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9LQ2

Structure of human dimeric NLRP7-TCL1A complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0005737cellular_componentcytoplasm
A0005938cellular_componentcell cortex
A0010955biological_processnegative regulation of protein processing
A0019828molecular_functionaspartic-type endopeptidase inhibitor activity
A0019966molecular_functioninterleukin-1 binding
A0032691biological_processnegative regulation of interleukin-1 beta production
A0040019biological_processpositive regulation of embryonic development
A0050727biological_processregulation of inflammatory response
A0051293biological_processestablishment of spindle localization
A0071222biological_processcellular response to lipopolysaccharide
A0071347biological_processcellular response to interleukin-1
A0089720molecular_functioncaspase binding
A0106333cellular_componentsubcortical maternal complex
A1900016biological_processnegative regulation of cytokine production involved in inflammatory response
B0005737cellular_componentcytoplasm
B0005938cellular_componentcell cortex
B0010955biological_processnegative regulation of protein processing
B0019828molecular_functionaspartic-type endopeptidase inhibitor activity
B0019966molecular_functioninterleukin-1 binding
B0032691biological_processnegative regulation of interleukin-1 beta production
B0040019biological_processpositive regulation of embryonic development
B0050727biological_processregulation of inflammatory response
B0051293biological_processestablishment of spindle localization
B0071222biological_processcellular response to lipopolysaccharide
B0071347biological_processcellular response to interleukin-1
B0089720molecular_functioncaspase binding
B0106333cellular_componentsubcortical maternal complex
B1900016biological_processnegative regulation of cytokine production involved in inflammatory response
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005783cellular_componentendoplasmic reticulum
D0005829cellular_componentcytosol
D0019901molecular_functionprotein kinase binding
D0035556biological_processintracellular signal transduction
D0042802molecular_functionidentical protein binding
D0043539molecular_functionprotein serine/threonine kinase activator activity
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005737cellular_componentcytoplasm
E0005783cellular_componentendoplasmic reticulum
E0005829cellular_componentcytosol
E0019901molecular_functionprotein kinase binding
E0035556biological_processintracellular signal transduction
E0042802molecular_functionidentical protein binding
E0043539molecular_functionprotein serine/threonine kinase activator activity
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005783cellular_componentendoplasmic reticulum
F0005829cellular_componentcytosol
F0019901molecular_functionprotein kinase binding
F0035556biological_processintracellular signal transduction
F0042802molecular_functionidentical protein binding
F0043539molecular_functionprotein serine/threonine kinase activator activity
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005737cellular_componentcytoplasm
G0005783cellular_componentendoplasmic reticulum
G0005829cellular_componentcytosol
G0019901molecular_functionprotein kinase binding
G0035556biological_processintracellular signal transduction
G0042802molecular_functionidentical protein binding
G0043539molecular_functionprotein serine/threonine kinase activator activity
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues46
DetailsRepeat: {"description":"LRR 2"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues48
DetailsRepeat: {"description":"LRR 3"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues44
DetailsRepeat: {"description":"LRR 4"}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues23
DetailsRepeat: {"description":"LRR 5"}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues23
DetailsRepeat: {"description":"LRR 6"}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues23
DetailsRepeat: {"description":"LRR 7"}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues26
DetailsRepeat: {"description":"LRR 8"}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues14
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00136","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

254587

PDB entries from 2026-06-03

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