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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9LRN

The crystal structure of PDE2A with 13t

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000287molecular_functionmagnesium ion binding
A0003170biological_processheart valve development
A0003281biological_processventricular septum development
A0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
A0004115molecular_function3',5'-cyclic-AMP phosphodiesterase activity
A0004118molecular_function3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005741cellular_componentmitochondrial outer membrane
A0005743cellular_componentmitochondrial inner membrane
A0005759cellular_componentmitochondrial matrix
A0005783cellular_componentendoplasmic reticulum
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
A0008270molecular_functionzinc ion binding
A0009154biological_processpurine ribonucleotide catabolic process
A0009214biological_processcyclic nucleotide catabolic process
A0010628biological_processpositive regulation of gene expression
A0010754biological_processnegative regulation of receptor guanylyl cyclase signaling pathway
A0010821biological_processregulation of mitochondrion organization
A0030552molecular_functioncAMP binding
A0030553molecular_functioncGMP binding
A0030911molecular_functionTPR domain binding
A0035904biological_processaorta development
A0036006biological_processcellular response to macrophage colony-stimulating factor stimulus
A0042301molecular_functionphosphate ion binding
A0042734cellular_componentpresynaptic membrane
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043116biological_processnegative regulation of vascular permeability
A0043117biological_processpositive regulation of vascular permeability
A0046069biological_processcGMP catabolic process
A0047555molecular_function3',5'-cyclic-GMP phosphodiesterase activity
A0048471cellular_componentperinuclear region of cytoplasm
A0050729biological_processpositive regulation of inflammatory response
A0052652biological_processcyclic purine nucleotide metabolic process
A0061028biological_processestablishment of endothelial barrier
A0071260biological_processcellular response to mechanical stimulus
A0071320biological_processcellular response to cAMP
A0071321biological_processcellular response to cGMP
A0071560biological_processcellular response to transforming growth factor beta stimulus
A0097060cellular_componentsynaptic membrane
A0106072biological_processnegative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
A0141162biological_processnegative regulation of cAMP/PKA signal transduction
A1904613biological_processcellular response to 2,3,7,8-tetrachlorodibenzodioxine
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000287molecular_functionmagnesium ion binding
B0003170biological_processheart valve development
B0003281biological_processventricular septum development
B0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
B0004115molecular_function3',5'-cyclic-AMP phosphodiesterase activity
B0004118molecular_function3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005741cellular_componentmitochondrial outer membrane
B0005743cellular_componentmitochondrial inner membrane
B0005759cellular_componentmitochondrial matrix
B0005783cellular_componentendoplasmic reticulum
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
B0008270molecular_functionzinc ion binding
B0009154biological_processpurine ribonucleotide catabolic process
B0009214biological_processcyclic nucleotide catabolic process
B0010628biological_processpositive regulation of gene expression
B0010754biological_processnegative regulation of receptor guanylyl cyclase signaling pathway
B0010821biological_processregulation of mitochondrion organization
B0030552molecular_functioncAMP binding
B0030553molecular_functioncGMP binding
B0030911molecular_functionTPR domain binding
B0035904biological_processaorta development
B0036006biological_processcellular response to macrophage colony-stimulating factor stimulus
B0042301molecular_functionphosphate ion binding
B0042734cellular_componentpresynaptic membrane
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043116biological_processnegative regulation of vascular permeability
B0043117biological_processpositive regulation of vascular permeability
B0046069biological_processcGMP catabolic process
B0047555molecular_function3',5'-cyclic-GMP phosphodiesterase activity
B0048471cellular_componentperinuclear region of cytoplasm
B0050729biological_processpositive regulation of inflammatory response
B0052652biological_processcyclic purine nucleotide metabolic process
B0061028biological_processestablishment of endothelial barrier
B0071260biological_processcellular response to mechanical stimulus
B0071320biological_processcellular response to cAMP
B0071321biological_processcellular response to cGMP
B0071560biological_processcellular response to transforming growth factor beta stimulus
B0097060cellular_componentsynaptic membrane
B0106072biological_processnegative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
B0141162biological_processnegative regulation of cAMP/PKA signal transduction
B1904613biological_processcellular response to 2,3,7,8-tetrachlorodibenzodioxine
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000287molecular_functionmagnesium ion binding
C0003170biological_processheart valve development
C0003281biological_processventricular septum development
C0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
C0004115molecular_function3',5'-cyclic-AMP phosphodiesterase activity
C0004118molecular_function3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005741cellular_componentmitochondrial outer membrane
C0005743cellular_componentmitochondrial inner membrane
C0005759cellular_componentmitochondrial matrix
C0005783cellular_componentendoplasmic reticulum
C0005794cellular_componentGolgi apparatus
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
C0008270molecular_functionzinc ion binding
C0009154biological_processpurine ribonucleotide catabolic process
C0009214biological_processcyclic nucleotide catabolic process
C0010628biological_processpositive regulation of gene expression
C0010754biological_processnegative regulation of receptor guanylyl cyclase signaling pathway
C0010821biological_processregulation of mitochondrion organization
C0030552molecular_functioncAMP binding
C0030553molecular_functioncGMP binding
C0030911molecular_functionTPR domain binding
C0035904biological_processaorta development
C0036006biological_processcellular response to macrophage colony-stimulating factor stimulus
C0042301molecular_functionphosphate ion binding
C0042734cellular_componentpresynaptic membrane
C0042802molecular_functionidentical protein binding
C0042803molecular_functionprotein homodimerization activity
C0043116biological_processnegative regulation of vascular permeability
C0043117biological_processpositive regulation of vascular permeability
C0046069biological_processcGMP catabolic process
C0047555molecular_function3',5'-cyclic-GMP phosphodiesterase activity
C0048471cellular_componentperinuclear region of cytoplasm
C0050729biological_processpositive regulation of inflammatory response
C0052652biological_processcyclic purine nucleotide metabolic process
C0061028biological_processestablishment of endothelial barrier
C0071260biological_processcellular response to mechanical stimulus
C0071320biological_processcellular response to cAMP
C0071321biological_processcellular response to cGMP
C0071560biological_processcellular response to transforming growth factor beta stimulus
C0097060cellular_componentsynaptic membrane
C0106072biological_processnegative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
C0141162biological_processnegative regulation of cAMP/PKA signal transduction
C1904613biological_processcellular response to 2,3,7,8-tetrachlorodibenzodioxine
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0000287molecular_functionmagnesium ion binding
D0003170biological_processheart valve development
D0003281biological_processventricular septum development
D0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
D0004115molecular_function3',5'-cyclic-AMP phosphodiesterase activity
D0004118molecular_function3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005741cellular_componentmitochondrial outer membrane
D0005743cellular_componentmitochondrial inner membrane
D0005759cellular_componentmitochondrial matrix
D0005783cellular_componentendoplasmic reticulum
D0005794cellular_componentGolgi apparatus
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
D0008270molecular_functionzinc ion binding
D0009154biological_processpurine ribonucleotide catabolic process
D0009214biological_processcyclic nucleotide catabolic process
D0010628biological_processpositive regulation of gene expression
D0010754biological_processnegative regulation of receptor guanylyl cyclase signaling pathway
D0010821biological_processregulation of mitochondrion organization
D0030552molecular_functioncAMP binding
D0030553molecular_functioncGMP binding
D0030911molecular_functionTPR domain binding
D0035904biological_processaorta development
D0036006biological_processcellular response to macrophage colony-stimulating factor stimulus
D0042301molecular_functionphosphate ion binding
D0042734cellular_componentpresynaptic membrane
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0043116biological_processnegative regulation of vascular permeability
D0043117biological_processpositive regulation of vascular permeability
D0046069biological_processcGMP catabolic process
D0047555molecular_function3',5'-cyclic-GMP phosphodiesterase activity
D0048471cellular_componentperinuclear region of cytoplasm
D0050729biological_processpositive regulation of inflammatory response
D0052652biological_processcyclic purine nucleotide metabolic process
D0061028biological_processestablishment of endothelial barrier
D0071260biological_processcellular response to mechanical stimulus
D0071320biological_processcellular response to cAMP
D0071321biological_processcellular response to cGMP
D0071560biological_processcellular response to transforming growth factor beta stimulus
D0097060cellular_componentsynaptic membrane
D0106072biological_processnegative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
D0141162biological_processnegative regulation of cAMP/PKA signal transduction
D1904613biological_processcellular response to 2,3,7,8-tetrachlorodibenzodioxine
Functional Information from PROSITE/UniProt
site_idPS00126
Number of Residues12
DetailsPDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGtnNsF
ChainResidueDetails
AHIS696-PHE707
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsActive site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"O76083","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"15938621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19828435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23899287","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Z1L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ITM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ITU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HTX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JIB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"15938621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19828435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23899287","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Z1L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ITM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ITU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HTX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JIB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

258009

PDB entries from 2026-08-12

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