral genome replication
E	0045722	biological_process	positive regulation of gluconeogenesis
E	0045732	biological_process	positive regulation of protein catabolic process
E	0045995	biological_process	regulation of embryonic development
E	0046726	biological_process	positive regulation by virus of viral protein levels in host cell
E	0051702	biological_process	biological process involved in interaction with symbiont
E	0060964	biological_process	regulation of miRNA-mediated gene silencing
E	0070062	cellular_component	extracellular exosome
E	0070914	biological_process	UV-damage excision repair
E	0071987	molecular_function	WD40-repeat domain binding
E	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
E	0080135	biological_process	regulation of cellular response to stress
E	0097602	molecular_function	cullin family protein binding
E	0160072	molecular_function	ubiquitin ligase complex scaffold activity
E	1901987	biological_process	regulation of cell cycle phase transition
E	1901990	biological_process	regulation of mitotic cell cycle phase transition
E	1902412	biological_process	regulation of mitotic cytokinesis
E	1904178	biological_process	negative regulation of adipose tissue development
E	2000036	biological_process	regulation of stem cell population maintenance
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0016567	biological_process	protein ubiquitination
H	0031461	cellular_component	cullin-RING ubiquitin ligase complex
H	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
H	0031625	molecular_function	ubiquitin protein ligase binding
H	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
H	0044877	molecular_function	protein-containing complex binding
H	0065003	biological_process	protein-containing complex assembly
H	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
H	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
I	0000209	biological_process	protein polyubiquitination
I	0005515	molecular_function	protein binding
I	0005654	cellular_component	nucleoplasm
I	0016567	biological_process	protein ubiquitination
I	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
I	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
I	0032814	biological_process	regulation of natural killer cell activation
I	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
J	0004842	molecular_function	ubiquitin-protein transferase activity
J	0005515	molecular_function	protein binding
J	0006513	biological_process	protein monoubiquitination
J	0006974	biological_process	DNA damage response
J	0016567	biological_process	protein ubiquitination
J	0032020	biological_process	ISG15-protein conjugation
J	0042296	molecular_function	ISG15 transferase activity
J	0061631	molecular_function	ubiquitin conjugating enzyme activity
J	0070534	biological_process	protein K63-linked ubiquitination
J	0070936	biological_process	protein K48-linked ubiquitination
J	0070979	biological_process	protein K11-linked ubiquitination
J	1900087	biological_process	positive regulation of G1/S transition of mitotic cell cycle
K	0004842	molecular_function	ubiquitin-protein transferase activity
K	0005515	molecular_function	protein binding
K	0006513	biological_process	protein monoubiquitination
K	0006974	biological_process	DNA damage response
K	0016567	biological_process	protein ubiquitination
K	0032020	biological_process	ISG15-protein conjugation
K	0042296	molecular_function	ISG15 transferase activity
K	0061631	molecular_function	ubiquitin conjugating enzyme activity
K	0070534	biological_process	protein K63-linked ubiquitination
K	0070936	biological_process	protein K48-linked ubiquitination
K	0070979	biological_process	protein K11-linked ubiquitination
K	1900087	biological_process	positive regulation of G1/S transition of mitotic cell cycle
P	0000209	biological_process	protein polyubiquitination
P	0005515	molecular_function	protein binding
P	0005654	cellular_component	nucleoplasm
P	0016567	biological_process	protein ubiquitination
P	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
P	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
P	0032814	biological_process	regulation of natural killer cell activation
P	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex

Functional Information from PROSITE/UniProt

site_id	PS00183
Number of Residues	16
Details	UBC_1 Ubiquitin-conjugating (UBC) active site signature. YHCNInsq.GvICLdiL

Chain	Residue	Details
J	TYR128-LEU143

---

site_id	PS00518
Number of Residues	10
Details	ZF_RING_1 Zinc finger RING-type signature. CgHsFCykCI

Chain	Residue	Details
A	CYS151-ILE160

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. IVSAstDsQLKLWNV

Chain	Residue	Details
A	ILE613-VAL627

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	78
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	80
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	80
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	78
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Region: {"description":"Interaction with TRIB1","evidences":[{"source":"PubMed","id":"27041596","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Site: {"description":"Interaction with TRIB1","evidences":[{"source":"PubMed","id":"27041596","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	40
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	686
Details	Region: {"description":"WD repeat beta-propeller A"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q9ESW0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	292
Details	Domain: {"description":"UBC core","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10133","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---