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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9LQZ

Cryo-EM structure of the AMG986-bound state 2b of APLNR homodimer

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0001568biological_processblood vessel development
A0001570biological_processvasculogenesis
A0001944biological_processvasculature development
A0001947biological_processheart looping
A0003171biological_processatrioventricular valve development
A0003272biological_processendocardial cushion formation
A0004930molecular_functionG protein-coupled receptor activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0007186biological_processG protein-coupled receptor signaling pathway
A0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
A0007507biological_processheart development
A0007512biological_processadult heart development
A0008528molecular_functionG protein-coupled peptide receptor activity
A0010468biological_processregulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0035886biological_processvascular associated smooth muscle cell differentiation
A0035904biological_processaorta development
A0038023molecular_functionsignaling receptor activity
A0045766biological_processpositive regulation of angiogenesis
A0050878biological_processregulation of body fluid levels
A0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
A0060182molecular_functionapelin receptor activity
A0060183biological_processapelin receptor signaling pathway
A0060412biological_processventricular septum morphogenesis
A0060841biological_processvenous blood vessel development
A0060976biological_processcoronary vasculature development
A0140897molecular_functionmechanoreceptor activity
A1903243biological_processnegative regulation of cardiac muscle hypertrophy in response to stress
A1903244biological_processpositive regulation of cardiac muscle hypertrophy in response to stress
A1903589biological_processpositive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
A1903596biological_processregulation of gap junction assembly
A1904022biological_processpositive regulation of G protein-coupled receptor internalization
B0001568biological_processblood vessel development
B0001570biological_processvasculogenesis
B0001944biological_processvasculature development
B0001947biological_processheart looping
B0003171biological_processatrioventricular valve development
B0003272biological_processendocardial cushion formation
B0004930molecular_functionG protein-coupled receptor activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0007186biological_processG protein-coupled receptor signaling pathway
B0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
B0007507biological_processheart development
B0007512biological_processadult heart development
B0008528molecular_functionG protein-coupled peptide receptor activity
B0010468biological_processregulation of gene expression
B0010629biological_processnegative regulation of gene expression
B0035886biological_processvascular associated smooth muscle cell differentiation
B0035904biological_processaorta development
B0038023molecular_functionsignaling receptor activity
B0045766biological_processpositive regulation of angiogenesis
B0050878biological_processregulation of body fluid levels
B0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
B0060182molecular_functionapelin receptor activity
B0060183biological_processapelin receptor signaling pathway
B0060412biological_processventricular septum morphogenesis
B0060841biological_processvenous blood vessel development
B0060976biological_processcoronary vasculature development
B0140897molecular_functionmechanoreceptor activity
B1903243biological_processnegative regulation of cardiac muscle hypertrophy in response to stress
B1903244biological_processpositive regulation of cardiac muscle hypertrophy in response to stress
B1903589biological_processpositive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
B1903596biological_processregulation of gap junction assembly
B1904022biological_processpositive regulation of G protein-coupled receptor internalization
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASVfCLTGLSFDRYLaI
ChainResidueDetails
AALA115-ILE131
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues46
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"35817871","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W0O","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues60
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues42
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"35817871","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W0O","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues126
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues50
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"35817871","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W0O","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues34
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"35817871","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W0O","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues48
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"35817871","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W0O","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues46
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"35817871","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W0O","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues44
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"35817871","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W0O","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues4
DetailsSite: {"description":"Required for APELA and APLN/apelin-13 interaction and signaling","evidences":[{"source":"PubMed","id":"35817871","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38428423","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

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PDB entries from 2026-04-01

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